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公开(公告)号：US11633358B2
公开(公告)日：2023-04-25
申请号：US17190537
申请日：2021-03-03
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Ronit Goldberg , Jasmine Seror , Weifeng Lin , Reut Mashiach
IPC: A61K9/127 , A61K9/00 , A61K47/32 , A61K47/10 , A61K47/36 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , B65D35/00 , B65D75/36
Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
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公开(公告)号：US10940111B2
公开(公告)日：2021-03-09
申请号：US15319005
申请日：2015-06-15
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Ronit Goldberg , Jasmine Seror , Weifeng Lin , Reut Mashiach
IPC: A61K9/127 , A61K9/00 , A61K47/32 , A61K47/10 , A61K47/36 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , B65D35/00 , B65D75/36
Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
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公开(公告)号：US11883533B2
公开(公告)日：2024-01-30
申请号：US15319014
申请日：2015-06-15
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Ronit Goldberg , Jasmine Seror
IPC: A61K9/127 , A61K9/00 , A61K47/32 , A61K47/10 , A61K47/36 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , B65D35/00 , B65D75/36
CPC classification number: A61K9/127 , A61K9/0048 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , A61K47/10 , A61K47/32 , A61K47/36 , B65D35/00 , B65D75/36
Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
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公开(公告)号：US10799619B2
公开(公告)日：2020-10-13
申请号：US16387591
申请日：2019-04-18
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Ronit Goldberg , Noa Iuster , Raya Sorkin
Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
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公开(公告)号：US12116428B2
公开(公告)日：2024-10-15
申请号：US17872050
申请日：2022-07-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Weifeng Lin , Ronit Goldberg
CPC classification number: C08F130/02 , A61K9/0051 , A61K9/08 , A61K9/1273 , A61P19/02 , C07F9/106 , A61K9/0019 , A61K47/6909 , C08F2438/01
Abstract: A polymeric compound is disclosed herein, having the general formula I:
wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.-
Patent Agency Ranking
公开(公告)号：US11684578B2
公开(公告)日：2023-06-27
申请号：US16485855
申请日：2018-02-16
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Ronit Goldberg , Weifeng Lin
CPC classification number: A61K9/1273 , A61K9/0019 , A61P19/02
Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises:
a) at least one bilayer-forming lipid;
b) a polymeric compound having the general formula I:
wherein m, n, L, X, Y, and Z are as defined herein; and
c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.-
公开(公告)号：US11541008B2
公开(公告)日：2023-01-03
申请号：US16809816
申请日：2020-03-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
Inventor： Jacob Klein , Ronit Goldberg , Yechezkel Barenholtz , Avi Schroeder
Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
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公开(公告)号：US20200338001A1
公开(公告)日：2020-10-29
申请号：US16809816
申请日：2020-03-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
Inventor： Jacob Klein , Ronit Goldberg , Yechezkel Barenholtz , Avi Schroeder
Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
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公开(公告)号：US10730976B2
公开(公告)日：2020-08-04
申请号：US16064498
申请日：2016-12-22
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Weifeng Lin , Ronit Goldberg
Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
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公开(公告)号：US10314946B2
公开(公告)日：2019-06-11
申请号：US15890504
申请日：2018-02-07
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Ronit Goldberg , Noa Iuster , Raya Sorkin
Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
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