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    METHOD AND APPARATUS FOR SELECTING PHARMACOGENOMIC MARKERS
    4.
    发明申请
    METHOD AND APPARATUS FOR SELECTING PHARMACOGENOMIC MARKERS 审中-公开
    选择药物生物学标记的方法和装置

    公开(公告)号：US20100204922A1

    公开(公告)日：2010-08-12

    申请号：US12623675

    申请日：2009-11-23

    申请人： Tae-jin AHN ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK

    发明人： Tae-jin AHN ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK

    IPC分类号： G06F19/00 ,  G06F17/18

    CPC分类号： G16B20/00

    摘要： Provided are a method and apparatus for selecting pharmacogenomic markers. The method includes calculating evaluation indexes for evaluating the degree of association between genetic markers of genes associated with at least one drug and the drug, and selecting some of the genetic markers based on the calculated evaluation indexes.

    摘要翻译： 提供了用于选择药物基因组标记物的方法和装置。 该方法包括计算评估指标，以评估与至少一种药物和药物相关的基因的遗传标记之间的关联程度，以及基于所计算的评价指标来选择一些遗传标记。

    METHOD AND APPARATUS FOR DETECTING POSITION OF DATA SPOT ON MICROARRAY
    6.
    发明申请
    METHOD AND APPARATUS FOR DETECTING POSITION OF DATA SPOT ON MICROARRAY 审中-公开
    用于检测微阵列数据点位置的方法和装置

    公开(公告)号：US20100256002A1

    公开(公告)日：2010-10-07

    申请号：US12688938

    申请日：2010-01-18

    申请人： Dae-soon SON ,  Kyu-sang LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-suk CHUNG

    发明人： Dae-soon SON ,  Kyu-sang LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-suk CHUNG

    IPC分类号： C40B30/00 ,  C40B60/12

    CPC分类号： G06K9/0014 ,  G06T7/73 ,  G06T2207/30072

    摘要： In a method and apparatus for detecting positions of data spots on a microarray, images of the microarray are synthesized with a grid-pattern image to distinguish spots on the microarray and synthesized images are thereby generated, and a synthesized image is selected from the synthesized images based on statistics corresponding to light intensities of fiducial spots included in the synthesized images. Accordingly, the positions of the data spots are accurately detected from the selected synthesized image, and the data of the microarray is thereby analyzed.

    摘要翻译： 在用于检测微阵列上的数据点的位置的方法和装置中，利用网格图案合成微阵列的图像，以区分微阵列上的斑点，由此产生合成图像，并从合成图像中选择合成图像 基于对应于合成图像中包含的基准点的光强度的统计量。 因此，从所选择的合成图像中准确地检测数据点的位置，从而分析微阵列的数据。

    METHOD OF DESIGNING PROBES FOR DETECTING TARGET SEQUENCE AND METHOD OF DETECTING TARGET SEQUENCE USING THE PROBES
    8.
    发明申请
    METHOD OF DESIGNING PROBES FOR DETECTING TARGET SEQUENCE AND METHOD OF DETECTING TARGET SEQUENCE USING THE PROBES 有权
    设计用于检测目标序列的探针的方法和使用探测器检测目标序列的方法

    公开(公告)号：US20080139398A1

    公开(公告)日：2008-06-12

    申请号：US11739354

    申请日：2007-04-24

    申请人： Tae-jin AHN ,  Ji-young OH ,  Jung-nam LEE ,  Jong-suk CHUNG

    发明人： Tae-jin AHN ,  Ji-young OH ,  Jung-nam LEE ,  Jong-suk CHUNG

    IPC分类号： C40B30/04 ,  G01N33/50 ,  C07H21/04

    CPC分类号： C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/689 ,  Y10T436/145555 ,  C12Q2521/501 ,  C12Q2525/161 ,  C12Q2525/185

    摘要： A method of designing probes for detecting a target sequence and a method of detecting target sequence using the probes are provided. The method of designing probes for detecting target sequence includes: selecting an anchoring location in the target sequence, wherein the anchoring location is a location in the target sequence at which a first non-target sequence in a plurality of non-target sequences is different from the target sequence, wherein the first non-target sequence has a sequence similarity to the target sequence that is identical to or higher than the sequence similarity of other non-target sequences in the plurality of non-target sequences; selecting a first probe designing region, wherein the first probe designing region is a fixed region in the target sequence comprising the anchoring location; selecting a probe selection location, wherein the probe selection location is a location in the target sequence at which a second non-target sequence in the plurality of non-target sequences is different from the target sequence; selecting a matched probe, wherein the matched probe comprises a sequence complementary to the target sequence, wherein the probe selecting location is at the center of the sequence of the matched probe; and selecting a mismatched probe, wherein the mismatched probe is longer than the matched probe, wherein the mismatched probe comprises a sequence complementary to the target sequence at all locations except at a mismatched location, wherein the probe selection location is at a first location in the sequence of the mismatched probe and the mismatched location is at a second location in the sequence of the mismatched probe.

    摘要翻译： 提供了一种设计用于检测靶序列的探针的方法和使用探针检测靶序列的方法。 设计用于检测目标序列的探针的方法包括：在目标序列中选择锚定位置，其中锚定位置是目标序列中多个非靶序列中的第一非靶序列不同于 所述靶序列，其中所述第一非靶序列与所述靶序列具有与所述多个非靶序列中的其他非靶序列的序列相似性相同或更高的序列相似性; 选择第一探针设计区域，其中所述第一探针设计区域是包括所述锚定位置的所述目标序列中的固定区域; 选择探针选择位置，其中所述探针选择位置是所述多个非靶序列中的第二非靶序列与所述靶序列不同的所述靶序列中的位置; 选择匹配的探针，其中所述匹配的探针包含与所述靶序列互补的序列，其中所述探针选择位置位于所述匹配探针的序列的中心; 以及选择不匹配的探针，其中所述不匹配的探针长于所述匹配的探针，其中所述不匹配的探针包括除所述不匹配位置之外的所有位置处与所述靶序列互补的序列，其中所述探针选择位置位于所述匹配探针的第一位置 不匹配探针和不匹配位置的序列位于错配探针序列中的第二个位置。