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公开(公告)号：US20250136959A1
公开(公告)日：2025-05-01
申请号：US18681789
申请日：2022-08-08
Inventor： Menghao CAI , Qi LIU , Yuanxing ZHANG
Abstract: A transcription regulation system based on CRISPRi and CRISPRa, and an establishment method therefor and the use thereof. The system is a new transcription regulation system which has high expression intensity, a low leakage level and is flexible and programmable. Provided is a method for achieving high-intensity and low-leakage expression of a gene by means of the transcription regulation system, wherein a high-intensity transcription level is achieved while suppressing background expression by means of synergistic regulation on downstream signaling effect devices by means of CRISPRi and CRISPRa dev ices. The new transcription regulation system can obtain, by means of loading different input promoters, a new expression system for responding to a specific signal, and has application value in the development and establishment of an efficient heterologous protein expression platform and a microbial cell factory.
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2.发明申请公开(公告)号：US20250101627A1
公开(公告)日：2025-03-27
申请号：US18832129
申请日：2022-11-11
Inventor： Xue QU , Miao LEI , Changsheng LIU
Abstract: A preparation method of a collagen material stripped from an electrode and a use of the collagen material are provided. The preparation method of a collagen material stripped from an electrode includes the following step: subjecting a collagen solution including hydrogen peroxide and/or acetic acid to electro-deposition (EDP) to obtain the collagen material on the electrode. The preparation method can lead to a collagen material directly on a surface of an electrode.
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公开(公告)号：US20250086340A1
公开(公告)日：2025-03-13
申请号：US18705684
申请日：2021-12-13
Inventor： Fuzhen XUAN , Jianguo GONG , Yang GAO , Mingliang ZHU , Yanxun XIANG
Abstract: A digital twin-based pressure vessel safety evaluation and risk warning method includes steps: S1, determine a damage mode of pressure vessel; S2, design an overall plan of pressure vessel safety evaluation and risk warning; S3, simplify physical model of the pressure vessel and build a simplified physical model based on designed overall plan; S4, obtain load condition parameters during actual service of the pressure vessel; S5, determine material performance parameters of the pressure vessel; S6, build a digital twin model of pressure vessel safety evaluation and risk warning; S7, obtain a full-field damage distribution cloud map of the pressure vessel; S8, compare the full-field damage distribution cloud map and strength requirement of material of pressure vessel, if the strength requirement is met, conduct a safety evaluation at next time node according to subsequent needs of user, and if the strength requirement is not met, output a pressure vessel risk warning.
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公开(公告)号：US20250026976A1
公开(公告)日：2025-01-23
申请号：US18713690
申请日：2023-06-07
Inventor： Bozhong MU , Lei ZHOU , Yifan LIU , Shizhong YANG , Jun WU
Abstract: The present invention relates to a method for inhibiting biogenic hydrogen sulfide in oilfields. A synergistic inhibition system combination agent containing Geobacillus strain GW1 is added into oilfield systems, wherein the strain GW1 has been deposited in China General Microbiological Culture Collection Center on Oct. 20, 2021, and has the deposit number of CGMCC No. 23631.
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公开(公告)号：US12158457B2
公开(公告)日：2024-12-03
申请号：US17794767
申请日：2020-07-18
Inventor： Zejian Wang , Daqi Gao , Xiaoqin Zhang , Bo Li , Fang Cai , Jianhua Li , Mingjian Cheng
Abstract: A method for online detecting and analyzing multiple state parameters in fermentation and malodorous pollution processes by using an electronic nose instrument of gas sensitivity and gas chromatography, where the electronic nose instrument includes a gas sensor array module, a capillary gas chromatographic column module, a gas auto-sampling module, a computer control and analysis module and an auxiliary gas source, which is configured to perform cyclically long-term online detection and intelligent analysis of a plurality of bio-fermentation processes or a plurality of malodorous pollution processes.
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Patent Agency Ranking
公开(公告)号：US20240101974A1
公开(公告)日：2024-03-28
申请号：US18469527
申请日：2023-09-18
Applicant: YONGNONG BIOSCIENCES CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , NINGXIA YONGNONG BIOSCIENCES CO., LTD.
Inventor： Dongzhi WEI , Hualei WANG , Chengjun WU , Qinghai LIU , Jian ZHANG , Zhonghua LUO , Changlei ZHANG
CPC classification number: C12N9/0024 , C12N9/0065 , C12N15/70 , C12P13/04 , C12Y104/01005 , C12Y111/01006
Abstract: Embodiments of the present disclosure relate to a D-amino acid oxidase mutant and application in preparing L-glufosinate thereof. The D-amino acid oxidase mutant has an amino acid substitution at at least one of position 62 and position 226 of an amino acid sequence of the D-amino acid oxidase mutant when compared to an amino acid sequence of a D-amino acid oxidase as set forth in SEQ ID NO. 1, the position 62 and position 226 being defined with reference to SEQ ID NO. 1, and the amino acid sequence of the D-amino acid oxidase mutant having at least 90% identity to SEQ ID NO. 1.
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公开(公告)号：US11918992B2
公开(公告)日：2024-03-05
申请号：US17770645
申请日：2020-11-23
Applicant: ZHEJIANG WYNCA CHEMICAL INDUSTRY GROUP CO., LTD , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventor： Zhenmin Cheng , Shengbao Jiang , Shenluan Yu , Shuguang Zhou , Minhai Tu , Long Qin , Zhichao Jin , Zibin Huang , Meichen Chen , Peiqing Yuan
CPC classification number: B01J8/226 , B01J8/1872 , B01J2208/0084
Abstract: The present application discloses a multi-region plasma shell-and-tube reactor comprising a shell body. At least two reaction regions are provided inside the shell body, and a horizontal separation panel is provided between any two adjacent reaction regions, used to separate the two and passing through the tubes. A central hole is provided in the center of any horizontal separation panel, and at least one auxiliary hole distributed around the central axis of the central hole is provided in any horizontal separation panel so as to cooperate with the central hole to cause a vortex state to be formed in a reaction region.
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公开(公告)号：US20230365449A1
公开(公告)日：2023-11-16
申请号：US18245575
申请日：2020-09-17
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI HUACHANG ENVIRONMENTAL PROTECTION CO., LTD , SINOPEC GUANGZHOU ENGINEERING CO., LTD.
Inventor： Hualin WANG , Wenjie LV , Jiangi CHEN , Yu LIU , Lei SHI , Ligong QIAO , Jie ZHANG , Guoping CHANG , Zhihong DANG , Yujie JI , Hongpeng MA , Xin CUI , Weichi SANG , Jinsong WANG
CPC classification number: C02F9/00 , B01D47/00 , C02F2303/16 , C02F11/122
Abstract: Disclosed are a fluidized bed separation method and device for methanol-to-olefins quenched water. The method may subject quenched water to liquid-solid separation via a micro-cyclone separator. The method may also subject clear liquid from the micro-cyclone separator to a secondary separation via a fluidized bed separator, then sending the same to an olefin separation device, then recovering some waste heat of the quenched water, and then returning the same to a quenching tower after performing heat exchange. The method may also regenerate a separation medium by reversely feeding stripping tower purified water or quenched water, so as to release catalyst particles absorbed by the separation medium. The method may also send a catalyst slurry concentrated by the micro-cyclone separator and the fluidized bed separator to a filter-press unit for filter-press dehydration, so as to recover a catalyst.
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公开(公告)号：US20230324373A1
公开(公告)日：2023-10-12
申请号：US17904505
申请日：2021-02-09
Inventor： Yi Yang , Yuzheng Zhao , Xie Li , Zeyi Zhang , Xiuze Zhang , Li Huang
IPC: G01N33/53 , G01N33/533 , C07K14/245
CPC classification number: G01N33/5308 , G01N33/533 , C07K14/245
Abstract: Disclosed in the present invention are a pyruvic acid optical probe, a preparation method therefor, and an application thereof. One aspect of the present invention is the disclosure of an optical probe, which includes a pyruvic acid-sensitive polypeptide and an optically active polypeptide, wherein the optically active polypeptide is located within the sequence of the pyruvic acid-sensitive polypeptide. The present invention also discloses a preparation method for the probe and an application of said probe in pyruvic acid measurement.
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公开(公告)号：US20230321103A1
公开(公告)日：2023-10-12
申请号：US18043419
申请日：2021-09-01
Inventor： Honglin LI , Zhenjiang ZHAO , Yanyan DIAO , Zhuo CHEN
IPC: A61K31/519
CPC classification number: A61K31/519
Abstract: Provided is the use of a series of pteridinones and/or a pharmaceutically acceptable salt and a prodrug thereof as a non-canonical EGFR mutant inhibitor. Specifically, the present invention relates to the use of a series of compounds as represented by formula I and a pharmaceutical composition containing the series of compounds as represented by formula I in the preparation of a drug for treating a disease containing EGFR 20insX mutation, EGFR G719X mutation and ERBB2 mutation.
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