公开(公告)号：US20250127693A1

公开(公告)日：2025-04-24

申请号：US18919734

申请日：2024-10-18

Applicant: South Dakota Board of Regents

Inventor： Grigoriy Sereda

IPC: A61K8/19 ,  A61K8/02 ,  A61K8/21 ,  A61K8/34 ,  A61K8/42 ,  A61K8/43 ,  A61K8/63 ,  A61Q11/00

Abstract: Disclosed herein are dentifrices with low pH-triggered release of pharmacons and other materials to more effectively adhere to the tooth and associated surfaces. The various compositions and methods include novel dental compositions that release materials such as fluoride ions, eugenol, pharmacons or other medicinal payloads under physiologically low pH to extend the material lifespan on the teeth and gums of the user.

公开(公告)号：US20250049885A1

公开(公告)日：2025-02-13

申请号：US18782811

申请日：2024-07-24

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： TUGBA OZDEMIR ,  BETH BLAKE

IPC: A61K38/17 ,  A61K47/54 ,  A61L26/00 ,  A61L27/10 ,  A61L27/34

Abstract: Articles, such as implants and medical devices, treated with a hyaluronic acid binding peptide are provided. Articles are coated with a surface functionalizing agent which bind to and immobilize the hyaluronic acid binding peptide. Methods of improving and/or reducing foreign body reaction to an article are also provided, as are methods of decreasing inflammation, promoting wound healing, and treating dermal conditions.

公开(公告)号：US20240425186A1

公开(公告)日：2024-12-26

申请号：US18828464

申请日：2024-09-09

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： Haiping Hong ,  Christian Widener ,  Gregory Lee Christensen

IPC: B64D31/06 ,  B64D31/04 ,  B64D31/08 ,  B64D43/00 ,  C08K3/04 ,  C08K3/38 ,  C09D5/24 ,  C09D7/61 ,  C09D133/02 ,  C09D163/00 ,  C09D175/04 ,  G05D1/652

Abstract: Disclosed herein is a conductive coating composition that includes a functionalized carbon nanomaterial and/or boron nanomaterial and a fluid component. The nanomaterial and fluid component forms hydrogen bond network in the disclosed composition. Because of the formed hydrogen bonds, the disclosed coating exhibits enhanced thermal or electrical conductivity. Also disclosed is a method to improve thermal or electrical conductivity of an existing coating composition.

公开(公告)号：US11955626B2

公开(公告)日：2024-04-09

申请号：US17404796

申请日：2021-08-17

Applicant: South Dakota Board of Regents

Inventor： Alevtina Smirnova ,  Abu Md Numan-Al-Mobin

IPC: H01M4/00 ,  H01M4/136 ,  H01M4/36 ,  H01M4/58 ,  H01M4/62 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0562 ,  H01M4/02

CPC classification number: H01M4/366 ,  H01M4/136 ,  H01M4/5825 ,  H01M4/625 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0562 ,  H01M2004/028 ,  H01M2300/008

Abstract: The present disclosure relates to mixed ionically and electronically conducting solid-state phases for their application in electrochemical devices, such as lithium-metal or lithium ion batteries. The solid-state mixed phase comprises of active cathode and carbon-based structures functionalized by a heteropolyacid (HPA) or a metal salt of a heteropolyacid (Me-HPA) to form a solid-state architecture with incorporated ceramic or glass-ceramic electrolyte for enhanced ionic and electronic conductivity pathways. Combining the solid-state phase components in melted solid-state electrolyte results in perfect distribution, improved adhesion between particles, and improved characteristics of the electrochemical device, such as high charge rates, long-term performance, and broad voltage window.

公开(公告)号：US20240043779A1

公开(公告)日：2024-02-08

申请号：US18487600

申请日：2023-10-16

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： SCOTT WOOD ,  RAM SARASWAT

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12

CPC classification number: C12M23/16 ,  B01L3/502715 ,  C12M23/22 ,  C12M25/14

Abstract: A platform for culturing modular, biomimetic compositions such as tissues, cartilage, bone, synovial membrane, is accomplished through the use of a 3D printed platform with cell well, well plate frame with culture and analysis modules, coverglass bottoms for imaging, and cross-talk flow to connect tissue modules for paracrine signaling. Human chondrocytes can be generated and kept in a cell back and expanded to zonal models, osteoarthritis progression models. The use of titanium oxide nanotubes and can produce bone marrow stem cells differentiated toward osteoblasts. The synovial membrane can be modeled by an electrospun mesh, macrophages with an inducible phenotype (quiescent vs. wound repair vs. inflammatory).

公开(公告)号：US11781698B2

公开(公告)日：2023-10-10

申请号：US16953237

申请日：2020-11-19

Applicant: South Dakota Board of Regents

Inventor： Hadi Fekrmandi ,  Phillip Hillard ,  Skye Rutan-Bedard

IPC: F16L55/34 ,  B62D57/032 ,  F16L101/30

CPC classification number: F16L55/34 ,  B62D57/032 ,  F16L2101/30

Abstract: A modular pipe-crawling robot for in-pipe maintenance operations in aspects of the present disclosure may have one or more of the following features: (a) at least two locomotion modules, (b) each module has feet which can extend outward to grip a wall of a pipe while simultaneously reducing its length or disengaging its feet from the inner wall while increasing its length, (c) a gear mechanism built into mechanical linkage, wherein each module's feet are held perpendicular with respect to the inner wall of the pipe, and (d) a joint coupling the at least two modules.

公开(公告)号：US20230295456A1

公开(公告)日：2023-09-21

申请号：US18185152

申请日：2023-03-16

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： WHYTNEIGH DUFFIE ,  TRAVIS WALKER ,  TSVETANKA FILIPOVA ,  TIMOTHY BRENZA ,  KEVIN BARZ

IPC: C09D135/02 ,  C08F22/04 ,  C09D4/00 ,  B33Y70/00

CPC classification number: C09D135/02 ,  C08F22/04 ,  C09D4/00 ,  B33Y70/00

Abstract: The present disclosure relates to photo-curable resins, and, more particularly, to 3D-printable, surface-eroding, acrylic anhydride-based resins, including both acrylated and methacrylated chemistries. In a preferred embodiment, the resins compositions are degradeable. The disclosure also provides methods of preparing the photo-curable resins and embodiments of degradeable objects comprised of the photo-curable resins.

公开(公告)号：US20230036959A1

公开(公告)日：2023-02-02

申请号：US17790934

申请日：2021-01-04

Applicant: SOUTH DAKOTA BOARD OF REGENTS TECHNOLOGY TRANSFER OFFICE

Inventor： Joy Scaria

IPC: C12Q1/04 ,  C12Q1/18 ,  A61K35/742 ,  C12N1/20

Abstract: A composition and method for identifying a microbial composition that inhibits colonization of an enteric pathogen in an animal is disclosed. The method includes removing a microbial sample from a digestive tract of at least one healthy individual, culturing the microbial sample, isolating one or more microbial species within the microbial sample, and identifying one or more isolated microbial species. The method further includes determining one or more bile-tolerant properties of the one or more isolated microbial species, and creating one or more microbial compositions of the one or more isolated microbial species that are bile-tolerant. The method further includes determining an ability of the one or more microbial compositions to inhibit growth of an enteric pathogen in at least one of an assay, and identifying one or more microbial compositions from the one or more microbial compositions capable of inhibiting growth of enteric pathogens in an animal.

公开(公告)号：US11506326B2

公开(公告)日：2022-11-22

申请号：US17251638

申请日：2018-06-13

Applicant: South Dakota Board of Regents

Inventor： Christian Widener ,  Bharath Jasthi ,  Dimeji Oladepo

IPC: F16L55/18 ,  C23C24/04 ,  F16L55/168 ,  B05B7/14

Abstract: A method of repairing an active leak in embodiments of the present invention may include one or more of the following steps: (a) identifying the active leak on a pipe structure, tank or pressure vessel, (b) setting cold spray system settings to repair the pipe structure, (c) administering pressurized gas and metal powder to an active pipe leak, (d) identifying any potential hazards surrounding the active pipe leak, (e) eliminating and/or reducing the potential hazards surround the active pipe leak, (f) inserting a wedge within an active leak pipe hole, (g) ceasing administration of pressurized gas and metal powder to the active pipe leak when it appears sealed, (h) verifying the active pipe leak is sealed, and (i) re-administering the pressurized gas and the metal powder to the active leak is the active leak is not fully sealed.

公开(公告)号：US11292925B2

公开(公告)日：2022-04-05

申请号：US16381861

申请日：2019-04-11

Applicant: South Dakota Board of Regents

Inventor： Haiping Hong ,  Christian Widener ,  Gregory Lee Christensen

IPC: C09D5/24 ,  C09D133/02 ,  C09D163/00 ,  C09D7/61 ,  C09D175/04 ,  C08K3/04 ,  C08K3/38

Abstract: Disclosed herein is a conductive coating composition that includes a functionalized carbon nanomaterial and/or boron nanomaterial and a fluid component. The nanomaterial and fluid component forms hydrogen bond network in the disclosed composition. Because of the formed hydrogen bonds, the disclosed coating exhibits enhanced thermal or electrical conductivity. Also disclosed is a method to improve thermal or electrical conductivity of an existing coating composition.