CARDIAC VALVE PROSTHESIS
    2.
    发明公开

    公开(公告)号:US20240041593A1

    公开(公告)日:2024-02-08

    申请号:US18256618

    申请日:2021-12-09

    申请人: GROWNVALVE GMBH

    发明人: Boris SCHMITT

    IPC分类号: A61F2/24 A61L27/36

    摘要: It is provided a cardiac valve prosthesis, obtainable by a method comprising the following steps: a) providing human or animal body tissue, b) shaping the body tissue in a shaping process to give the body tissue a shape and size of a cardiac valve, c) fixation and stabilization of the body tissue by a cross-linking agent, thereby preserving the shape given to the body tissue by the shaping process and thus obtaining a cardiac valve prosthesis. In this context, the cross-linking agent comprises at least one compound having a structure according to general formula (I).

    Method for locating on a cornea an artificial lens fabricated from a
collagen-hydrogel for promoting epithelial cell growth
    8.
    发明授权
    Method for locating on a cornea an artificial lens fabricated from a collagen-hydrogel for promoting epithelial cell growth 失效
    在角膜上定位由胶原 - 水凝胶制成的用于促进上皮细胞生长的人造镜片的方法

    公开(公告)号:US4994081A

    公开(公告)日:1991-02-19

    申请号:US511847

    申请日:1990-04-16

    摘要: A method for locating on the cornea an optical lens having a preselected geometric shape and power wherein the optical lens is formed of a collagen-hydrogel for promoting epithelial cell growth is shown. The method comprises the steps of: removing from Bowman's membrane over the area of the pupillary zone of the eye a portion of the corneal epithelium; forming on Bowman's membrane a "V" shaped annular groove having a diameter substantially equal to the maximum geometrical dimensions of the optical lens and a preselected depth; dissecting the peripheral edge of the groove forming a wing of corneal tissue having a preselected length; placing the posterior surface of the optical lens on the anterior surface of Bowman's membrane and positioning the outer edge of the optical lens under the corneal wing, and affixing the optical lens to Bowman's membrane over the pupillary zone of the eye to maintain the same on the cornea with the corneal wing overlying the edge of the optical lens. With the edge of the lens in contact with corneal epithelim, the collagen-hydrogel for promoting epithelial cell growth interacts with epithelial cells during a healing period to promote growth thereof over, and attach to, the anterior surface of the optical lens implanting the same under corneal epithelium.

    摘要翻译: 示出了在角膜上定位具有预选几何形状和功率的光学透镜的方法,其中光学透镜由用于促进上皮细胞生长的胶原 - 水凝胶形成。 该方法包括以下步骤:在眼睛的瞳孔区域的一部分角膜上皮上去除Bowman膜; 在Bowman膜上形成具有基本上等于光学透镜的最大几何尺寸的直径和预选深度的“V”形环形槽; 解剖形成具有预选长度的角膜组织翼的槽的周边边缘; 将光学透镜的后表面放置在Bowman膜的前表面上,并将光学透镜的外边缘定位在角膜下方,并将光学透镜粘贴在Bowman's膜上,在眼睛的瞳孔区域上保持相同 角膜与角膜覆盖光学透镜的边缘。 随着镜片边缘与角膜上皮接触,用于促进上皮细胞生长的胶原 - 水凝胶在愈合期间与上皮细胞相互作用,以促进其生长,并附着在植入其中的光学透镜的前表面 角膜上皮。