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    VIRUS PURIFICATION AND FORMULATION PROCESS
    4.
    发明申请
    VIRUS PURIFICATION AND FORMULATION PROCESS 审中-公开

    公开(公告)号：US20160264943A1

    公开(公告)日：2016-09-15

    申请号：US15163288

    申请日：2016-05-24

    申请人： GE Healthcare Bio-Sciences Corp.

    发明人： John J. VICALVI ,  Edward G. Hayman ,  Joseph Makowiecki

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  C12N2770/24151 ,  C12N2770/24163

    摘要： Disclosed herein is provided a virus purification and formulation process for purifying a flavivirus represented by one of a a Yellow Fever Virus, Japanese Encephalitis virus, Dengue virus, and West Nile virus. The highly purified flavivirus virus product is characterized as having a low level of sucrose without significant virus loss such as that which is typically encountered by prior art virus purification processes. The disclosed process captures and purifies the virus, separating it from the host cell proteins and DNA, and leaving the host cell proteins and DNA behind. The process also can be used to inactivate and/or concentrate the virus sufficiently for use in formulations.

    VIRUS PURIFICATION AND FORMULATION PROCESS
    5.
    发明申请
    VIRUS PURIFICATION AND FORMULATION PROCESS 审中-公开
    病毒纯化和制剂工艺

    公开(公告)号：US20150210986A1

    公开(公告)日：2015-07-30

    申请号：US14423394

    申请日：2013-08-16

    申请人： GE Healthcare Bio-Sciences Corp.

    发明人： John J. Vicalvi, JR. ,  Edward G. Hayman ,  Joseph Makowiecki

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  C12N2770/24151 ,  C12N2770/24163

    摘要： Disclosed herein is provided a virus purification and formulation process for purifying a flavivirus represented by one of a a Yellow Fever Virus, Japanese Encephalitis virus, Dengue virus, and West Nile virus. The highly purified flavivirus virus product is characterized as having a low level of sucrose without significant virus loss such as that which is typically encountered by prior art virus purification processes. The disclosed process captures and purifies the virus, separating it from the host cell proteins and DNA, and leaving the host cell proteins and DNA behind. The process also can be used to inactivate and/or concentrate the virus sufficiently for use in formulations.

    摘要翻译： 本文公开了一种用于纯化由黄热病病毒，日本脑炎病毒，登革热病毒和西尼罗河病毒之一表示的黄病毒的病毒纯化和制备方法。 高度纯化的黄病毒病毒产品的特征在于具有低水平的蔗糖而没有显着的病毒损失，例如通过现有技术的病毒纯化方法遇到的那些。 所公开的方法捕获和纯化病毒，将其与宿主细胞蛋白质和DNA分离，并将宿主细胞蛋白质和DNA留在背后。 该方法还可用于使病毒充分灭活和/或浓缩以用于制剂中。

    Compositions, methods and uses for inducing viral growth
    6.
    发明授权
    Compositions, methods and uses for inducing viral growth 有权
    用于诱导病毒生长的组合物，方法和用途

    公开(公告)号：US08871487B2

    公开(公告)日：2014-10-28

    申请号：US12631629

    申请日：2009-12-04

    申请人： Dan T. Stinchcomb ,  Jill A. Livengood ,  O'Neil Wiggan ,  Richard Kinney ,  Jorge Osorio

    发明人： Dan T. Stinchcomb ,  Jill A. Livengood ,  O'Neil Wiggan ,  Richard Kinney ,  Jorge Osorio

    IPC分类号： C12N7/00 ,  A61K39/12

    CPC分类号： C12N7/00 ,  C12N2770/24134 ,  C12N2770/24151

    摘要： Embodiments herein report methods, compositions and uses for inducing and/or accelerating viral growth. In certain embodiments, methods, compositions and uses generally related to copolymer compositions for inducing viral growth, reducing lag time and/or increasing viral plaque size. In other embodiments, methods, compositions and uses of copolymer compositions can be for inducing flaviviral growth, reducing lag in growth and/or increasing plaque size.

    摘要翻译： 本文的实施方案报告用于诱导和/或加速病毒生长的方法，组合物和用途。 在某些实施方案中，方法，组合物和用途通常涉及用于诱导病毒生长，减少滞后时间和/或增加病毒斑块大小的共聚物组合物。 在其它实施方案中，共聚物组合物的方法，组合物和用途可用于诱导黄病毒生长，减少生长滞后和/或增加斑块大小。