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公开(公告)号：US09868745B2
公开(公告)日：2018-01-16
申请号：US14541057
申请日：2014-11-13
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： A61K31/4188 , C07D491/052 , A61K45/06 , A61K31/7056 , A61K38/21 , C07F5/02 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , C07D405/12 , A61K47/60
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US09809600B2
公开(公告)日：2017-11-07
申请号：US15207415
申请日：2016-07-11
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila M. Zipfel
IPC分类号： C07D491/052 , C07D405/12
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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3.发明授权Method for treating a mammal by administration of a compound having the ability to release CO 有权通过给予具有释放CO能力的化合物来治疗哺乳动物的方法公开(公告)号：US09023402B2
公开(公告)日：2015-05-05
申请号：US13078735
申请日：2011-04-01
IPC分类号： A61K33/00 , A61K33/24 , A61K31/28 , A61K31/665 , A61K31/67 , A61K31/675 , C07F17/00 , A61K31/00 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/48 , C07F11/00 , C07F13/00 , C07F15/02
CPC分类号： C07F17/00 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/52 , C07F11/005 , C07F13/005 , C07F15/02 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/879 , Y10S514/886 , Y10S514/887 , Y10S514/894 , Y10S514/903 , Y10S514/921 , Y10S514/929 , Y10S514/95 , Y10S514/958 , Y10S514/959 , Y10S514/964 , A61K2300/00
摘要： Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
摘要翻译： 几类体内释放一氧化碳的化合物可用于治疗和/或预防疾病，例如慢性炎症，例如类风湿性关节炎，以及具有强烈炎症成分的疾病，例如动脉粥样硬化，中风，冠状动脉疾病， 和阿尔茨海默病。 体内释放一氧化碳的化合物可以连接到已知的药物载体和/或已知的抗炎药物，例如阿司匹林。
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公开(公告)号：US08921341B2
公开(公告)日：2014-12-30
申请号：US14049133
申请日：2013-10-08
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： A01N43/16 , A61K31/35 , A01N33/18 , A01N33/24 , A61K31/04 , C07D207/46 , A61K45/06 , A61K31/4188 , C07D491/052 , A61K31/7056 , A61K38/21
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本公开涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20130164260A1
公开(公告)日：2013-06-27
申请号：US13679862
申请日：2012-11-16
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Kanata , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： A61K31/4188 , A61K45/06
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130156732A1
公开(公告)日：2013-06-20
申请号：US13679874
申请日：2012-11-16
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： A61K45/06 , A61K31/4188 , C07D491/052
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US07638305B2
公开(公告)日：2009-12-29
申请号：US11550652
申请日：2006-10-18
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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公开(公告)号：US07588776B2
公开(公告)日：2009-09-15
申请号：US12038132
申请日：2008-02-27
申请人： Shih-Lan Hsu
发明人： Shih-Lan Hsu
CPC分类号： A61K36/41 , Y10S514/838 , Y10S514/893 , Y10S514/894
摘要： A pharmaceutical composition containing a water-soluble fraction of Graptopetalum and its use in treating a liver disease or condition, such as inflammation, steatosis, and fibrosis.
摘要翻译： 含有Graptopetalum的水溶性级分的药物组合物及其在治疗肝脏疾病或病症如炎症，脂肪变性和纤维化中的用途。
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公开(公告)号：US20090169508A1
公开(公告)日：2009-07-02
申请号：US12400344
申请日：2009-03-09
申请人： Edwin S.C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
发明人： Edwin S.C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
IPC分类号： A61K31/485 , C07D489/00 , A61K38/21 , A61P25/04
CPC分类号： C07D221/28 , A61K31/485 , A61K38/21 , A61K45/06 , C07D453/00 , C07D489/00 , C07D489/02 , C07D489/08 , Y10S514/893 , Y10S514/894 , A61K2300/00
摘要： The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage.
摘要翻译： 本发明涉及阿片样物质和阿片样物质化合物及其药物制剂及其用于预防和治疗诸如败血性休克和器官损害的病症的用途。
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公开(公告)号：US07544779B2
公开(公告)日：2009-06-09
申请号：US11549531
申请日：2006-10-13
申请人： Lowell J. Brady , Kevin M. Klucher , Chung-leung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung-leung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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