公开(公告)号：US12201922B2

公开(公告)日：2025-01-21

申请号：US17687237

申请日：2022-03-04

Applicant: Sartorius Stedim Chromatography Systems Ltd.

Inventor： Fabrizio Pelella ,  Jason Forte ,  Mark Allen Pagkaliwangan

IPC: B01D15/18 ,  B01D15/14 ,  B01D15/22 ,  G01N30/20 ,  G01N30/26 ,  G01N30/46 ,  G01N30/60 ,  G01N30/88

Abstract: A method for operating a chromatography setup of a bioprocess installation with a plurality of chromatography columns, each with a column inlet and a column outlet, and a valve switching cassette with a group of inlet ports, a group of outlet ports, a group of column-in ports and a group of column-out ports. It is prosed, that a first liquid stream of concentrated buffer is introduced into a first internal liquid line via a first inlet port and that a second liquid stream of diluent is introduced into a second internal liquid line via a second inlet port, that in a dilution process, the array of valve units is switched as to create a third liquid stream by merging the first liquid stream and the second liquid stream at a merging location within the valve switching cassette.

公开(公告)号：US12140513B2

公开(公告)日：2024-11-12

申请号：US17962723

申请日：2022-10-10

Applicant: SHIMADZU CORPORATION

Inventor： Yukio Oikawa ,  Shigeyoshi Horiike

IPC: G01N1/40 ,  G01N30/02 ,  G01N30/32 ,  G01N30/74 ,  B01D61/00 ,  C07K1/16 ,  C07K1/34 ,  C07K1/36 ,  C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  G01N30/08 ,  G01N30/14 ,  G01N30/26 ,  G01N30/84

Abstract: A concentrator includes a casing, a separation membrane that sections an inner space of the casing to form a flow path in the casing, a first supplier that supplies a first liquid from a first position of the casing to the flow path such that the first liquid flows along the separation membrane in a first direction, a second supplier that supplies a second liquid from a second position of the casing to the flow path such that the second liquid flows along the separation membrane in a second direction opposite to the first direction, and a third supplier that supplies a third liquid including a target component having a size that does not allow permeation of the target component through the separation membrane from a third position of the casing to the flow path.

公开(公告)号：US20230333070A1

公开(公告)日：2023-10-19

申请号：US18026659

申请日：2021-09-14

Applicant: SEKISUI CHEMICAL CO., LTD. ,  SEKISUI MEDICAL CO., LTD.

Inventor： Shoutarou KOBARU ,  Takamasa KOUNO ,  Nobuhiko INUI ,  Kazuhiko IMAMURA ,  Sou YAMAGUCHI ,  Katsura UCHIDA ,  Tatsunori TAKAMATSU

IPC: G01N35/08 ,  G01N30/26

CPC classification number: G01N30/26 ,  G01N35/08

Abstract: Provided is an inspection chip with simplified channel switching structure, which is generally complicated. An inspection chip 1 including a chip main body 2 having a specimen introduction channel, an adsorption channel including an adsorption unit, a first waste liquid channel, a recovery liquid introduction channel, and a detection channel including a detection unit; and a rotary valve 3 attached to the chip main body 2 so as to be rotatable about a rotation axis, the rotary valve 3 having a plurality of connection channels, the plurality of connection channels being arranged so that the rotary valve 3 is capable of taking at least a first state and a second state when the rotary valve 3 rotates about the rotation axis, the first state being a state in which the specimen introduction channel, the adsorption channel, and the first waste liquid channel are connected so as to be provided in this order from an upstream side, and the second state being a state in which the recovery liquid introduction channel, the adsorption channel, and the detection channel are connected so as to be provided in this order from the upstream side.

公开(公告)号：US20220326195A1

公开(公告)日：2022-10-13

申请号：US17641679

申请日：2020-11-18

Applicant: SHIMADZU CORPORATION

Inventor： Akira AONO ,  Shota HATA ,  Naru MARUOKA ,  Hideki SATO

IPC: G01N30/20 ,  G01N30/88 ,  G01N30/26

Abstract: A switching mechanism 110 can perform switching to a pressurized state in which gas is supplied from a pipe 203 to an insertion tube 101, or a derivation state in which gas in a head space 23 that is pressurized is derived from the insertion tube 101 to the pipe 207 via a collection unit 104. The switching mechanism 110 includes a discharge valve 103 that puts the insertion tube 101 and the pipe 207 into a non-communication state in the pressurized state and puts the insertion tube 101 and the pipe 207 into a communication state in the derivation state. A resistance pipe 206 supplies gas to a channel between the collection unit 104 and the discharge valve 103 in the derivation state.

公开(公告)号：US11460455B2

公开(公告)日：2022-10-04

申请号：US15525613

申请日：2015-11-11

Applicant: Cytiva Sweden AB

Inventor： Lena Nyholm ,  Johan Arthursson ,  Eva Olsson ,  Ulrika Ohman

IPC: G01N30/86 ,  G01N30/26 ,  G01N30/50

Abstract: Method for determining the influence of least a first and a second experimental parameter on a liquid chromatography protocol for purifying one or more target molecules from a sample, comprising the steps: —performing chromatography purifications of the sample at a plurality of different experimental conditions where at least the first and the second experimental parameter each are varied over a predetermined range, each purification being registered as a chromatogram by monitoring an output parameter indicative of the purification result during the purification; and—displaying in a graphical user interface at least a subset of the registered chromatograms as chromatogram-miniatures in an evaluation diagram wherein the position of each displayed chromatogram-miniature is determined by the experimental parameters for the corresponding purification, thereby allowing a user to visually determine trends and the influence of the experimental parameters on the liquid chromatography protocol.

公开(公告)号：US20200319152A1

公开(公告)日：2020-10-08

申请号：US16768136

申请日：2018-11-29

Applicant: UCL BUSINESS LTD

Inventor： Stuart Ibsen ,  Alaric Taylor ,  Simon Dawes ,  Luis Antonio Serrano Gonzalez ,  Stefan Guldin

IPC: G01N30/90 ,  G01N30/74 ,  G01N30/14 ,  G01N30/26 ,  G01N1/40 ,  G01N33/94

Abstract: The invention relates to cartridges for thin layer chromatography (TLC) which hermetically seal the TLC mobile phase during loading, performance of the TLC process, and analysis of the chromatogram. It further relates to associated methods of use—for example for detecting or quantifying an analyte in a sample. It further relates to processes for assembling the cartridge, to associated equipment adapted for use with them, and kits of parts.

公开(公告)号：US10364900B2

公开(公告)日：2019-07-30

申请号：US15038895

申请日：2015-01-22

Applicant: Hitachi High-Technologies Corporation

Inventor： Takaaki Hara ,  Hiroshi Moriya ,  Ayano Otsubo ,  Yoshihiro Nagaoka ,  Kiyotoshi Mori ,  Shoji Tomita

IPC: F16K3/06 ,  G01N30/20 ,  F16K11/074 ,  G01N30/26 ,  G01N30/38

Abstract: Provided are: a flow path switching valve that reduces the pressure load in a contact surface outer peripheral section of the flow path switching valve and inhibits friction between constituent components; and a liquid chromatographic device using the flow path switching valve. The flow path switching valve is provided with a stator having a plurality of through holes and a seal having conduction grooves for causing the through holes to conduct. The seal has a first portion present vertically beneath a region comprising at least a surface of contact with the stator, and a second portion having lower rigidity than the first portion, on the outside of the first portion. Due to this configuration, it is possible to reduce the pressure load when a flow path of a liquid is switched under high-pressure conditions, and inhibit the phenomenon of friction itself.

公开(公告)号：US20190170683A1

公开(公告)日：2019-06-06

申请号：US16323532

申请日：2017-12-13

Applicant: Panasonic Intellecutal Property Management Co., Ltd.

Inventor： TOSHIHIRO SAKAMOTO ,  CHIAKI SHIDO

IPC: G01N27/447 ,  G01N30/26 ,  G01N30/88 ,  G01N30/92 ,  G01N30/94 ,  G01N33/543

Abstract: Provided is a thin layer chromatography plate that makes it possible to separate a plurality of components from each other more simply and more quickly. Thin layer chromatography plate includes substrate and separation layer that is disposed on substrate for separating multiple components included in a sample from each other. Separation layer has first layer that has a band shape and extends in first development direction and second layer that extends in second development direction orthogonal to first development direction. Second layer is in contact with first layer. First layer includes a hydrophilic porous body. Second layer includes a hydrophobic porous body.

公开(公告)号：US20190145941A1

公开(公告)日：2019-05-16

申请号：US15815039

申请日：2017-11-16

Applicant: Shimadzu Corporation

Inventor： Shingo MASUDA

IPC: G01N30/26 ,  G05D7/06 ,  G01N30/68

CPC classification number: G01N30/26 ,  G01N30/10 ,  G01N30/32 ,  G01N30/68 ,  G01N2030/025 ,  G01N2030/324 ,  G01N2030/6013 ,  G05D7/06

Abstract: When a flow rate of a carrier gas calculated by a column flow rate calculation unit is controlled to be a first flow rate, and when the flow rate of the carrier gas is controlled to be a second flow rate, the flow rates of the carrier gas are detected by a whole flow rate detection unit, and a gas leakage determination unit determines of leakage of the carrier gas on the basis of the rates. Since the flow rate of the carrier gas is changed and the detected value of the whole flow rate detection unit is used at different flow rates, a case can be discriminated where an offset occurs in the detected value of the whole flow rate detection unit and a case where leakage of the carrier gas occurs. Thus, it is satisfactorily determined the presence or absence of the leakage of the carrier gas.

公开(公告)号：US09664655B2

公开(公告)日：2017-05-30

申请号：US14093691

申请日：2013-12-02

Applicant: Dionex Corporation

Inventor： John M. Riviello

IPC: G01N30/02 ,  G01N30/26 ,  G01N30/96 ,  B01D15/16 ,  B01D15/36

CPC classification number: G01N30/96 ,  B01D15/16 ,  B01D15/36 ,  G01N2030/965

Abstract: Electrolytic eluent recycle systems for ion chromatography using a multi-channel electrolytic ion exchange device which integrates suppression, eluent generation, and eluent recycle. The systems recycle the eluent into the analytical system without passing the eluent through the electrode chambers. Also, such systems with a channel for electrolytic removal of ions from the suppression effluent before recycle.