公开(公告)号：US07408153B2

公开(公告)日：2008-08-05

申请号：US11324231

申请日：2006-01-04

Applicant: Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

Inventor： Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

IPC: H01J44/04 ,  G01N24/00

CPC classification number: H01J49/0027 ,  H01J49/0077 ,  Y10T436/24

Abstract: An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided.An organic acid or an organic acid salt is used to generate an organic acid gas from an organic acid gas generator 3 to be mixed with a sample gas for introduction into an ion source 4 for ionization, thereby obtaining a mass spectrum by a mass analysis region 5. A data processor 6 determines the detection or non-detection of a specific m/z of an organic acid adduct ion obtained by adding a molecule generated from the organic acid to a molecule with specific m/z generated from a target chemical substance to be detected based on the obtained mass spectrum. When there is an ion peak with the m/z of the organic acid adduct ion, the presence of the target chemical substance to be detected is determined, and an alarm is sounded.False detection can be prevented.

Abstract translation: 提供一种用于检测灵敏度和选择性高的化学物质的装置。 使用有机酸或有机酸盐从有机酸气体发生器3产生有机酸性气体，与用于引入离子源4的样品气体混合，从而通过质量分析区域获得质谱 5。 数据处理器6确定通过将由有机酸产生的分子加入到由待检测的目标化学物质产生的具有特定m / z的分子而获得的有机酸加合物的特定m / z的检测或非检测 基于获得的质谱。 当存在有机酸加合离子的m / z的离子峰时，确定要检测的目标化学物质的存在，并发出报警。 可以防止误检。

公开(公告)号：US07015464B2

公开(公告)日：2006-03-21

申请号：US10780880

申请日：2004-02-19

Applicant: Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

Inventor： Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

IPC: H01J44/04 ,  G01N24/00

CPC classification number: H01J49/0027 ,  H01J49/0077 ,  Y10T436/24

Abstract: An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided. An organic acid or an organic acid salt is used to generate an organic acid gas from an organic acid gas generator to be mixed with a sample gas for introduction into an ion source for ionization, thereby obtaining a mass spectrum by a mass analysis region. A data processor determines the detection or non-detection of a specific m/z of an organic acid adduct ion obtained by adding a molecule generated from the organic acid to a molecule with specific m/z generated from a target chemical substance to be detected based on the obtained mass spectrum. When there is an ion peak with the m/z of the organic acid adduct ion, the presence of the target chemical substance to be detected is determined, and an alarm is sounded. False detection can be prevented.

Abstract translation: 提供一种用于检测灵敏度和选择性高的化学物质的装置。 使用有机酸或有机酸盐从有机酸性气体发生器产生有机酸气体，并与用于引入离子源的样品气体混合，从而通过质量分析区域获得质谱。 数据处理器确定通过将由有机酸产生的分子加入到由待检测的目标化学物质产生的特定m / z的分子获得的有机酸加合物的特定m / z的检测或非检测基础上 在获得的质谱上。 当存在有机酸加合离子的m / z的离子峰时，确定要检测的目标化学物质的存在，并发出报警。 可以防止误检。

公开(公告)号：US6104028A

公开(公告)日：2000-08-15

申请号：US86993

申请日：1998-05-29

Applicant: Joanna M. Hunter ,  Hua Lin ,  Christopher H. Becker

Inventor： Joanna M. Hunter ,  Hua Lin ,  Christopher H. Becker

IPC: G01N1/00 ,  H01J49/04 ,  H01J49/16 ,  H01J44/04

CPC classification number: H01J49/164 ,  H01J49/0468 ,  G01N1/22

Abstract: A sample preparation method is disclosed for volatilization and mass spectrometric analysis of nonvolatile high molecular weight molecules. Photoabsorbing molecules having significant sublimation rates at room temperature under vacuum, and preferably containing hydroxy functionalities, are disclosed for use as matrices in matrix-assisted laser desorption/ionization mass spectrometry. The samples are typically cooled in the mass spectrometer to temperatures significantly below room temperature.

Abstract translation: 公开了用于非挥发性高分子量分子的挥发和质谱分析的样品制备方法。 公开了在真空下，优选含有羟基官能团的具有显着升华速率的光吸收分子，用作基质辅助激光解吸/电离质谱法中的基质。 样品通常在质谱仪中冷却至明显低于室温的温度。

公开(公告)号：US5260571A

公开(公告)日：1993-11-09

申请号：US835970

申请日：1992-02-20

Applicant: John S. Cottrell ,  Kuldip K. Mock

Inventor： John S. Cottrell ,  Kuldip K. Mock

IPC: G01N1/28 ,  H01J44/04

CPC classification number: H01J49/0418 ,  G01N1/28

Abstract: A sample for analysis by Laser Desorption Mass Spectrometry is prepared by applying a substrate material to a target for the mass spectrometer, dissolving the sample material in a solvent and applying the solution to a substrate material on the target to be absorbed thereby. A matrix material is also dissolved in a solvent and this matrix material in solution is applied to the substrate material on the target. The solvent used to dissolve the matrix material is chosen such as to release the sample material from the substrate so that, after evaporation of the matrix material, there is provided on the substrate material an intimately mixed deposit of sample material and matrix material.

Abstract translation: PCT No.PCT / GB90 / 00974 Sec。 371日期1992年2月20日 102（e）日期1992年2月20日PCT提交1990年6月25日PCT公布。 出版物WO91 / 02961 1991年3月7日。用于通过激光解吸质谱法分析的样品通过将基底材料施加到质谱仪的靶上，将样品材料溶解在溶剂中并将溶液施加到靶上的基底材料上来制备 被吸收。 将基质材料也溶解在溶剂中，将该溶液中的基质材料施加到靶材上的基材上。 选择用于溶解基质材料的溶剂，以便从基底释放样品材料，使得在基质材料蒸发之后，在基材上提供样品材料和基体材料的紧密混合沉积物。

公开(公告)号：US5965883A

公开(公告)日：1999-10-12

申请号：US924477

申请日：1997-08-25

Applicant: Sang-Won Lee ,  Thomas Schindler ,  Jesse L. Beauchamp

Inventor： Sang-Won Lee ,  Thomas Schindler ,  Jesse L. Beauchamp

IPC: H01J49/04 ,  H01J44/04

CPC classification number: H01J49/167

Abstract: A capillary for use with an electrospray ion source includes a concentric outer capillary sleeve and inner capillary tube. An outer surface of the tube engages an inner surface of the sleeve. Conductors are formed at respective upstream and downstream ends of the capillary.

Abstract translation: 用于电喷雾离子源的毛细管包括同心的外毛细管套管和内毛细管。 管的外表面与套筒的内表面接合。 在毛细管的各个上游和下游端形成导体。

公开(公告)号：US5854486A

公开(公告)日：1998-12-29

申请号：US775016

申请日：1996-12-27

Applicant: Russell W. Dreyfus

Inventor： Russell W. Dreyfus

IPC: G01N1/00 ,  G01N1/36 ,  H01J49/16 ,  H01J44/04

CPC classification number: H01J49/0418 ,  G01N1/36

Abstract: A thin uniform film of matrix material is deposited from the gas phase on to a substrate for use in Matrix Assisted Laser Desorption and Ionization (MALDI) spectroscopy. The thin uniform film of material may be overcoated with another film of material which has a higher vapor pressure than the matrix material to prevent the matrix material from evaporating during storage and during substantial time in the vacuum environment of the mass spectrometer.

Abstract translation: 将基质材料的薄均匀膜从气相沉积到用于基质辅助激光解吸和电离（MALDI）光谱的基底上。 材料的薄均匀膜可以用另一种具有比基体材料更高的蒸气压的材料膜覆盖，以防止基质材料在储存期间和在质谱仪的真空环境中的实质时间内蒸发。