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1.发明公开公开(公告)号：US20240245646A1
公开(公告)日：2024-07-25
申请号：US18522503
申请日：2023-11-29
IPC分类号： A61K31/404 , A61K9/00 , A61K31/4184 , A61P25/00 , A61P29/00 , C07D235/18
CPC分类号： A61K31/404 , A61K9/0053 , A61K31/4184 , A61P25/00 , A61P29/00 , C07D235/18
摘要： The present invention is directed to a method for preventing and/or treating aging-related cognitive impairment in the central nervous system. The method comprises administering to a subject in need thereof a Ppangela activator 2-(4-tert-butylphenyl)-1H-benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, in an effective amount. A preferred route of administration is oral administration.
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公开(公告)号：US20240239760A1
公开(公告)日：2024-07-18
申请号：US18387913
申请日：2023-11-08
发明人： James E. Audia , Jonathan E. Wilson
IPC分类号： C07D263/57 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/472 , C07D217/04 , C07D235/18 , C07D249/20 , C07D277/66 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
CPC分类号： C07D263/57 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/472 , C07D217/04 , C07D235/18 , C07D249/20 , C07D277/66 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Provided are compounds of Formula (I):
and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with PPARG.-
公开(公告)号：US20230331705A1
公开(公告)日：2023-10-19
申请号：US17999254
申请日：2021-05-19
发明人： Alessandra Bartolozzi , John Robert Proudfoot , Timothy Briggs , John Mancuso , Maxence Bos , Vu Linh Ly , Anna Blois , Bernard Lanter , Steven John Taylor , Leonard Buckbinder
IPC分类号： C07D403/12 , A61K45/06 , C07D235/18 , A61P35/04
CPC分类号： C07D403/12 , A61K45/06 , C07D235/18 , A61P35/04
摘要： The present disclosure relates to compounds of formulae (I)-(VI) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.
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4.发明公开公开(公告)号：US20230150951A1
公开(公告)日：2023-05-18
申请号：US17909589
申请日：2021-03-08
申请人： OM PHARMA SA
发明人： Jacques BAUER , Olivier MARTIN
IPC分类号： C07D251/20 , C07C235/64 , C07C229/38 , C07C233/51 , C07C275/42 , C07C309/51 , C07C317/46 , C07D235/18
CPC分类号： C07D251/20 , C07C235/64 , C07C229/38 , C07C233/51 , C07C275/42 , C07C309/51 , C07C317/46 , C07D235/18
摘要： The present invention provides novel hydroquinone derivatives of formula (I), processes of preparation, as well as pharmaceutical compositions and methods of treating and/or preventing e.g. autoimmune, immunological, rheumatology, vascular disorders, ophthalmologic disorders, fibrotic disorders, metabolic and gastrointestinal disorders, neuroinflammatory and neurodegenerative diseases, neoplasms and cancer associated disorders, hormone related diseases and immunological disorders resulting from viral and bacterial infectious diseases and complications thereof. wherein R1 is COOR4, (CH2)nCOOR4, SO3H, (CH2)nSO3H or CONH—R10; one of R2 and R3 is H and the other is R5.
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公开(公告)号：US20230150944A1
公开(公告)日：2023-05-18
申请号：US16972220
申请日：2019-06-06
发明人： Andrew EDMUNDS , Michel MUEHLEBACH , Sebastian RENDLER , Anke BUCHHOLZ , Daniel EMERY , Vikas SIKERVAR , Girish RAWAL , Indira SEN
IPC分类号： C07D235/18 , C07D471/04 , C07D487/04 , C07D401/04 , C07D263/54 , A01N43/52 , A01N43/90 , A01N43/76
CPC分类号： C07D235/18 , C07D471/04 , C07D487/04 , C07D401/04 , C07D263/54 , A01N43/52 , A01N43/90 , A01N43/76
摘要： Compounds of the formula (I), wherein the substituents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling animal pests, including arthropods and in particular insects, nematodes, molluscs or representatives of the order Acarina.
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公开(公告)号：US20230002427A1
公开(公告)日：2023-01-05
申请号：US17825866
申请日：2022-05-26
发明人： Jaemin MOON , Inbum SONG , Dohan KIM , Sungjin PARK , Yong Woo KIM , Seokhyeon YU
IPC分类号： C07F15/00 , C07C211/54 , C07F1/02 , C07D209/82 , C07D235/18 , H01L51/00
摘要： Disclosed is an organometallic compound represented by a following Chemical Formula I, wherein the compound is a metal complex including a central coordination metal and a main ligand binding thereto, wherein the main ligand has a structure in which a fused ring is further introduced into 2-phenylquinoline. When the organometallic compound is used as dopant of a light-emitting layer of an organic electroluminescent device, rigidity is imparted to the organometallic compound molecule such that a full width at half maximum (FWHM) is narrow and thus color purity is improved. Further, a non-luminescent recombination process is reduced such that luminous efficiency and lifespan of the organic electroluminescent device are improved. Chemical Formula I is shown below:
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公开(公告)号：US11498903B2
公开(公告)日：2022-11-15
申请号：US16639145
申请日：2018-08-16
IPC分类号： C07D235/16 , C07D413/12 , C07D413/10 , C07D471/04 , C07D491/056 , C07D473/00 , C07D235/18
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.
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公开(公告)号：US20220320446A1
公开(公告)日：2022-10-06
申请号：US17701627
申请日：2022-03-22
发明人： Jaesung LEE , Soobyung KO , Sungbum KIM , Haejin KIM , Eunsoo AHN , Mina JEON
IPC分类号： H01L51/00 , C07F15/00 , C07D209/82 , C07D405/12 , C07D401/12 , C07C211/54 , C07D409/12 , C07D307/91 , C07F7/08 , C07D487/14 , C07C255/31 , C07C15/28 , C07C15/38 , C07D333/76 , C07C13/62 , C07D403/10 , C07D403/14 , C07D401/14 , C07D491/048 , C07D495/04 , C07D471/04 , C07C15/30 , C07D251/24 , C07F3/00 , C07D493/04 , C07D213/74 , C07D213/38 , C07D235/18 , C07D401/04 , C07D401/10 , C07D239/26 , C07D215/12 , C07D519/00 , C07F5/06 , C07D249/08 , C07F1/02
摘要： A light-emitting device includes: a first electrode; a second electrode facing the first electrode; an interlayer between the first electrode and the second electrode and including an emission layer; and an organometallic compound of Formula 1: wherein, in Formula 1, the variables are described herein.
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公开(公告)号：US20220298162A1
公开(公告)日：2022-09-22
申请号：US17664305
申请日：2022-05-20
IPC分类号： C07D487/04 , A61K45/06 , C07D231/56 , C07D235/18 , C07D519/00
摘要： The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.
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公开(公告)号：US11370794B2
公开(公告)日：2022-06-28
申请号：US16348816
申请日：2017-11-09
IPC分类号： C07D487/04 , A61K45/06 , C07D231/56 , C07D235/18 , C07D519/00
摘要： The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I), and pharmaceutical compositions thereof, are antagonists of toll-like receptors such as TLR7, TLR8, and/or TLR9. In certain embodiments, compounds of the invention are useful for inhibiting immune response and treating diseases associated with undesirable immune response.
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