公开(公告)号：US11614428B2

公开(公告)日：2023-03-28

申请号：US16841369

申请日：2020-04-06

申请人： DIONEX SOFTRON GMBH

发明人： Christoph Hollnagel

IPC分类号： G01N30/24 ,  G01N30/20 ,  G01N30/46 ,  G01N30/16 ,  G01N30/60 ,  G01N30/32 ,  G01N30/02 ,  G01N30/38 ,  G01N30/36 ,  G01N30/22

摘要： A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.

公开(公告)号：US20220317101A1

公开(公告)日：2022-10-06

申请号：US17702849

申请日：2022-03-24

申请人： SHIMADZU CORPORATION

发明人： Shiori UEDA ,  Tomohiro SHAGAWA ,  Soichiro TAMAOKI

IPC分类号： G01N30/86 ,  G01N30/82 ,  G01N30/16

摘要： A separation column (6), an injector (4) that injects a sample into a mobile phase flowing through a flow path (16) leading to the separation column (6), at least one detector (8;10) that is fluidly connected downstream of the separation column (6), and generates a plurality of detector signals different from each other derived from a component in a sample separated by the separation column (6), a fraction collector (12) for fractionating and collecting a portion containing a component separated by the separation column (6) in an eluate from the separation column (6) into an individual collection container, and a controller (14) that detects a component peak in a plurality of chromatograms based on each of a plurality of the detector signals and controls operation of the fraction collector (12) based on a result of the detection are included. The controller (14) includes a fractionating collection part (26) configured to execute fractionating collection in which a portion detected as a component peak only in one chromatogram of a plurality of the chromatograms and a portion detected as a component peak in all of a plurality of the chromatograms are collected separately in collection containers different from each other.

公开(公告)号：US20220276208A1

公开(公告)日：2022-09-01

申请号：US17749839

申请日：2022-05-20

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Edward D. MROZ ,  Heng HE

IPC分类号： G01N30/16 ,  G01N30/68

摘要： A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.

公开(公告)号：US11361953B2

公开(公告)日：2022-06-14

申请号：US16051171

申请日：2018-07-31

申请人： QUEST DIAGNOSTICS INVESTMENTS LLC

发明人： Darren Weber ,  Nigel Clarke

IPC分类号： H01J49/00 ,  H01J49/42 ,  G01N30/32 ,  B01D15/16 ,  B01D15/20 ,  B01D15/42 ,  G01N30/16 ,  G01N33/68

摘要： Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

公开(公告)号：US20210372973A1

公开(公告)日：2021-12-02

申请号：US17399693

申请日：2021-08-11

申请人： Northwest Institute of Eco-Environment and Resources, CAS

发明人： Yingqin WU ,  Yanhong LIU ,  Tong WANG ,  Zuodong WANG ,  Longmiao YUAN ,  Zhiyu WANG

IPC分类号： G01N30/72 ,  B01J20/22 ,  G01N30/16 ,  B01J20/281

摘要： A method for separating diastereomers of pristane. A pristane sample is prepared, and then injected into a chromatographic instrument equipped with a chiral chromatographic column, where a stationary phase of the chiral chromatographic column has a preset pore size. The pristane diastereomers in the pristane sample are separated by the chiral chromatographic column, and the components produced by the separation of the pristane diastereomers sequentially enter a mass spectrometer for detection and analysis.

公开(公告)号：US11162922B2

公开(公告)日：2021-11-02

申请号：US16054522

申请日：2018-08-03

申请人： SHIMADZU CORPORATION

发明人： Kohji Okada

IPC分类号： G01N30/16 ,  G01N30/02

摘要： Before start of analysis, a user inputs pipe capacity difference relative to reference pipe capacity and separation conditions, such as a mobile phase flow rate. A control unit calculates retention time shift from the pipe capacity difference and the flow rate. The control unit controls sample injection and data processing units so as to start collection of chromatogram data when a correction time has passed from the time point of sample injection in the case in which the value of the retention time shift is a positive value, and to perform sample injection when a correction time has passed from the time point at which the collection of chromatogram data is started in the case in which the value of the retention time shift is a negative value. Retention time shift caused by difference in the pipe capacity is corrected even when the mobile phase flow rate is different.

公开(公告)号：US20210325351A1

公开(公告)日：2021-10-21

申请号：US17273181

申请日：2019-12-02

申请人： Zhejiang University

发明人： Qun FANG ,  Di Qiong JIN ,  Jian Zhang PAN ,  Guan Sheng DU

IPC分类号： G01N30/16 ,  G01N30/72 ,  G01N30/06

摘要： The present invention discloses a chromatographic analysis device based on a multifunctional integrated probe, and a use method of the chromatographic analysis device. The chromatographic analysis device integrates chromatographic sampling, sample injection and separation functions into the integrated probe. Meanwhile, the present invention further discloses a method for performing microsample analysis by the chromatographic analysis device based on the multifunctional integrated probe. The present invention has the main advantages as follows: the device is high in integration level, small in dead volume, simple in structure, convenient to use and particularly suitable for microsample analysis with a small sample amount, provides a new chromatographic sample injection mode for chromatographic analysis, and provides an ideal platform for chromatographic analysis and on-site chromatographic analysis of a trace amount of samples.

公开(公告)号：US20210310999A1

公开(公告)日：2021-10-07

申请号：US17272973

申请日：2019-08-30

申请人： SHIMADZU CORPORATION ,  THE UNIVERSITY OF TOKYO

发明人： Keiko MATSUMOTO ,  Yuta SHIMANAKA ,  Nozomu KONO ,  Hiroyuki ARAI

IPC分类号： G01N30/34 ,  B01J20/24 ,  B01J20/32 ,  G01N30/72 ,  G01N30/16 ,  G01N30/06 ,  B01D15/40

摘要： Provided is a method for separating PIPs by which isomers of PIPs can be separated without deacylating the PIPs. The method includes at least a separation step of injecting a sample containing a plurality of PIPs into an analysis flow path of a supercritical fluid chromatograph having a separation column filled with a separation medium containing β-cyclodextrin and separating the plurality of PIPs by supercritical fluid chromatography.

公开(公告)号：US20210072199A1

公开(公告)日：2021-03-11

申请号：US17048671

申请日：2019-01-16

申请人： SHIMADZU CORPORATION

发明人： Yusuke YOKOI ,  Daisuke KITABAYASHI

IPC分类号： G01N30/30 ,  G01N30/32 ,  G01N30/16

摘要： A chromatography system includes a liquid sending pump for sending a mobile phase in an analysis flow path, a sample injector that injects a sample into the analysis flow path, a separation column for separating the sample into components, a column oven for storing the separation column and adjusting a temperature of the separation column to a preset target temperature, a liquid sending controller configured to control an operation of the liquid sending pump, and a column protection flow rate setter configured to set a column protection flow rate. The liquid sending controller is configured to control the operation of the liquid sending pump such that, when the liquid sending pump starts sending the mobile phase, the flow rate of the mobile phase flowing through the analysis flow path does not exceed the column protection flow rate until a temperature in the column oven reaches the target temperature.

公开(公告)号：US10900937B2

公开(公告)日：2021-01-26

申请号：US15768085

申请日：2016-10-11

申请人： bentekk GmbH

发明人： Matthias Schmittmann ,  Johannes Weber ,  Arne Jünemann ,  Paul Weber

IPC分类号： G01N30/32 ,  G01N30/16 ,  G01N30/38 ,  G01N33/00 ,  G01N30/88 ,  G01N30/00 ,  G01N30/02

摘要： A portable gas analysis apparatus for conducting a gas flow, in particular for highly volatile compounds, includes a seeker measurement path and a separation measurement path. The seeker measurement path extends from a sample gas inlet opening to a first air exit opening, wherein a connecting path branches off from the seeker measurement path to a separation measurement path, and said separation measurement path extends from the connecting path to a second air exit opening and is connected to a carrier gas inlet opening, wherein the gas analysis apparatus has a control element which is designed for reversing the gas flow in the connecting path.