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公开(公告)号：US20240319191A1
公开(公告)日：2024-09-26
申请号：US18731669
申请日：2024-06-03
发明人： Daniel Jones , Kevin J. Arvai , Ya-Hsuan Hsu
IPC分类号： G01N33/574 , C12Q1/6886
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N2333/47 , G01N2333/916 , G01N2800/52 , G01N2800/56
摘要： Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.
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公开(公告)号：US12077830B2
公开(公告)日：2024-09-03
申请号：US18097004
申请日：2023-01-13
发明人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb
CPC分类号： C12Q1/701 , A61P31/14 , C12N7/00 , C12Q1/68 , C12Q1/686 , C12Q1/70 , G01N33/56983 , A61K39/00 , C12N2770/16021 , C12Q2600/106 , C12Q2600/112 , G01N2333/08 , C12Q1/686 , C12Q2521/107 , C12Q1/70 , C12Q2521/107
摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
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公开(公告)号：US12025610B2
公开(公告)日：2024-07-02
申请号：US17234448
申请日：2021-04-19
发明人： Dov Shiffman , Carmen Tong , James J. Devlin , Michael J. McPhaul
CPC分类号： G01N33/492 , G01N30/7266 , G01N33/6848 , G01N33/74 , G01N2333/62 , G01N2800/042 , G01N2800/50
摘要： Methods are described for diagnosing or prognosing insulin resistance in diabetic and pre-diabetic patients, the method comprising determining the amount of insulin and C-peptide in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
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公开(公告)号：US12018402B2
公开(公告)日：2024-06-25
申请号：US16325856
申请日：2017-08-17
IPC分类号： C40B30/04 , A61K31/03 , A61K31/48 , A61K31/567 , A61K31/4174 , A61K31/4439 , A61K31/444 , A61K31/451 , A61K31/496 , A61K31/506 , C12Q1/6806 , C12Q1/6886
CPC分类号： C40B30/04 , A61K31/03 , A61K31/48 , A61K31/567 , A61K31/4174 , A61K31/4439 , A61K31/444 , A61K31/451 , A61K31/496 , A61K31/506 , C12Q1/6806 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The present technology is related to methods for detecting genetic alterations underlying intracranial neoplasms such as pituitary adenomas, meningiomas, and craniopharyngiomas. The methods disclosed herein are useful in determining whether a patient harboring an intracranial tumor will benefit from or is predicted to be responsive to treatment with an individual therapeutic agent or a specific combination of therapeutic agents. Kits for use in practicing the methods are also provided.
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公开(公告)号：US11965212B2
公开(公告)日：2024-04-23
申请号：US17500858
申请日：2021-10-13
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q1/6886 , C12Q2531/113 , C12Q2521/301
摘要： Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are oligonucleotides and kits useful in the method. Exemplary nucleic acid targets are those with mutant gene sequence such as mutant sequence of the EGFR, APC, TMPRSS2, ERG and ETV1 genes.
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公开(公告)号：US11959143B2
公开(公告)日：2024-04-16
申请号：US17103544
申请日：2020-11-24
发明人： Kevin Qu , Anthony Sferruzza , Ke Zhang , Yan Liu , Renius Owen
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.
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公开(公告)号：US20240118294A1
公开(公告)日：2024-04-11
申请号：US18543588
申请日：2023-12-18
发明人： Karin O. Thomassian
IPC分类号： G01N33/94 , A61K31/785 , H01J49/00
CPC分类号： G01N33/94 , A61K31/785 , G01N33/9493 , H01J49/0036 , G01N2560/00
摘要： A method for determining an amount of teriflunomide in a sample by mass spectrometry includes adding an internal standard to the sample, subjecting the sample to solid phase extraction, purifying the sample by high turbulence liquid chromatography, ionizing the sample to produce one or more teriflunomide ions detectable by mass spectrometry, determining the amount of the one or more teriflunomide ions by mass spectrometry, and using the amount of the one or more ions determined to further determine the amount of teriflunomide in the sample.
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8.发明公开公开(公告)号：US20240085386A1
公开(公告)日：2024-03-14
申请号：US18509590
申请日：2023-11-15
发明人： Thomas C. Lynn
CPC分类号： G01N30/7266 , G01N30/72 , G01N30/7233 , G01N30/88 , G01N33/70 , G01N2030/045 , G01N2560/00
摘要： Provided are methods for detecting or determining the amount of guanidinoacetate (GAA), creatine, and creatinine by mass spectrometry.
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公开(公告)号：US20240019433A1
公开(公告)日：2024-01-18
申请号：US18473600
申请日：2023-09-25
发明人： Stanley J. NAIDES , Joanna Popov
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/56944 , G01N33/686 , G01N33/6893 , G01N2800/38 , G01N2469/20 , G01N2333/315
摘要： Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of ELAVL2, ELAVL3, ELAVL4, Nova-1, Nova-2, Cdr1, Cdr2; and Cdr3. The presence of such autoantibodies is indicative of a positive diagnosis for a post-streptococcal disease such as PANDAS, post-GABHS glomerulonephritis, rheumatic fever, autism and Syndenham's chorea.
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公开(公告)号：US20230417700A1
公开(公告)日：2023-12-28
申请号：US18214420
申请日：2023-06-26
IPC分类号： G01N27/447 , G06V20/69
CPC分类号： G01N27/44721 , G06V20/695 , G06V20/698
摘要： The present solution describes an automated system for analyzing analytical gels or blots, such as electrophoresis gels. The system can automatically detect the lanes within the gel and convert the lane into a feature vector that can be compared to reference datasets. Based on a comparison of the feature vector to the reference datasets, the system can automatically classify the feature vector (and the test sample in the lane) into a phenotype group.
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