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公开(公告)号：US20100121130A1
公开(公告)日：2010-05-13
申请号：US12691508
申请日：2010-01-21
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A prescription method of treating tissue comprises the steps of accepting a prescription tissue treatment plan for the tissue to be treated, positioning seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan, and creating a treatment strand by heating and cooling a material to position the plurality of treatment seeds in the material. The prescription tissue treatment plan specifies a number and a spacing of the seeds to be provided in the treatment strand, the spacing of the treatment seeds being unrestricted by any use of spacers and independently set by and according to the prescription tissue treatment plan.
摘要翻译： 处理组织的处方方法包括以下步骤：接受处理组织的处方组织处理计划，根据处方组织处理计划相对于彼此定位种子，使得种子相对于彼此的位置仅由 处方组织处理计划，以及通过加热和冷却材料以将多种处理种子定位在材料中来形成治疗股。 处方组织处理计划规定了要在治疗链中提供的种子的数量和间距，处理种子的间距通过任何使用间隔物而不受限制，并且根据处方组织处理计划独立设定。
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公开(公告)号：US20090304770A1
公开(公告)日：2009-12-10
申请号：US12373412
申请日：2007-07-16
申请人： Andrew Lennard Lewis , Sean Willis , Stephen Alister Jones , Vincent James O'Byrne , David Micheal Grey , Michael John Driver , Samantha Ryan , Richard Paul Redman
发明人： Andrew Lennard Lewis , Sean Willis , Stephen Alister Jones , Vincent James O'Byrne , David Micheal Grey , Michael John Driver , Samantha Ryan , Richard Paul Redman
CPC分类号： C08F220/18 , C08F212/08 , C08F220/14
摘要： A novel class of polymers obtainable by copolymerising a monomer mixture comprising (i) hydrophilic monomer of general formula (I) Y—B—X; (ii) styrene or a substituted styrene, a monomer or mixture of monomers which when polymerised form a polymer with a Tg lower than the Tg of a homopolymer of monomer (I) and lower than the Tg of a homopolymer of monomer (ii); and a monomer having a crosslinkable group is described. The invention also relates to a method for producing such polymers, implants coated with the polymers and methods for forming the same.
摘要翻译： 通过共聚单体混合物获得的一类新型聚合物，其包含（i）通式（I）Y-B-X的亲水性单体; （ii）苯乙烯或取代的苯乙烯，当聚合形成Tg低于单体（I）的均聚物的Tg并低于单体（ii）的均聚物的Tg）的聚合物时的单体或单体的混合物; 并描述具有可交联基团的单体。 本发明还涉及一种生产这种聚合物的方法，用该聚合物涂覆的种植体及其形成方法。
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93.发明授权公开(公告)号：US07540998B2
公开(公告)日：2009-06-02
申请号：US10987141
申请日：2004-11-12
CPC分类号： A61L2/206 , A61N5/1027 , A61N2005/1011
摘要： A process is provided for sterilizing brachytherapy devices with Ethylene Oxide gas and releasing the devices on a parametric release basis. Devices that can be sterilized with this process include interstitial radiation seed strand implants and the needles used for implantation. In order to be sterilized effectively by EtO gas, the devices are constructed such that surfaces not readily infused with EtO gas are made to be gas permeable, and will not retain the gas after the sterilization process. Performance qualification of the sterilization process is performed through physical and microbiological studies, and set of established physical process parameters. Maintaining the physical process parameters in subsequent sterilization cycles will consistently yield the desired sterility assurance level without having to test the devices for sterility.
摘要翻译： 提供了一种使用环氧乙烷气体灭菌近距离放射治疗装置并以参数释放为基础释放装置的方法。 可以用该方法灭菌的装置包括间质辐射种子线植入物和用于植入的针。 为了通过EtO气体有效灭菌，这些装置被构造成使得不容易注入EtO气体的表面被制成透气性，并且在灭菌过程之后不会保留气体。 灭菌过程的性能鉴定通过物理和微生物学研究以及既定的物理过程参数进行。 在随后的灭菌循环中保持物理过程参数将一直产生所需的无菌保证水平，而无需测试设备的无菌性。
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94.发明申请IMPLANTS FOR USE IN BRACHYTHERAPY AND OTHER RADIATION THERAPY THAT RESIST MIGRATION AND ROTATION 有权用于BRACHYTHERAPY和其他辐射治疗的植入物，可抵抗移动和旋转公开(公告)号：US20090099402A1
公开(公告)日：2009-04-16
申请号：US12335435
申请日：2008-12-15
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： In an embodiment a therapeutic member includes a solitary radioactive seed. The seed includes a metallic housing with radioactive material contained within the metallic housing. The metallic housing has a first longitudinal end and a second longitudinal end and a longitudinal length between the first and second longitudinal ends. A polymeric material is molded to completely and monolithically encapsulate the metallic housing of the solitary radioactive seed. The implantable therapeutic member is adapted to be implanted into patient tissue using a hollow needle. A portion of the molded polymeric material extends from one of the first and second longitudinal ends of the metallic housing to reduce a tendency of the seed to migrate and rotate within a patient's body after implantation of the member. The portion of the molded polymeric material, that extends from one of the first and second longitudinal ends of the metallic housing, causes the implantable therapeutic member to have a longitudinal length that is greater than the longitudinal length of the metallic housing.
摘要翻译： 在一个实施方案中，治疗构件包括孤立的放射性种子。 种子包括金属外壳，放射性材料包含在金属外壳内。 金属壳体具有第一纵向端部和第二纵向端部以及在第一和第二纵向端部之间的纵向长度。 将聚合物材料模制成完全和整体地包封孤立的放射性种子的金属壳体。 可植入治疗构件适于使用中空针植入患者组织。 模制的聚合物材料的一部分从金属外壳的第一和第二纵向端之一延伸，以减少种植物在植入构件之后在患者体内迁移和旋转的倾向。 模制聚合物材料的从金属外壳的第一和第二纵向端之一延伸的部分使可植入治疗构件的纵向长度大于金属外壳的纵向长度。
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公开(公告)号：US20080305176A1
公开(公告)日：2008-12-11
申请号：US12159013
申请日：2007-01-24
IPC分类号： A61K9/14 , A61K31/337 , A61K31/19 , A61K31/56 , A61P29/00
CPC分类号： A61K9/1635 , A61K9/1694 , A61K31/192 , A61K31/337 , A61K31/573
摘要： The present invention relates to processes for loading microsphere polymer particles with crystallisable drug, in the presence of a crystallisation inhibitor whereby crystallisation of the drug is inhibited. The invention is of particular value for loading polymer beads with paclitaxel, ibuprofen and/or dexamethasone. The polymer is suitably an anionic polyvinyl alcohol polymer.
摘要翻译： 本发明涉及在结晶抑制剂存在下加载具有可结晶药物的微球聚合物颗粒的方法，从而抑制药物的结晶。 本发明对于用紫杉醇，布洛芬和/或地塞米松加载聚合物珠粒具有特别的价值。 聚合物合适地是阴离子聚乙烯醇聚合物。
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公开(公告)号：US20060057198A1
公开(公告)日：2006-03-16
申请号：US10546723
申请日：2004-02-23
申请人： Andrew Lewis , Peter Stratford , Simon Leppard
发明人： Andrew Lewis , Peter Stratford , Simon Leppard
IPC分类号： A61K9/26
CPC分类号： A61K31/421 , A61K9/1635 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/365 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/5415 , A61K31/60 , A61K31/603
摘要： A pharmaceutical composition for uterine fibroid embolisation comprises a polymer and, associated with the polymer in a releasable form, a COX inhibitor, e.g. a non-steroidal anti inflammatory drug, such as ibuprofen. The polymer is preferably in particulate form, such as in the form of microspheres. A suitable polymer is a crosslinked polyvinyl alcohol polymer formed by the copolymerisation of PVA macromer with other ethylenically unsaturated monomers. The composition provides a synergistic treatment for the symptoms of uterine fibroids, leading to size regression as well as pain relief.
摘要翻译： 用于子宫肌瘤栓塞的药物组合物包含聚合物，并且与可释放形式的聚合物相关联，例如COX抑制剂。 非甾体抗炎药，如布洛芬。 聚合物优选为颗粒形式，例如以微球的形式。 合适的聚合物是通过PVA大分子单体与其它烯属不饱和单体的共聚形成的交联聚乙烯醇聚合物。 该组合物为子宫肌瘤的症状提供协同治疗，导致大小消退以及疼痛缓解。
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公开(公告)号：US06852816B2
公开(公告)日：2005-02-08
申请号：US10398400
申请日：2001-10-05
IPC分类号： A61K9/10 , A61K47/32 , C08F4/40 , C08F20/22 , C08F246/00 , C08F293/00 , C08F130/02
CPC分类号： C08F4/40 , C08F246/00 , C08F293/005 , C08F2438/01
摘要： Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2′-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.
摘要翻译： 聚合物可以由具有受控结构和分子量的两性离子单体制备，使用活性聚合如基团或原子转移自由基聚合。 例如聚合物可以通过使用氯化铜催化剂，水溶性配体和水溶性叔烷基卤引发剂的原子转移自由基聚合形成，以形成控制多分散度小于1.5的均聚物和具有其它亲水或疏水性的嵌段共聚物 单体。 一种合适的两性离子单体是2-甲基丙烯酰氧基-2'-三甲基铵乙基磷酸内酯盐。 嵌段共聚物可以自发形成胶束，据信其具有两性离子，例如磷酸胆碱，在外表面的基团，其可用作具有改善的生物相容性的药物递送系统。
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公开(公告)号：US20210221928A1
公开(公告)日：2021-07-22
申请号：US17252564
申请日：2019-06-26
发明人： Andrew Lennard Lewis , Jasmine Lord
IPC分类号： C08F112/14 , C08F116/06 , A61K49/04 , A61B17/12
摘要： A liquid composition comprising a polymer having pendant groups of the formula I: (I) Wherein X is either a bond or is a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; and n is 1 to 4.
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99.发明申请公开(公告)号：US20210212763A1
公开(公告)日：2021-07-15
申请号：US17145304
申请日：2021-01-09
摘要： Various aspects of the present disclosure are directed apparatuses, systems, and methods that may include a microwave ablation system. The microwave ablation system may include a microwave ablation needle, a controller, a microwave generator configured to provide ablation power to the microwave ablation needle, and a pump configured to provide a coolant to the microwave ablation needle at a flow rate, such that the microwave ablation needle emits microwave radiation based on the received ablation power and the controller is configured to perform a plurality of predefined processes having an associated applied ablation power and coolant flow rate.
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公开(公告)号：US20210038299A1
公开(公告)日：2021-02-11
申请号：US16988168
申请日：2020-08-07
发明人： Tim Bachman , Charles Senness , Dennis Babcock , Jason William Sprain , Luan Chan , Maciej Wojciech Misiak , Winston Tan , Matthew Goulet , Andrew Kevin Zachman , Logan Ernster
IPC分类号： A61B18/14
摘要： The disclosure provides a cooling system for a surgical ablation device, the device having a cooling circuit comprising a device coolant supply line having a supply coupling; a coolant return line having a return coupling; coolant passageways within the device to circulate coolant within the device, the supply line and the return line being in fluid communication via the device coolant passageway(s); a coolant manifold configured to fluidly connect a cooling fluid source to at least one manifold fluid outlet port, such as to place the cooling fluid source in fluid communication with the one or more device coolant passageways, wherein the supply coupling is configured for connection to a manifold outlet port of the manifold.
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