利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

177 条记录 (耗时 0.041 秒)

    METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES
    91.
    发明申请
    METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES 审中-公开
    减少肠道疾病影响的方法和组合

    公开(公告)号：US20110033495A1

    公开(公告)日：2011-02-10

    申请号：US12867622

    申请日：2009-02-14

    申请人： Michael Roof ,  Marc Eichmeyer

    发明人： Michael Roof ,  Marc Eichmeyer

    IPC分类号： A61K39/295 ,  A61K39/12 ,  A61P31/04 ,  A61P31/20

    CPC分类号： A61K39/12 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2750/10034

    摘要： The present invention relates to the use of an immunogenic composition that comprises a PCV2 antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with an enteric infection, even more preferably, with enteric disease. The use relates to a method comprising the steps of administering the composition to an animal in need thereof, preferably prior to disease exposure. Administration of PCV2 antigen, preferably ORF2 of PCV2, lessens the incidence and reduces the severity of the enteric disease.

    摘要翻译： 本发明涉及包含用于治疗几种临床表现（疾病）的PCV2抗原的免疫原性组合物的用途。 优选地，临床表现与肠道感染相关，甚至更优选与肠道疾病相关。 该用途涉及包括以下步骤的方法：优选在疾病暴露之前将组合物施用于有需要的动物。 PCV2抗原，优选PCV2的ORF2的施用降低了发病率，降低了肠道疾病的严重性。

    PCV2 ORF2 VIRUS LIKE PARTICLE WITH FOREIGN AMINO ACID INSERTION
    92.
    发明申请
    PCV2 ORF2 VIRUS LIKE PARTICLE WITH FOREIGN AMINO ACID INSERTION 审中-公开
    PCV2 ORF2病毒样颗粒与外来氨基酸插入

    公开(公告)号：US20110020394A1

    公开(公告)日：2011-01-27

    申请号：US12812590

    申请日：2008-12-31

    申请人： Eric Vaughn ,  Merrill Schaeffer

    发明人： Eric Vaughn ,  Merrill Schaeffer

    IPC分类号： A61K39/12 ,  C07K14/01 ,  C12N15/63 ,  C12P21/00 ,  A61P37/00

    CPC分类号： A61K39/145 ,  A61K39/012 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2760/16034

    摘要： The present invention comprises methods and compositions related to the production and use of amino acid sequences. In particular, PCV2 ORF2 is shown to be useful as a virus-like particle which produces amino acid sequences that retain their immunogenicity or antigenicity when the DNA encoding the PCV2 ORF2 is inserted into an expression system. DNA sequences that are foreign to PCV2 can be attached “in-frame” to the ORF2 DNA and the entire sequence, including the DNA foreign to PCV2, is expressed. It was shown that such sequences retain their antigenicity and therefore their potential utility in immunogenic compositions.

    摘要翻译： 本发明包括与氨基酸序列的生产和使用有关的方法和组合物。 特别地，PCV2 ORF2被证明可用作病毒样颗粒，当将编码PCV2 ORF2的DNA插入到表达系统中时，产生保留其免疫原性或抗原性的氨基酸序列。 对PCV2异源的DNA序列可以“ORB”的“框架”连接，并且表达包含PCV2外来DNA的整个序列。 显示这些序列保留其抗原性并因此保留其在免疫原性组合物中的潜在用途。

    Reduction of concomitant infections in pigs by the use of PCV2 antigen
    93.
    发明授权
    Reduction of concomitant infections in pigs by the use of PCV2 antigen 有权
    通过使用PCV2抗原减少猪伴随感染

    公开(公告)号：US07829274B2

    公开(公告)日：2010-11-09

    申请号：US12198721

    申请日：2008-08-26

    申请人： Vicky Fachinger ,  Knut Elbers ,  Marion Kixmoeller

    发明人： Vicky Fachinger ,  Knut Elbers ,  Marion Kixmoeller

    IPC分类号： C12Q1/70

    CPC分类号： A61K39/12 ,  A61K45/06 ,  A61K2039/552 ,  C12N2750/10034

    摘要： The present invention relates to a method for reducing the percentage of concomitant infections in pigs or a herd of pigs caused by pathogens other than PCV2 comprising the step administering to said pig(s) an effective amount of PCV2 antigen or an immunogenic composition comprising PCV2 antigen. It also refers to a method for improving the resistance of pigs against concomitant infections with pathogens other than PCV2, comprising the step administering to said pig(s) an effective amount of PCV2 antigen or an immunogenic composition comprising PCV2 antigen.

    摘要翻译： 本发明涉及一种降低由除PCV2以外的病原体引起的猪或猪群中伴随感染的百分比的方法，包括向所述猪施用有效量的PCV2抗原或包含PCV2抗原的免疫原性组合的步骤 。 本发明还涉及提高猪抗PCV2以外的病原体的伴随感染的抗性的方法，包括向所述猪施用有效量的PCV2抗原或包含PCV2抗原的免疫原性组合的步骤。

    METHOD OF PREVENTING EARLY LAWSONIA INTRACELLULARIS INFECTIONS
    95.
    发明申请
    METHOD OF PREVENTING EARLY LAWSONIA INTRACELLULARIS INFECTIONS 有权
    预防早发性肝炎细菌感染的方法

    公开(公告)号：US20100266637A1

    公开(公告)日：2010-10-21

    申请号：US12678361

    申请日：2008-09-16

    申请人： Ricarda Deitmer ,  Knut Elbers

    发明人： Ricarda Deitmer ,  Knut Elbers

    IPC分类号： A61K39/02

    CPC分类号： A61K39/105 ,  A61K31/00 ,  A61K31/7048 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/545 ,  A61K2039/552

    摘要： The present invention relates inter alia to the use of a combination of a vaccine against Lawsonia intracellularis and an anti-Lawsonia antibiotic for the prevention or reduction of early, preferably fulminant Lawsonia intracellularis infections. The present invention relates particularly to the use of a live Lawsonia intracellularis vaccine in conjunction with an antibiotic that is effective against Lawsonia intracellularis, for the avoidance or reduction of early Lawsonia intracellularis infections in animals.

    摘要翻译： 本发明尤其涉及使用针对胞内劳森氏菌的疫苗和抗劳森氏菌抗菌素的组合来预防或减少早期，优选暴发性的劳森氏菌细胞内感染。 本发明特别涉及一种活的劳氏细胞内毒素疫苗与抗菌素联合使用，该抗生素对细胞内劳森氏菌有效，以避免或减少动物中早期劳森氏菌感染。

    Porcine reproductive and respiratory syndrome isolates and methods of use
    96.
    发明授权
    Porcine reproductive and respiratory syndrome isolates and methods of use 有权
    猪繁殖与呼吸综合征分离株及其使用方法

    公开(公告)号：US07632636B2

    公开(公告)日：2009-12-15

    申请号：US11022262

    申请日：2004-12-23

    申请人： Michael Roof ,  Eric Vaughn ,  Wesley Johnson

    发明人： Michael Roof ,  Eric Vaughn ,  Wesley Johnson

    IPC分类号： C12Q1/70

    CPC分类号： C12N7/00 ,  C12N2770/10031

    摘要： A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.

    摘要翻译： 提供了一种预测新型或非特异性PRRS病毒株的毒力的方法，其中将菌株注射到猪中并允许复制约3-15天的时间。 在此期间，确定病毒增长率和/或病毒血症的大小，并将该数据与已知毒力的PRRS病毒株的相应生长速率和/或病毒血症量进行比较，作为毒力 新的或未表征的菌株。

    Equine herpesvirus vaccine
    99.
    发明授权
    Equine herpesvirus vaccine 有权
    马疱疹病毒疫苗

    公开(公告)号：US07226604B2

    公开(公告)日：2007-06-05

    申请号：US10897984

    申请日：2004-07-23

    申请人： Mark W. Mellencamp

    发明人： Mark W. Mellencamp

    IPC分类号： A61K39/12

    CPC分类号： C07K16/087 ,  A61K39/12 ,  A61K39/145 ,  A61K39/245 ,  A61K39/27 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K2317/76 ,  C12N2710/16034 ,  C12N2710/16734 ,  C12N2710/16763 ,  C12N2760/16134 ,  C12N2760/16163

    摘要： A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and an adjuvant. The adjuvant can include a cross-linked olefinically unsaturated carboxylic acid polymer which may have bioadhesive properties. The vaccine may also include antigens against other equine pathogens such as inactivated EHV-4 and inactivated A1 and/or A2 strains of equine influenza virus. Methods for protecting horses against diseases associated with EHV-1 and/or EHV-4 and methods of producing the equine herpesvirus vaccine are also provided.

    摘要翻译： 提供了一种用于保护马免受与EHV-1和/或EHV-4有关的疾病的疫苗。 疫苗通常包括灭活的EHV-1（例如化学灭活的EHV-1 KyA病毒）和佐剂。 佐剂可以包括可具有生物粘附性质的交联的烯属不饱和羧酸聚合物。 疫苗还可以包括针对其他马病原体的抗原，例如灭活的EHV-4和灭活的A1和/或A2株马流感病毒。 还提供了用于保护马免受与EHV-1和/或EHV-4相关的疾病的方法和产生马疱疹病毒疫苗的方法。

    Immunogenic compositions comprising Lawsonia intracellularis
    100.
    发明申请
    Immunogenic compositions comprising Lawsonia intracellularis 有权
    包含细胞内劳森氏菌的免疫原性组合物

    公开(公告)号：US20060204522A1

    公开(公告)日：2006-09-14

    申请号：US11374350

    申请日：2006-03-13

    申请人： Jeremy Kroll ,  Mike Roof

    发明人： Jeremy Kroll ,  Mike Roof

    IPC分类号： A61K39/295 ,  A61K39/116

    CPC分类号： A61K39/105 ,  A61K35/74 ,  A61K39/0241 ,  A61K39/0275 ,  A61K39/12 ,  A61K39/295 ,  A61K39/39 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/525 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2750/10034 ,  Y02A50/482 ,  Y10S424/825

    摘要： The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.

    摘要翻译： 本发明提供了组合疫苗，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防至少一种其它疾病的免疫活性成分， 引起猪的生物体。 此外，本发明还涉及一种试剂盒，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防的免疫活性成分 一种另外一种导致猪致病的生物体。