公开(公告)号：US20220162559A1

公开(公告)日：2022-05-26

申请号：US17258820

申请日：2019-07-09

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Ying Mei ,  Dylan Jack Richards

IPC: C12N5/077 ,  C12N5/071

Abstract: This invention relates to three-dimensional myocardial infarct organoids and methods of making and using the same for screening compounds that improve cardiac function and compounds that diminish cardiac function.

公开(公告)号：US11312807B2

公开(公告)日：2022-04-26

申请号：US16512937

申请日：2019-07-16

Applicant: Clemson University Research Foundation

Inventor： Marek W. Urban

IPC: C08F293/00

Abstract: Provided is a copolymer exhibiting self-healing properties. The copolymer comprises first units comprising first pendant groups wherein the first pendant groups are alkyls having at least 1 to no more than 6 carbons. Second units comprising second pendant groups are alkyls having at least 2 to no more than 8 carbons. The first units and second units are in a molar ratio of 45/55 to 55/45 and the pendant groups form an inter-pendant space having a volume of at least 80 Ang.3 to no more than 140 Ang.3. The copolymer comprises no more than 3 adjacent first units and no more than 3 adjacent second units.

公开(公告)号：US20210364444A1

公开(公告)日：2021-11-25

申请号：US16639436

申请日：2018-09-04

Applicant: Clemson University Research Foundation

Inventor： Robert A. Latour ,  George Chumanov ,  Alexandra Czynski

IPC: G01N21/78 ,  G01N33/52 ,  G01N33/70 ,  G01N33/493

Abstract: A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light. Alternatively, the color change can be read by eye and compared to a color chart relating the color to an analyte concentration.

公开(公告)号：US20210161139A1

公开(公告)日：2021-06-03

申请号：US16770442

申请日：2018-12-06

Applicant: North Carolina State University ,  Clemson University Research Foundation

Inventor： Fred H. Yelverton ,  Lambert McCarty

IPC: A01N43/653 ,  A01N33/18 ,  A01N43/90 ,  A01N33/04

Abstract: Disclosed are methods for selectively controlling or modifying the growth of Poa annua in a turf grass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.

公开(公告)号：US10988735B2

公开(公告)日：2021-04-27

申请号：US15543701

申请日：2016-01-15

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development ,  The University of Chicago

Inventor： Ying Mei ,  Tan Yu ,  Dylan Richards ,  Donald R. Menick ,  Bozhi Tian

IPC: C12N5/077 ,  G01N33/50 ,  A61K35/34 ,  A61L27/30 ,  A61L27/38

Abstract: Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.

公开(公告)号：US20200237961A1

公开(公告)日：2020-07-30

申请号：US16849326

申请日：2020-04-15

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： CHRISTOPHER FERNANDEZ ,  JEREMY MERCURI

IPC: A61L27/36 ,  A61F2/44 ,  C12N5/00 ,  A61L27/38

Abstract: Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.

公开(公告)号：US10720255B2

公开(公告)日：2020-07-21

申请号：US15643076

申请日：2017-07-06

Applicant: Clemson University Research Foundation

Inventor： Xiao Ran Zheng ,  Endre Takacs ,  Mark Leising

IPC: G21K1/02 ,  A61N5/10 ,  G21K5/04

Abstract: Radiation delivery devices are described herein having compact and lightweight design in comparison to existing architectures. A radiation delivery device comprises a source body including a plurality of radiation sources and a collimator component for directing radiation from the radiation sources to a common focal area, wherein the radiation sources are arranged within the collimator component. In some embodiments, for example, the source body is positioned within an interior cavity of the collimator component.

公开(公告)号：US20200071544A1

公开(公告)日：2020-03-05

申请号：US16685101

申请日：2019-11-15

Applicant: Clemson University Research Foundation

Inventor： ANDREW MOUNT ,  Bin San Chan ,  Mary Beth Johnstone

IPC: C09D5/16 ,  C07K14/435 ,  C07K7/08

Abstract: Materials and methods for prevention of biofouling that incorporate the presence of a conotoxin peptide on a surface are described. The conotoxin peptide is either directly or indirectly adhered to the surface and interferes with the ability of biofouling organisms to settle on the surface.

公开(公告)号：US20190192432A1

公开(公告)日：2019-06-27

申请号：US16286898

申请日：2019-02-27

Applicant: Clemson University Research Foundation

Inventor： Jeoung Soo Lee

IPC: A61K9/107 ,  A61K9/51 ,  A61K47/69 ,  A61K47/59 ,  A61K45/06 ,  A61P7/02 ,  A61P9/00

CPC classification number: A61K47/488 ,  A61K9/1075 ,  A61K9/5153 ,  A61K31/4015 ,  A61K31/713 ,  A61K45/06 ,  A61K47/482 ,  A61K47/48561 ,  A61K47/593 ,  A61K47/6907 ,  A61K47/6937 ,  A61P7/02 ,  A61P9/00 ,  B82Y5/00 ,  C07K16/2863 ,  C12N15/113

Abstract: Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.

公开(公告)号：US20190190251A1

公开(公告)日：2019-06-20

申请号：US16274941

申请日：2019-02-13

Applicant: Clemson University Research Foundation (CURF)

Inventor： Keith A. Corzine

IPC: H02H3/16 ,  H03K17/687

CPC classification number: H02H3/16 ,  H03K17/687

Abstract: An improved DC circuit breaker is provided for automatically detecting and isolating a fault between a source and a ground. The DC circuit breaker comprises at least one switch, in electrical series with a first inductor between the source and a load, and a second inductor magnetically coupled to the first inductor wherein a first side of the second inductor is electrically connected to the load and a second side of the second inductor is grounded through a capacitor.