公开(公告)号：US10342552B2

公开(公告)日：2019-07-09

申请号：US15150089

申请日：2016-05-09

Applicant: Fortus Medical, Inc. ,  The Cleveland Clinic Foundation

Inventor： Robert Assell ,  Andy Freeman ,  George Muschler

IPC: A61J1/14 ,  A61J1/20 ,  C12M1/33 ,  A61B17/00 ,  A61B17/16 ,  A61B17/88 ,  C12M1/26 ,  A61L27/38 ,  A61M1/00 ,  A61L27/36

Abstract: A tissue collection and processing system for collecting bone fragments and tissue therein. The tissue collection and processing system includes a collection vessel, a collection vessel cap and a filter container. The collection vessel has an opening formed therein. The collection vessel cap is capable of engaging the collection vessel to substantially seal the opening. The collection vessel cap or the collection vessel includes a first port and a second port. The filter container is mounted with respect to the first port.

公开(公告)号：US10335272B2

公开(公告)日：2019-07-02

申请号：US15372602

申请日：2016-12-08

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Eric E. Roselli ,  Douglas R. Johnston

IPC: A61F2/24 ,  A61F2/06 ,  A61F2/07 ,  A61F2/848 ,  A61F2/915

Abstract: An apparatus for repairing the function of a diseased valve includes a tubular first support member which is expandable to a first average diameter and has oppositely disposed proximal and distal first support member ends. A tubular second support member is spaced axially apart from the first support member and is expandable to a second average diameter that is smaller than the first average diameter. The second support member has oppositely disposed proximal and distal second support member ends. A tubular graft section interconnects the first and second support members and has oppositely disposed proximal and distal graft section ends axially spaced apart by a graft section body. The proximal graft section end is connected directly to the distal first support member end and the distal graft section end is connected directly to the proximal second support member end.

公开(公告)号：US20190192115A1

公开(公告)日：2019-06-27

申请号：US16098969

申请日：2017-05-08

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Matthew R. Ford ,  William J. Dupps

IPC: A61B8/10 ,  A61B8/08 ,  A61B3/107 ,  A61B3/00 ,  A61B3/14

CPC classification number: A61B8/10 ,  A61B3/0025 ,  A61B3/107 ,  A61B3/14 ,  A61B3/16 ,  A61B5/0051 ,  A61B5/0097 ,  A61B8/485 ,  A61B8/5215

Abstract: Systems and method are provided for evaluating a biomechanical property of tissue. A shear wave generator induces a shear wave in the tissue. An optical imaging system captures video in the visible light spectrum comprising a series of image frames of the tissue during the shear wave. An image processing component determines, at each of a plurality of locations, a speed at which the shear wave travels within the tissue from the series of image frames. A parameter calculation component calculates a value for the biomechanical property from the determined speed of the shear wave at a plural subset of the plurality of locations.

公开(公告)号：US10304197B2

公开(公告)日：2019-05-28

申请号：US15883626

申请日：2018-01-30

Applicant: The Cleveland Clinic Foundation

Inventor： Vikash R. Goel ,  Donald P. Greenberg ,  Roy K. Greenberg

IPC: G06K9/00 ,  G06T7/13 ,  G06T7/60 ,  G06T17/30 ,  G06T7/37 ,  G06T7/155

Abstract: A computer implemented method for determining a centerline of a three-dimensional tubular structure is described. The method includes providing an edge-detected data set of voxels that characterize a boundary of the tubular structure according to a three-dimensional voxel data set for the tubular structure. A gradient field of a distance transformation is computed for the edge-detected dataset. A voxel data set corresponding to a centerline of the tubular structure is computed according to derivative of gradient field.

公开(公告)号：US10285799B2

公开(公告)日：2019-05-14

申请号：US15487752

申请日：2017-04-14

Applicant: COOK MEDICAL TECHNOLOGIES LLC ,  THE CLEVELAND CLINIC FOUNDATION

Inventor： David E Hartley ,  Roy K Greenberg ,  Krasnodar Ivancev ,  Michael Lawrence-Brown

IPC: A61F2/07 ,  A61F2/856 ,  A61F2/06 ,  A61F2/89

Abstract: A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. There is a step portion (10) between the first body portion and the second body portion. The step portion is joined to and continuous with the first portion and the second portion. A first side of each of the first body portion, the step portion and the second body portion are substantially aligned so that there is a step (18) defined on a second side opposite to the first side of the body portion. There is an aperture (30) in the step portion and an internal tube (32) extending from the aperture towards the first body portion. The internal tube is divided along part of its length into at least two smaller internal tubes (34, 36) with the smaller internal tubes opening into the first lumen.

公开(公告)号：US10258352B2

公开(公告)日：2019-04-16

申请号：US15847206

申请日：2017-12-19

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Joseph P. Iannotti ,  Wael K. Barsoum ,  Jason A. Bryan

IPC: A61B17/17 ,  A61B17/80 ,  A61F2/46 ,  A61B17/88 ,  A61B17/00 ,  A61B17/56 ,  A61B17/90 ,  A61F2/34 ,  A61B34/10

Abstract: A guide for assisting with attachment of a stock prosthetic implant to a patient tissue includes a lower guide surface configured to contact an upper implant surface of the stock prosthetic implant when a lower implant surface of the stock prosthetic implant contacts the patient tissue. An upper guide surface is accessible to a user when the lower guide surface is in contact with the upper implant surface. At least one guiding aperture extends through the guide body between the upper and lower guide surfaces at a predetermined aperture location with respect to the guide body and defines a predetermined target trajectory through the guide body. At least one of the target trajectory and the aperture location of each guiding aperture is preselected responsive to preoperative imaging of the patient tissue. A method of assisting with attachment of a stock prosthetic implant to a patient tissue is also provided.

公开(公告)号：US20190105149A1

公开(公告)日：2019-04-11

申请号：US16155176

申请日：2018-10-09

Applicant: The Cleveland Clinic Foundation

Inventor： Eric E. Roselli ,  Kelly B. Emerton ,  Justin Metcalf ,  Brandon Gulker

IPC: A61F2/07 ,  A61F2/92

Abstract: An endovascular graft including a stent graft and a surgical graft is provided. The stent graft can include an elongated body having a collapsed and expanded configuration and include a frame structure covered by a compression sleeve that retains the elongated body in the collapsed configuration until deployment of the stent graft. The endovascular graft can include a first cuff member sized and dimensioned to extend into a lumen of an aortic arch branch vessel when the endovascular graft is implanted in a subject. The frame structure can include a backstop sized and dimensioned to extend into the first cuff member when the endovascular graft is implanted in the subject. The surgical graft can be partially attached to the stent graft at a proximal end portion thereof.

公开(公告)号：US10213304B2

公开(公告)日：2019-02-26

申请号：US14883819

申请日：2015-10-15

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Samir Kapadia

IPC: A61F2/24 ,  A61M29/02

Abstract: An apparatus for treating regurgitation of blood through a diseased heart valve having at least two leaflets includes a lollipop-shaped body member having a proximal end portion, a distal end portion, and an intermediate portion extending between the end portions. The intermediate portion includes an expandable occluding member having an adjustable diameter so that, during at least a portion of the cardiac cycle, at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve. The proximal end portion is physically connected to the occluding member and includes a connecting mechanism for operably mating with an adjustment member for adjusting the position and diameter of the occluding member within the diseased heart valve. The distal end portion includes an anchoring member for securing the apparatus in a heart chamber containing the diseased heart valve.

公开(公告)号：US10201414B2

公开(公告)日：2019-02-12

申请号：US15710255

申请日：2017-09-20

Applicant: Cook Medical Technologies LLC ,  The Cleveland Clinic Foundation

Inventor： David Ernest Hartley ,  John Lennon Anderson ,  Roy K. Greenberg ,  Wolf Stelter

IPC: A61F2/07 ,  A61F2/954 ,  A61F2/962 ,  A61F2/06 ,  A61F2/95 ,  A61F2/89

Abstract: An introduction arrangement for a fenestrated or branched stent graft (13) intended for deployment into the lumen of a vessel having a blind vessel extending from it. The introducer (1) has a distal end intended to remain outside a patient in use and a proximal end with a nose cone dilator (11) and an arrangement to retain the branched stent graft distally of the nose cone dilator. A sheath (15) on the introducer extends over the branched stent graft to the nose cone dilator. An indwelling catheter (21) extends from the distal end of the introducer and enters the fenestration or side arm and through to the nose cone dilator, the indwelling catheter has a guide wire (29) extending through it. The guide wire can be extended beyond the nose cone dilator in use before the sheath is withdrawn from the branched stent graft so that it can be snared from the contra-lateral artery.

公开(公告)号：US20190038642A1

公开(公告)日：2019-02-07

申请号：US16159102

申请日：2018-10-12

Applicant: The Cleveland Clinic Foundation

Inventor： Stanley L. Hazen

IPC: A61K31/616 ,  A61K31/00 ,  G01N33/49 ,  A61K31/519 ,  A61K31/496 ,  A61K31/13 ,  A61K31/675 ,  A61P13/12 ,  A61K31/4365 ,  A61P9/00 ,  A61K31/43 ,  A61K31/4709 ,  A61K31/4164 ,  A61K31/205 ,  A61K31/133

Abstract: Provided herein are compositions, systems, and methods for treating a disease, such as kidney and/or cardiovascular disease, with an agent that reduces the production of trimethylamine (TMA) or trimethylamine-n-oxide (TMAO) in a subject. In certain embodiments, the agent is: i) 3,3-dimethyl-1-butanol (DMB) or a DMB derivative or related compound, ii) acetylsalicylic acid or derivative thereof (e.g., with an enteric coating for delivery to the colon and/or cecum); iii) a flavin monooxygenase 3 (FMO3) inhibitor; iv) a gut TMA lyase inhibitor; v) an antibiotic or antimicrobial; vi) a probiotic or prebiotic; vii) an antiplatelet agent; or viii) a TMA and/or TMAO sequestering agent.