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公开(公告)号:US10358636B2
公开(公告)日:2019-07-23
申请号:US15310917
申请日:2015-05-14
Applicant: TRUSTEES OF DARTMOUTH COLLEGE , STEALTH BIOLOGICS, LLC
Inventor: Karl E. Griswold , Chris Bailey-Kellogg , Yoonjoo Choi , Kristina Blazanovic , Hongliang Zhao , Deeptak Verma
IPC: C12N9/52 , A61K31/18 , A61K31/47 , A61K38/00 , A61K38/48 , A61K45/06 , A61K31/397 , A61K31/519 , A61K31/545 , A61K31/7036 , A61K31/7048
Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.
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公开(公告)号:US10349015B2
公开(公告)日:2019-07-09
申请号:US15580808
申请日:2015-12-01
Applicant: TRUSTEES OF DARTMOUTH COLLEGE
Inventor: Eric R. Fossum , Leo Anzagira
IPC: H04N9/04 , H04N5/378 , H01L27/146 , H04N5/3745
Abstract: Some embodiments provide an image sensor color filter array pattern that mitigates and/or minimizes the impact of optical and carrier crosstalk on color reproduction accuracy and/or signal-to-noise, the color filter array comprising a plurality of kernels, wherein each kernel has an identical configuration of color filter elements comprising primary color filter elements corresponding to at least three respective different primary colors, and a plurality of secondary color filter elements. A respective one of the secondary color filter elements is disposed as a nearest neighbor to and between every pair of primary color filter elements of different colors in the kernel, with the respective secondary color filter element representing a secondary color that is a combination of the different colors of the primary color filter elements that are nearest neighbors to the respective secondary color filter element.
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公开(公告)号:US10340305B2
公开(公告)日:2019-07-02
申请号:US15563593
申请日:2016-03-31
Applicant: DARTMOUTH COLLEGE
Inventor: Jiaju Ma , Leo Anzagira , Eric R. Fossum
IPC: H01L27/146 , H04N5/3745 , H04N5/355
Abstract: Some embodiments provide an image sensor pixel comprising a junction field effect transistor (JFET) and a floating diffusion configured to act as the gate of the JFET. An image sensor may comprise a plurality of pixels, at least one pixel comprising a floating diffusion region formed in a semiconductor substrate, a transfer gate configured to selectively cause transfer of photocharge stored in the pixel to the floating diffusion, and a JFET having (i) a source and a drain coupled by a channel region, and (ii) a gate comprising the floating diffusion region.
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公开(公告)号:US20190120863A1
公开(公告)日:2019-04-25
申请号:US16091568
申请日:2017-04-05
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor: Joseph J. BELBRUNO , Ziyi CHAI
Abstract: A device for detecting cotinine includes (a) a film that includes a plurality of molecularly-imprinted-polymer (MIP) coated conductive nanoparticles having specific affinity for binding with cotinine, and (b) two electrodes in contact with the film for passing electrical current through the film to detect binding with cotinine as a change in electrical conductivity of the film. A MIP coated conductive nanoparticle for detecting cotinine includes (a) a conductive nanoparticle, (b) a silicon dioxide coating formed on the conductive nanoparticle and forming a first shell around the conductive nanoparticle, and (c) an MIP coating formed on the silicon dioxide coating and forming the second shell, wherein the MIP coating includes a polymer molecularly imprinted with cotinine to provide specific affinity for binding of cotinine to the MIP coated conductive nanoparticle such that the cotinine is detectable as a change in electrical conductivity of the MIP coated conductive nanoparticle.
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公开(公告)号:US10251387B2
公开(公告)日:2019-04-09
申请号:US15095943
申请日:2016-04-11
Applicant: New Health Sciences, Inc. , Trustees of Dartmouth College
Inventor: Larry J. Dumont , Tatsuro Yoshida
Abstract: The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels.
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公开(公告)号:US20190083592A1
公开(公告)日:2019-03-21
申请号:US16166607
申请日:2018-10-22
Applicant: TRUSTEES OF DARTMOUTH COLLEGE
Inventor: Randolph J. NOELLE , Cory L. AHONEN , Ross M. KEDL
IPC: A61K39/00 , A61K38/08 , A61K31/7115 , A61K31/7084 , A61K31/5377 , A61K39/395 , A61K45/06 , A61K39/39 , A61K38/10 , A61K39/12 , A61K31/4745 , A61K38/16 , A61K39/02 , A61K31/739
Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
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公开(公告)号:US10222438B2
公开(公告)日:2019-03-05
申请号:US14440268
申请日:2013-11-01
Applicant: The Trustees of Dartmouth College
Inventor: John B. Weaver , Alexander Hartov
Abstract: A system for measuring responses of magnetic nanoparticles has static magnetic bias field along first axis, and AC driving coils providing AC magnetic field along second axis perpendicular to the first axis, both fields passing through an imaging zone. Sensing coils are oriented to sense fields parallel to the first axis, but not parallel to the second axis. A processor determines responses of nanoparticles in the imaging zone to the AC field. Another system has DC bias on first axis and AC driving coils providing an AC magnetic field along a second axes, magnetic gradient oriented along the first and/or second axis, and the second axis is rotated mechanically or electronically. The signal processor provides a voxel-based model of magnetic nanoparticle distribution in imaging zone. In some embodiments, the static magnet is a main magnet of a magnetic resonance imaging system.
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公开(公告)号:US20190057806A1
公开(公告)日:2019-02-21
申请号:US16166501
申请日:2018-10-22
Applicant: The Trustees of Dartmouth College
Inventor: Charles R. Sullivan
CPC classification number: H01F27/34 , H01F17/0013 , H01F27/16 , H01F27/24 , H01F27/2804 , H01F2017/0026 , H01F2027/2809 , H01P3/16 , H02J50/12
Abstract: A multilayer conductor includes at least one separation dielectric layer and a plurality of conductor layers stacked in an alternating manner. Each of the plurality of conductor layers includes a first conductor sublayer and a second conductor sublayer separated from the first conductor sublayer by a sublayer dielectric layer. The second conductor sublayer at least partially overlaps with the first conductor sublayer in each of the plurality of conductor layers. The multilayer conductor is included, for example, in a device including a magnetic core adjacent to at least part of the multilayer conductor.
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公开(公告)号:US10147870B2
公开(公告)日:2018-12-04
申请号:US15526713
申请日:2015-11-12
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor: John X. J. Zhang , Dajing Chen
IPC: H01L41/04 , H01L41/047 , H01L41/193 , H01L41/45 , H01L41/09 , H01L41/113 , H01L41/08
Abstract: A method for producing a porous piezoelectric polymer film with a dense surface, includes depositing a polymer solution onto a substrate to form a polymer film including a solvent; evaporating a portion of the solvent to form the dense surface away from the substrate; forming water droplets in interior of the polymer film; and substantially evaporating the water droplets and remaining solvent to form porous interior. A piezoelectric composition includes a piezoelectric material with a porous interior and a dense surface for interfacing with an electrode. A piezoelectric device includes a first electrode; a porous piezoelectric film with a dense surface and porous interior, wherein the porous piezoelectric film is deposited on the first electrode and the dense surface is away from the first electrode; and a second electrode deposited on the dense surface for, together with the first electrode, providing an electrical interface for the porous piezoelectric film.
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公开(公告)号:US10105426B2
公开(公告)日:2018-10-23
申请号:US14850529
申请日:2015-09-10
Applicant: TRUSTEES OF DARTMOUTH COLLEGE
Inventor: Randolph J. Noelle , Cory L. Ahonen , Ross M. Kedl
IPC: A61K39/02 , A61K39/12 , A61K38/19 , A61K39/395 , A61K39/00 , A61K31/4745 , A61K39/39 , A61K45/06 , A61K38/16 , A61K31/5377 , A61K31/7084 , A61K31/7115 , A61K31/739 , A61K38/08 , A61K38/10
Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
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