利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.017 秒)

    System and apparatus for porously-encapsulated magnetic-nanoparticle biosensors
    1.
    发明授权
    System and apparatus for porously-encapsulated magnetic-nanoparticle biosensors 有权

    公开(公告)号：US11262355B2

    公开(公告)日：2022-03-01

    申请号：US16708302

    申请日：2019-12-09

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

    发明人： John B. Weaver ,  Barjor Gimi ,  Karl Griswold

    IPC分类号： G01N33/543 ,  G01N27/74 ,  G01R33/12 ,  A61B5/055

    摘要： A system for measuring analyte concentrations has porous-walled nanocontainers containing multiple magnetic nanoparticles, the magnetic nanoparticles coated with a selective binder that is analyte-responsive and binds a the analyte, an indicator substance releasable from the selective binder by the analyte, or an indicator substance cleavable by the analyte, apparatus for exposing the nanocontainers to a fluid potentially containing the analyte, and magnetic spectroscopy of Brownian motion sensing apparatus for detecting agglutination of the nanoparticles or binding of analyte to the nanoparticles. The system is used in a method comprising coating magnetic nanoparticles with a selective binder, encapsulating the magnetic nanoparticles in porous nanocontainers, exposing the nanocontainers to a fluid potentially containing analyte, using magnetic spectroscopy of Brownian motion sensing apparatus to detect agglutination or binding of the nanoparticles, and translating Brownian motion spectra to analyte concentrations.

    System And Apparatus For Combined Magnetic Resonance Imaging With Magnetic Spectroscopy of Brownian Motion And/Or Magnetic Nanoparticle Imaging
    2.
    发明申请
    System And Apparatus For Combined Magnetic Resonance Imaging With Magnetic Spectroscopy of Brownian Motion And/Or Magnetic Nanoparticle Imaging 审中-公开
    用于具有布朗运动和/或磁纳米颗粒成像的磁光谱的组合磁共振成像的系统和装置

    公开(公告)号：US20150276902A1

    公开(公告)日：2015-10-01

    申请号：US14440268

    申请日：2013-11-01

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

    发明人： John B. Weaver ,  Alexander Hartov

    IPC分类号： G01R33/54 ,  G01R33/36

    CPC分类号： G01R33/4808 ,  G01R33/1276

    摘要： A system for measuring responses of magnetic nanoparticles has static magnetic bias field along first axis, and AC driving coils providing AC magnetic field along second axis perpendicular to the first axis, both fields passing through an imaging zone. Sensing coils are oriented to sense fields parallel to the first axis, but not parallel to the second axis. A processor determines responses of nanoparticles in the imaging zone to the AC field. Another system has DC bias on first axis and AC driving coils providing an AC magnetic field along a second axes, magnetic gradient oriented along the first and/or second axis, and the second axis is rotated mechanically or electronically. The signal processor provides a voxel-based model of magnetic nanoparticle distribution in imaging zone. In some embodiments, the static magnet is a main magnet of a magnetic resonance imaging system.

    摘要翻译： 用于测量磁性纳米颗粒的响应的系统具有沿着第一轴的静态磁偏置场，并且AC驱动线圈沿着垂直于第一轴的第二轴提供交流磁场，两个场都通过成像区。 感测线圈被定向成感测平行于第一轴线但不平行于第二轴线的场。 处理器确定成像区域中的纳米颗粒对AC场的响应。 另一个系统在第一轴上具有DC偏置，并且AC驱动线圈沿着第二轴线提供交流磁场，沿着第一和/或第二轴线定向的磁梯度，并且第二轴线被机械地或电子地旋转。 信号处理器在成像区域中提供基于体素的磁性纳米粒子分布模型。 在一些实施例中，静磁体是磁共振成像系统的主磁体。

    System and method to measure pain levels of patients following surgery
    4.
    发明授权
    System and method to measure pain levels of patients following surgery 有权

    公开(公告)号：US11617536B1

    公开(公告)日：2023-04-04

    申请号：US16779556

    申请日：2020-01-31

    申请人： Dartmouth-Hitchcock Clinic ,  The Trustees of Dartmouth College

    发明人： Sohail K. Mirza ,  John B. Weaver

    IPC分类号： A61B5/00 ,  A61K9/14 ,  A61B5/01

    摘要： This invention provides a non-invasive system for measuring pain level in a body at a site containing a predetermined concentration of magnetic nanoparticles. A drive coil and a pickup coil transmit and measure a field passing through the site based upon response of the magnetic nanoparticles, and a processor computes a pain level based upon variations in the field. The pain level can be indexed to an absolute scale that affords more predictability and objectivity in determining true pain level. Illustratively, the processor derives values for levels of cytokine IL-6, SP and temperature at the site, which are translated into the pain level. In an embodiment, the system and method can be implemented in a handheld device in which the drive coil and pickup coil reside in a housing.

    System And Apparatus For Porously-Encapsulated Magnetic-Nanoparticle Biosensors
    5.
    发明申请
    System And Apparatus For Porously-Encapsulated Magnetic-Nanoparticle Biosensors 审中-公开
    用于包封磁纳米颗粒生物传感器的系统和装置

    公开(公告)号：US20150148661A1

    公开(公告)日：2015-05-28

    申请号：US14408041

    申请日：2013-06-14

    申请人： The Trustees of Dartmouth College

    发明人： John B. Weaver ,  Barjor Gimi ,  Karl Griswold

    IPC分类号： G01N33/543 ,  G01N27/74 ,  A61B5/055

    CPC分类号： G01N33/54366 ,  A61B5/055 ,  G01N27/745 ,  G01N33/54326 ,  G01R33/1269

    摘要： A system for measuring analyte concentrations has porous-walled nanocontainers containing multiple magnetic nanoparticles, the magnetic nanoparticles coated with a selective binder that is analyte-responsive and binds a the analyte, an indicator substance releasable from the selective binder by the analyte, or an indicator substance cleavable by the analyte, apparatus for exposing the nanocontainers to a fluid potentially containing the analyte, and magnetic spectroscopy of Brownian motion sensing apparatus for detecting agglutination of the nanoparticles or binding of analyte to the nanoparticles. The system is used in a method comprising coating magnetic nanoparticles with a selective binder, encapsulating the magnetic nanoparticles in porous nanocontainers, exposing the nanocontainers to a fluid potentially containing analyte, using magnetic spectroscopy of Brownian motion sensing apparatus to detect agglutination or binding of the nanoparticles, and translating Brownian motion spectra to analyte concentrations.

    摘要翻译： 用于测量分析物浓度的系统具有包含多个磁性纳米颗粒的多孔壁纳米容器，所述磁性纳米粒子涂覆有选择性粘合剂，所述选择性粘合剂是分析物响应性的并且结合分析物，可由分析物从选择性粘合剂释放的指示剂物质，或指示剂 被分析物可分离的物质，用于将纳米容器暴露于潜在含有分析物的流体的装置，以及用于检测纳米颗粒的凝集或者将分析物结合到纳米颗粒的布朗运动检测装置的磁光谱。 该系统用于包括用选择性粘合剂涂覆磁性纳米颗粒的方法，将磁性纳米颗粒包封在多孔纳米容器中，使用布朗运动感测装置的磁光谱法将纳米容器暴露于潜在含有分析物的流体中，以检测纳米颗粒的凝集或结合 ，并将布朗运动光谱转换为分析物浓度。

    System and apparatus for combined magnetic resonance imaging with magnetic spectroscopy of brownian motion and/or magnetic nanoparticle imaging
    6.
    发明授权
    System and apparatus for combined magnetic resonance imaging with magnetic spectroscopy of brownian motion and/or magnetic nanoparticle imaging 有权

    公开(公告)号：US10222438B2

    公开(公告)日：2019-03-05

    申请号：US14440268

    申请日：2013-11-01

    申请人： The Trustees of Dartmouth College

    发明人： John B. Weaver ,  Alexander Hartov

    IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/12

    摘要： A system for measuring responses of magnetic nanoparticles has static magnetic bias field along first axis, and AC driving coils providing AC magnetic field along second axis perpendicular to the first axis, both fields passing through an imaging zone. Sensing coils are oriented to sense fields parallel to the first axis, but not parallel to the second axis. A processor determines responses of nanoparticles in the imaging zone to the AC field. Another system has DC bias on first axis and AC driving coils providing an AC magnetic field along a second axes, magnetic gradient oriented along the first and/or second axis, and the second axis is rotated mechanically or electronically. The signal processor provides a voxel-based model of magnetic nanoparticle distribution in imaging zone. In some embodiments, the static magnet is a main magnet of a magnetic resonance imaging system.