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91.
公开(公告)号:US10886963B2
公开(公告)日:2021-01-05
申请号:US16453461
申请日:2019-06-26
Applicant: The Trustees of Princeton University
Inventor: Kaushik Sengupta , Xue Wu , Chandrakanth Chappidi , Xuyang Lu
Abstract: Embodiments generally disclosed herein relate to a sub-wavelength multi-port codesign approach between the unit transceiver element and the integrated EM interface to enable a generalized broadband MIMO array with individually programmable element patterns. The co-design approach allows processing of radiated signals at the antenna level distinct from classical arrays. The transmitter and receiver architectures with the integrated EM interface are implemented in 65-nm CMOS and have a bandwidth of 37-73 GHz. Wireless links with data rates up to 12 Gb/s are demonstrated across the spectrum with a wide range of reconfigurability of the active EM interface. The multifunctional EM interface and the broadband transceivers can enable future efficient and compact MIMO arrays for reliable links exploiting frequency, spatial, pattern and polarization diversities.
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公开(公告)号:US10862073B2
公开(公告)日:2020-12-08
申请号:US14018449
申请日:2013-09-05
Inventor: Prashant Mandlik , Ruiqing Ma , Sigurd Wagner , Bhadrinarayana Lalgudi Visweswaran
Abstract: Methods for forming a coating over a surface are disclosed. A method includes directing a first source of barrier film material toward a substrate in a first direction at an angle θ relative to the substrate, wherein θ is greater than about 0° and less than about 85°. Additionally, a method of depositing a barrier film over a substrate includes directing a plurality of N sources of barrier film material toward a substrate, each source being directed at an angle θN relative to the substrate, wherein for each θN, θ is greater than about 0° and less than about 180°. For at least a first of the θN, θN is greater than about 0° and less than about 85°, and for at least a second of the θN, θN is greater than about 95° and less than about 180°.
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公开(公告)号:US10786545B2
公开(公告)日:2020-09-29
申请号:US16406837
申请日:2019-05-08
Inventor: Yibin Kang , Yongna Xing , Liling Wan , Feng Guo
Abstract: The present disclosure related in general to methods of treating cancer by interfering with the interaction of metadherin with Staphylococcal nuclease domain-containing 1 (SND1) using peptides or other compounds that inhibit the binding of SND1 with metadherin and inhibit the activity of the MTDH-SND1 complex in tumor cells.
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公开(公告)号:US20200291075A1
公开(公告)日:2020-09-17
申请号:US16889690
申请日:2020-06-01
Applicant: The Trustees of Princeton University
Inventor: Jared Toettcher , Jose Avalos , Maxwell Wilson , Alexander Goglia , Evan M. Zhao , Agnieszka Gil , Cesar Carrasco-Lopez
IPC: C07K14/415 , C07K1/16 , C07K1/36 , C07K19/00
Abstract: Provided herein is an isolated fusion protein comprising a light-responsive domain and a heterologous peptide component. Exposure of the fusion protein to light induces a conformational change in the fusion protein that alters an activity of the fusion protein and the activity is a binding activity selected from an in vitro binding activity, an in vivo extracellular binding activity and an in vivo intracellular binding activity. Also provided are methods of using and identifying the fusion proteins.
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公开(公告)号:US10772862B2
公开(公告)日:2020-09-15
申请号:US16160237
申请日:2018-10-15
Inventor: Joshua Rabinowitz , Jurre Kamphorst , Craig Thompson , Justin Cross
IPC: A61K31/20 , A61K45/06 , A61K31/202 , G01N33/574 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/17 , A61K31/685 , A61K31/66 , A61K36/889
Abstract: Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
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公开(公告)号:US20200277211A1
公开(公告)日:2020-09-03
申请号:US16651737
申请日:2018-09-25
Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
Inventor: Peter R. JAFFE , Shan HUANG
Abstract: In one aspect, oxidant is employed for enhancing Feammox activity. Briefly, a medium comprises an ammonium containing contaminant, an iron component, an oxidant, and a Feammox bacterium and/or enzyme thereof capable of oxidizing ammonium with reduction of Fe(II) to Fe(III), wherein the oxidant regenerates Fe(III) via Fe(II) oxidation. In some embodiments, the medium is soil and/or water.
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公开(公告)号:US20200237725A1
公开(公告)日:2020-07-30
申请号:US16842513
申请日:2020-04-07
Applicant: The Trustees of Princeton University
Inventor: Joshua D. Rabinowitz , Hahn Kim , Gregory S. Ducker , Jonathan M. Ghergurovich
IPC: A61K31/4162 , A61K45/06 , A61K31/19 , A61P35/00 , A61P37/00 , A61K31/519
Abstract: The disclosure provides compounds. In certain embodiments, compounds of the disclosure are capable of inhibiting a mammalian SHMT, such as human SMHT1 and/or SHMT2. Compounds of the disclosure have numerous uses.
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公开(公告)号:US10722719B2
公开(公告)日:2020-07-28
申请号:US15552180
申请日:2016-02-12
Inventor: Younghyun Kim , Woo Suk Lee , Vijay Raghunathan , Niraj K. Jha , Anand Raghunathan
Abstract: According to some embodiments, a system for securing communications between an implantable wearable medical device (IWMD) and an external device (ED) is disclosed. The system includes a wireless radio frequency (RF) channel configured for communication between the IWMD and the ED. The system further includes a vibration-based side channel configured for verifying communication between the IWMD and the ED such that the RF channel is activated only when the IWMD detects a vibration signal generated by an ED.
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公开(公告)号:US20200183050A1
公开(公告)日:2020-06-11
申请号:US16623378
申请日:2018-06-19
Inventor: Zin LIN , Federico CAPASSO , Alejandro W. RODRIGUEZ , Marko LONCAR , Benedikt GROEVER
Abstract: A multi-layered lens comprises a plurality of metasurface layers. At least some layers of the plurality of metasurface layers include features that exhibit angular phase controls. The angular phases of the at least some layers cause an angular aberration correction or an angle convergence that focuses light onto a focal point regardless of angles of incidence.
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公开(公告)号:US10675138B2
公开(公告)日:2020-06-09
申请号:US14875168
申请日:2015-10-05
Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
Inventor: Jeffrey Schwartz , Jean E. Schwarzbauer , Casey M. Jones , Patrick E. Donnelly , Stephen B. Bandini , Shivani Singh
IPC: A61L27/36 , A61F2/00 , G03F7/40 , A61L27/16 , A61L27/22 , A61L27/24 , A61L27/10 , A61L27/06 , A61L27/30 , C12N5/00 , G01N33/50 , A61L27/38 , A61L27/02 , A61L27/04 , A61F2/30
Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair and transplantation.
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