公开(公告)号：US12008073B2

公开(公告)日：2024-06-11

申请号：US17293638

申请日：2019-11-07

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Dong Hyun Yang ,  June Goo Lee ,  Young-Hak Kim

IPC: G06F18/214 ,  A61B6/00 ,  A61B6/03 ,  G06F18/21 ,  G06N3/04

CPC classification number: G06F18/214 ,  G06F18/2163 ,  G06N3/04 ,  A61B6/032 ,  A61B6/5217 ,  G06V2201/03

Abstract: A myocardium image analysis method comprising acquiring a target image including precontrast-enhanced myocardium, based on a type of coronary artery related to the myocardium, distinguishing the myocardium included in the target image, using an artificial neural network, providing information on the distinguished myocardium, wherein the artificial neural network is trained based on a training database generated by matching images for training of precontrast-enhanced coronary artery and myocardium and images for training of postcontrast-enhanced coronary artery and myocardium.

公开(公告)号：US20240168028A1

公开(公告)日：2024-05-23

申请号：US18557802

申请日：2022-04-28

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Sang Yeob KIM ,  Sang We KIM

IPC: G01N33/574 ,  G01N33/68 ,  G16H20/10

CPC classification number: G01N33/57484 ,  G01N33/6854 ,  G16H20/10 ,  G01N2474/20 ,  G01N2800/52

Abstract: The present disclosure relates to a method of providing information for predicting a treatment response to an immune checkpoint inhibitor in a cancer patient by using multiplex immunohistochemistry, wherein, by performing multiplex immunohistochemistry on tumor tissue of a cancer patient to measure an expression level of an immune checkpoint molecule by an automated method, the treatment response to the immune checkpoint inhibitor in the cancer patient can be accurately and quickly predicted. In addition, unlike existing methods using single immunohistochemistry, the disclosed method can reduce errors of an inspector by analyzing markers simultaneously expressed in a single cell and evaluating the same by an automated method, and thus will be widely used as a companion diagnostic method for an immune checkpoint inhibitor.

公开(公告)号：US20240013907A1

公开(公告)日：2024-01-11

申请号：US18251671

申请日：2021-09-30

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Jae Soon CHOI ,  Young Hak KIM ,  Youngjin MOON

IPC: G16H40/63

CPC classification number: G16H40/63

Abstract: A surgical tool control apparatus according to an embodiment comprises: a housing; and a control assembly including a frame connected to the housing, and a first roller module, a second roller module, and a third roller module which are installed on the frame, wherein the second roller module can horizontally move toward the first roller module so that a first surgical tool can be held between the first roller module and the second roller module, and can horizontally move toward the third roller module so that a second surgical tool can be held between the second roller module and the third roller module.

公开(公告)号：US11842493B2

公开(公告)日：2023-12-12

申请号：US16938773

申请日：2020-07-24

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Dong Wha Kang ,  Young Hwan Kim

IPC: G06T7/00 ,  G16H20/17 ,  G16H50/50 ,  G16H50/30 ,  G16H50/20 ,  G16H30/40 ,  A61B5/00 ,  A61B5/02 ,  A61B5/026 ,  G06N7/01

CPC classification number: G06T7/0016 ,  A61B5/0042 ,  A61B5/02042 ,  A61B5/0263 ,  A61B5/4842 ,  A61B5/7275 ,  G06N7/01 ,  G16H20/17 ,  G16H30/40 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  A61B2576/026 ,  G06T2207/10088 ,  G06T2207/20076 ,  G06T2207/30016

Abstract: A method for predicting brain disease state change is disclosed. The method includes acquiring test images obtained by capturing a portion of a human brain at a time interval, performing a pre-processing procedure of converting the test images into test voxels configured to be processed for image analysis, wherein a respective test voxel of the test voxels is composed of three-dimensional voxel units, mapping first and second test voxels selected from the test voxels acquired from a patient, with each other on a three-dimensional voxel unit, wherein the first test voxel is acquired at a first time-point and the second test voxel is acquired at a second time-point, generating a voxel-based data-set based on the mapped first and second test voxels, extracting a change in the test voxels using a deep neural network, and generating a state change probability model based on the change in the test voxels.

公开(公告)号：US20230365626A1

公开(公告)日：2023-11-16

申请号：US18325582

申请日：2023-05-30

Applicant: Industry Academy Cooperation Foundation of Sejong University ,  University of Ulsan Foundation for Industry Cooperation ,  The Asan Foundation

Inventor： Yang-Hee KIM ,  Ki Ryeong KIM ,  Dongyeol LIM ,  Hyung Wook KIM ,  Jae-Young KOH

IPC: C07K7/08 ,  A61P25/28

CPC classification number: C07K7/08 ,  A61P25/28 ,  A61K38/00

Abstract: The present disclosure provides a method for treating a degenerative neuronal disease, comprising administering, to an individual suffering from neurodegenerative disease, a therapeutically effective amount of an alloferon peptide having an amino acid sequence of SEQ ID NO: 1.

公开(公告)号：US11653636B2

公开(公告)日：2023-05-23

申请号：US16686024

申请日：2019-11-15

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  THE ASAN FOUNDATION

Inventor： Joo Yong Lee ,  In Jeoung Baek ,  Young Hoon Sung

IPC: C12N15/00 ,  A01K67/027 ,  G01N33/00 ,  A61K49/00 ,  C12N15/85

CPC classification number: A01K67/0276 ,  A61K49/0008 ,  C12N15/8509 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  C12N2015/8536

Abstract: The present invention relates to a Pde6b-deficient animal model of retinal degeneration produced by engineered endonucleases, and a method for producing the same. In the animal model of retinal degeneration according to the present invention, only a specific target gene can be removed using engineered endonucleases, so that mutagenesis can be stably achieved. In addition, it is possible to produce a congenital animal model through genetic manipulation at the embryonic stage rather than through acquired factors, which allows for production of an animal model that uniformly exhibits symptoms of the disease in question without being influenced by other factors.

公开(公告)号：US20230142546A1

公开(公告)日：2023-05-11

申请号：US17995054

申请日：2021-03-24

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPER

Inventor： Sang Ju LEE ,  Seung Jun OH ,  Jae-Seung KIM ,  Dae Hyuk MOON ,  Sun Young CHAE

IPC: A61K51/04 ,  A61P7/02

CPC classification number: A61K51/0497 ,  A61P7/02

Abstract: A compound represented by the following Formula 1 or a pharmaceutically acceptable salt thereof:




where R1 is a chelating agent labeled with a metallic radioisotope. A thrombus imaging composition including the compound or the pharmaceutically acceptable salt thereof labeled with a metallic radioisotope as an active ingredient.

公开(公告)号：US20230129721A1

公开(公告)日：2023-04-27

申请号：US17995024

申请日：2021-01-19

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Sang Ju LEE ,  Seung Jun OH ,  Dae Hyuk MOON ,  Jin-Sook RYU ,  Jae-Seung KIM ,  Minyung OH ,  Yong-il KIM ,  Jong Jin LEE ,  Sun Young CHAE ,  Dong Yun LEE

IPC: A61K51/04 ,  A61K47/22 ,  A61K47/24 ,  A61K47/20

Abstract: The present invention relates to: a composition for stabilizing a radiopharmaceutical, the composition comprising a vitamin B compound as an active component; and a radiopharmaceutical composition comprising the same. Due to the inclusion of the vitamin B compound, it is possible to stabilize the radiochemical purity of the radioactive compound by inhibiting the radioactive degradation thereof at room temperature as well as at high temperature.

公开(公告)号：US20230084335A1

公开(公告)日：2023-03-16

申请号：US17904678

申请日：2021-02-08

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  CBSBIOSCIENCE CO., LTD

Inventor： Chang-Sik YU ,  In-Ja PARK ,  Seung-Mo HONG ,  Sung-Min AHN ,  Adnan Ahmad ANSARI ,  Bilal MUSTAFA ,  Jin-Young PARK

IPC: C12Q1/6886

Abstract: Provided are an analytical method of providing an information for diagnosis of a patient who exhibits a response to preoperative chemoradiotherapy in a rectal cancer patient, wherein the expression levels of nine genes, i.e., FGFR3, GNA11, H3F3A, IL12A, IL1R1, IL2RB, NKD1, SGK2, and SPRY2 genes, is analyzed in combination, in carcinoma tissues of a rectal cancer patient, the response (susceptibility) to preoperative chemoradiotherapy can be predicted with high accuracy, and therefore the combination of said genes can be usefully applied as a biomarker for selecting a rectal cancer patient who exhibits a response to preoperative chemoradiotherapy.

公开(公告)号：US20230077745A1

公开(公告)日：2023-03-16

申请号：US18056766

申请日：2022-11-18

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Young Seok KIM ,  In Ha YUN

IPC: A61M3/02

Abstract: Disclosed is a rectum expanding balloon catheter. The rectum expanding balloon catheter includes a catheter body having a rectum insertion part inserted into a rectum and a gripping part extending from the rectum insertion part in a lengthwise direction thereof and that is used to insert the rectum insertion part into the rectum, and in which a fluid flow passage, along which a fluid flows, is formed in an interior thereof, a balloon that expands and contracts an area on an outside of the rectum insertion part and that locates the rectum insertion part in the rectum, and a stopper provided in the catheter body, and that restricts a length, by which the catheter body is inserted into the rectum, while being adhered to a periphery of an anal passage.