公开(公告)号：US20190112618A1

公开(公告)日：2019-04-18

申请号：US15748939

申请日：2016-07-29

Applicant: UWM Research Foundation, Inc.

Inventor： Dazhong Zhao ,  Jian Huang

IPC: C12N15/82 ,  C12N15/113

Abstract: Disclosed herein are compositions and methods for creating sterile plants by genetically ablating microspore and megaspore mother cells. Also disclosed herein are methods of restoring fertility of sterile male and female plants.

公开(公告)号：US20180362500A1

公开(公告)日：2018-12-20

申请号：US16116663

申请日：2018-08-29

Applicant: UWM Research Foundation, Inc. ,  Women and Infants Hospital of Rhode Island

Inventor： Alexander E. Arnold ,  Preetpal Singh Sidhu ,  Premchendar Nandhikonda ,  Rakesh K. Singh

IPC: C07D401/12 ,  C07D407/12 ,  A61K45/06 ,  C07D209/16 ,  A61K31/404 ,  C07D209/10 ,  C07D209/14

Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.

公开(公告)号：US10003214B2

公开(公告)日：2018-06-19

申请号：US15076403

申请日：2016-03-21

Applicant: General Electric Company ,  UWM Research Foundation, Inc.

Inventor： Adel Nasiri ,  Seyed Ahmad Hamidi ,  Russell Wayne Hum ,  John Ferdinand Bopp

IPC: H02J3/00 ,  H02J9/06 ,  H02J7/00

CPC classification number: H02J9/061 ,  H02J7/0014 ,  H02J7/0021 ,  H02J7/0065

Abstract: A battery management system for monitoring battery cells of an uninterruptible power supply (UPS) coupled to a medical imaging load. The battery management system includes a first slave configured to obtain an operating parameter of a first battery cell. The first slave is configured to determine health of the first battery cell based at least in part on the operating parameter. The first slave is configured to generate a signal indicating the health of the first battery cell to communicate serially, via at least a second slave, to a master.

公开(公告)号：US20180134698A1

公开(公告)日：2018-05-17

申请号：US15578790

申请日：2016-06-03

Applicant: UWM Research Foundation, Inc. ,  Medical University of Vienna ,  National Taiwan University ,  University of Belgrade - Faculty of Pharmacy

Inventor： Lih-Chu Chiou ,  James Cook ,  Margot Ernst ,  Pi-Chuan Fan ,  Daniel Knutson ,  Matheus Meirelles ,  Marko Mihovilovic ,  Werner Sieghart ,  Zdravko Varagic ,  Ranjit Verma ,  Laurin Wimmer ,  Christopher Witzigmann ,  David Chan Bodin Siebert ,  Miroslav M. Savic

IPC: C07D471/04 ,  C07D471/14 ,  A61P25/18 ,  A61P25/24 ,  A61P25/06 ,  A61P27/16

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61P25/06 ,  A61P25/18 ,  A61P25/24 ,  A61P27/16 ,  C07D471/14 ,  C07D491/147 ,  C07D495/14 ,  C07D498/14

Abstract: Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis;depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.

公开(公告)号：US20170007257A1

公开(公告)日：2017-01-12

申请号：US15204701

申请日：2016-07-07

Applicant: UWM Research Foundation, Inc.

Inventor： Charles Potter ,  Ilya Avdeev ,  Maxwell Potter ,  Alex Francis

IPC: A61B17/122

CPC classification number: A61B17/122 ,  A61B2017/2911 ,  A61B2090/037

Abstract: A clamping device for an umbilical cord includes a first member having a first clamping surface and a second member having a second clamping surface. The second member is flexibly coupled to the first member. The clamping device further includes an arcuate body extending away from the first member to assist an operator in moving the first member relative to the second member. The arcuate body is removably coupled to the first member.

Abstract translation: 用于脐带的夹紧装置包括具有第一夹紧表面的第一构件和具有第二夹紧表面的第二构件。 第二构件柔性地联接到第一构件。 夹持装置还包括弓形主体，其远离第一构件延伸，以帮助操作者相对于第二构件移动第一构件。 弓形主体可拆卸地联接到第一构件。

公开(公告)号：US09133141B2

公开(公告)日：2015-09-15

申请号：US14148959

申请日：2014-01-07

Applicant: Marquette University ,  UWM Research Foundation, Inc.

Inventor： James M. Cook ,  David A. Baker ,  Edward Merle Johnson, II ,  Wenyuan Yin ,  Ranjit Singh Verma

IPC: C07D271/06 ,  C07D249/08 ,  C07D413/12 ,  C07K5/062 ,  C07K5/103

CPC classification number: C07D271/06 ,  C07D249/08 ,  C07D413/12 ,  C07K5/0606 ,  C07K5/1008

Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸生物电子等排体。 本发明还包括含有这种生物电子等排体的药物组合物和使用生物电子等离子体治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US20150175559A1

公开(公告)日：2015-06-25

申请号：US14627379

申请日：2015-02-20

Applicant: Marquette University ,  UWM Research Foundation, Inc.

Inventor： James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward M. Johnson, II

IPC: C07D241/08 ,  C07D487/04 ,  A61K9/00 ,  C07D211/86

CPC classification number: C07D241/08 ,  A61K9/0053 ,  C07C323/60 ,  C07C327/34 ,  C07D211/86 ,  C07D487/04 ,  C07K5/0606

Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimmers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimmers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimmers, analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明公开了具有以下通式的半胱氨酸前药：具有以下通式的半胱氨酸前药的胱氨酸二聚体：具有以下通式的受保护半胱氨酸类似物：具有以下通式的受保护的半胱氨酸类似物的二聚体：本发明还包括含有 公开了前药，二聚体，类似物和使用这些化合物治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US20140354282A1

公开(公告)日：2014-12-04

申请号：US14358938

申请日：2012-11-14

Applicant: UWM Research Foundation, Inc.

Inventor： Todd P. Kusik ,  Brian S. R. Armstrong ,  Robert T. Barrows

IPC: G01R33/28 ,  H04N5/225 ,  H04N5/232

CPC classification number: G01R33/283 ,  G01R33/5673 ,  H04N5/2254 ,  H04N5/2256 ,  H04N5/23241

Abstract: A camera assembly for use in a MRI machine. The camera assembly includes a Faraday cage defining a shielded cavity and an optical path mount constructed of a highly stiff, dense, and non-electrically-conductive material in the shielded cavity. The camera imager and lens are mounted to the optical path mount. The camera assembly includes a capacitor-based power regulation circuit. The optical path mount is not subject to eddy currents because it is non-electrically-conductive. The capacitor-based power regulation circuit includes very little ferrous material and is within the shielded cavity, to reduce eddy currents. The resulting camera assembly reduces vibrations and shaking in the magnetic field environment of the MRI machine.

Abstract translation: 用于MRI机器的相机组件。 相机组件包括限定屏蔽空腔的法拉第笼，以及由屏蔽腔中的高刚性，致密和非导电材料构成的光路安装座。 相机成像器和镜头安装到光路安装座。 相机组件包括基于电容器的功率调节电路。 光路安装不受涡流的影响，因为它是非导电的。 基于电容器的功率调节电路包括非常少的铁质材料，并且在屏蔽腔内，以减少涡流。 所得到的相机组件减少MRI机器的磁场环境中的振动和振动。

公开(公告)号：US08888074B2

公开(公告)日：2014-11-18

申请号：US13654977

申请日：2012-10-18

Applicant: UWM Research Foundation, Inc.

Inventor： Ryoichi Samuel Amano ,  Ammar Alkhalidi

IPC: B01F3/04

CPC classification number: B01F3/04269 ,  B01F2003/04312 ,  B01F2003/04361 ,  B01F2003/04368

Abstract: A membrane for use in an air diffuser. The membrane includes a nub with a perforation. The nub and perforation and arranged and sized to create smaller bubbles of gas in a liquid column above the membrane.

Abstract translation: 用于空气扩散器的膜。 膜包括具有穿孔的结节。 螺纹和穿孔，并布置和定尺寸以在膜上方的液体柱中产生较小气体气泡。

公开(公告)号：US20130092846A1

公开(公告)日：2013-04-18

申请号：US13655262

申请日：2012-10-18

Applicant: UWM RESEARCH FOUNDATION, INC.

Inventor： Paul Henning ,  Peter Geissinger ,  Steven Kopitzke ,  John Frost

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N2021/6434 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/0221

Abstract: Described herein are apparatuses for detecting an analyte in a liquid sample using optical time of flight spectroscopy. A handheld apparatus for remote real-time detection of Zn2+ in aqueous environments and methods for making and using the apparatus are also described herein.

Abstract translation: 这里描述的是使用光学飞行时间光谱法检测液体样品中的分析物的装置。 本文还描述了用于在水性环境中远程实时检测Zn2 +的手持设备以及用于制造和使用该设备的方法。