公开(公告)号：US07699791B2

公开(公告)日：2010-04-20

申请号：US10363509

申请日：2002-06-12

Applicant: Don Alden ,  Dominique M. Freeman ,  Paul Lum ,  Vladimir Drbal ,  Dirk Boecker ,  Edward D. Verdonk

Inventor： Don Alden ,  Dominique M. Freeman ,  Paul Lum ,  Vladimir Drbal ,  Dirk Boecker ,  Edward D. Verdonk

IPC: A61B5/00

CPC classification number: A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150427 ,  A61B5/150503

Abstract: Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.

Abstract translation: 可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。 该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是微型化和/或一次性的。

公开(公告)号：US07648469B2

公开(公告)日：2010-01-19

申请号：US12023615

申请日：2008-01-31

Applicant: Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

Inventor： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

IPC: A61B5/00 ,  A61B10/00 ,  B65D81/00 ,  A61B17/14 ,  A61B17/32

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detecting member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 μL of the fluid.

Abstract translation: 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 分析物检测构件定位成从由穿透构件产生的伤口接收流体。 检测构件被配置为使用小于1μl流体的样品来确定流体中分析物的浓度。

公开(公告)号：US07547287B2

公开(公告)日：2009-06-16

申请号：US10335212

申请日：2002-12-31

Applicant: Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

Inventor： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.

公开(公告)号：US20080214956A1

公开(公告)日：2008-09-04

申请号：US11972028

申请日：2008-01-10

Applicant: Barry Dean Briggs ,  Dominique Freeman ,  Don Alden ,  Dirk Boecker

Inventor： Barry Dean Briggs ,  Dominique Freeman ,  Don Alden ,  Dirk Boecker

IPC: A61B5/157 ,  A61B5/155

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150832 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/150954 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B17/32093 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet and a processor coupled to the drive force generator capable of changing the direction and magnitude of force exerted on the lancet during the lancing cycle. The driver further includes a human interface on the housing providing at least one output for communicating with the patient.

Abstract translation: 提供了一种刺血针驱动器，其中驾驶员在穿刺周期期间在柳叶刀上施加驱动力并且在组织部位上使用。 驱动器包括用于使柳叶刀前进的驱动力发生器和与驱动力发生器耦合的处理器，其能够改变在穿刺周期期间施加在刺血针上的力的方向和大小。 驱动器还包括在壳体上的人机接口，提供至少一个用于与患者通信的输出。

公开(公告)号：US20080210574A1

公开(公告)日：2008-09-04

申请号：US12055973

申请日：2008-03-26

Applicant: Dirk Boecker

Inventor： Dirk Boecker

IPC: G01N27/26

CPC classification number: A61B5/14532 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/151 ,  A61B5/157 ,  C12Q1/006 ,  G01N27/3273

Abstract: A disposable biosensor test strip is provided that includes a plurality of penetrating members. Each penetrating member is associated with a capillary chamber that has a depth suitable for capillary flow of blood and holds a volume of less than about 1.0 μl of the blood sample. A working electrode and a counter or reference electrode are disposed within the capillary chamber. A reagent is proximal to or in contact with at least the working electrode. The reagent includes an enzyme and a mediator. The reagent reacts with glucose to produce an electroactive reaction product. A blood sample, containing glucose, is applied into the capillary chamber. The capillary chamber directs capillary flow of the blood sample into contact with the reagent to cause the blood sample to at least partially solubilize or hydrate the reagent. The blood sample is detected in the capillary chamber. The electroactive reaction product is electro-oxidized or electro-reduced at the working electrode. Within 10 seconds after detecting, a determination is made of glucose concentration and a readout of the measurement is provided. The glucose determination is made by correlating the electro-oxidized or electro-reduced electroactive reaction product to the concentration of glucose in the blood sample.

Abstract translation: 提供了包括多个穿透构件的一次性生物传感器测试条。 每个穿透构件与毛细管腔室相关联，所述毛细管腔室具有适于血液毛细管流动的深度并保持小于约1.0毫升的血液样品的体积。 工作电极和计数器或参比电极设置在毛细管腔内。 试剂与至少工作电极接近或接触。 试剂包括酶和介体。 试剂与葡萄糖反应产生电活性反应产物。 将含有葡萄糖的血液样品施加到毛细管腔中。 毛细管腔引导血液样品的毛细管流动与试剂接触，使血液样品至少部分溶解或水合试剂。 在毛细血管腔中检测血样。 电活性反应产物在工作电极处被电氧化或电还原。 在检测后10秒钟内，确定葡萄糖浓度，并提供测量的读数。 通过将电氧化或电还原的电活性反应产物与血液样品中的葡萄糖浓度相关联来进行葡萄糖测定。

公开(公告)号：US07410468B2

公开(公告)日：2008-08-12

申请号：US10335182

申请日：2002-12-31

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00 ,  A61B10/00 ,  A61B17/14 ,  A61B17/32 ,  A61M1/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A skin penetrating system includes a housing member and a penetrating member positioned in the housing member. An analyte detecting member is coupled to a sample chamber. The analyte detecting member is configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μL of a body fluid disposed in the sample chamber. A tip of the penetrating member is configured to extend through an opening of the sample chamber.

Abstract translation: 皮肤穿透系统包括壳体构件和定位在壳体构件中的穿透构件。 分析物检测部件耦合到样品室。 分析物检测构件被配置为使用设置在样品室中的小于1μl体液的样品来确定体液中的分析物的浓度。 穿透构件的尖端构造成延伸穿过样品室的开口。

公开(公告)号：US07374544B2

公开(公告)日：2008-05-20

申请号：US10335142

申请日：2002-12-31

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00 ,  A61B10/00 ,  A61B17/14 ,  A61B17/32 ,  A61M1/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detecting member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 mL of the fluid.

Abstract translation: 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 分析物检测构件定位成从由穿透构件产生的伤口接收流体。 检测构件被配置为使用小于1mL的流体的样品来确定流体中的分析物的浓度。

公开(公告)号：US20080027385A1

公开(公告)日：2008-01-31

申请号：US11539542

申请日：2006-10-06

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B17/14 ,  A61B5/00 ,  A61M5/00 ,  G01N27/26

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  G01N27/28 ,  G06F19/00 ,  G06Q50/24

Abstract: A skin penetrating system is provided with a drive force generator and a disposable housing member. A plurality of penetrating members are positioned in the disposable housing member. Each penetrating member is coupled to the drive force generator. A plurality of analyte detecting members are each associated with a penetrating member and are positioned in the disposable housing member. Each analyte detecting member is positioned in a sample chamber with a volume of less than 1 μL, The sample chambers have openings for transport of a body fluid into the sample chamber. Each analyte detecting member is configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μL of a body fluid disposed in the sample chamber. A user interface is configured to relay at least one of, skin penetrating performance or a skin penetrating setting.

Abstract translation: 皮肤穿透系统设置有驱动力发生器和一次性外壳构件。 多个穿透构件定位在一次性外壳构件中。 每个穿透构件联接到驱动力发生器。 多个分析物检测构件各自与穿透构件相关联并且被定位在一次性外壳构件中。 每个分析物检测构件被定位在体积小于1μL的样品室中。样品室具有用于将体液输送到样品室中的开口。 每个分析物检测构件被配置为使用设置在样品室中的小于1μl体液的样品来确定体液中的分析物的浓度。 用户界面被配置为中继皮肤穿透性能或皮肤穿透设置中的至少一种。

公开(公告)号：US20080021491A1

公开(公告)日：2008-01-24

申请号：US11774778

申请日：2007-07-09

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Jason Hegener

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Jason Hegener

IPC: A61B5/151

CPC classification number: A61B5/15146 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/6886 ,  A61M5/3295

Abstract: A tissue penetrating system has a housing member, a plurality of penetrating members positioned in the housing member and a plurality of sample chambers. Each sample chamber is associated with a penetrating member. A tissue stabilizing member has a tissue interface surface configured to be applied to a tissue surface and provide for spontaneous flow of blood for sample capture. The tissue stabilizing member is coupled to the housing.

Abstract translation: 组织穿透系统具有壳体构件，定位在壳体构件中的多个穿透构件和多个样品室。 每个样品室与穿透构件相关联。 组织稳定构件具有构造成施加到组织表面并提供用于样品捕获的血液的自发流动的组织界面表面。 组织稳定构件联接到壳体。

公开(公告)号：US20070219574A1

公开(公告)日：2007-09-20

申请号：US11691306

申请日：2007-03-26

Applicant: Dominique Freeman ,  Dirk Boecker

Inventor： Dominique Freeman ,  Dirk Boecker

IPC: A61B17/34

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M37/0015

Abstract: A device for use with a penetrating member driver to penetrate tissue is provided. A plurality of penetrating members are coupled to a single cartridge and are operatively couplable to the penetrating member driver. The penetrating members are movable to extend radially outward from the cartridge to penetrate tissue. A plurality of analyte sensors are coupled to the single cartridge and are positioned on the cartridge to receive body fluid from a wound in the tissue created by the penetrating member.