公开(公告)号：US08183252B2

公开(公告)日：2012-05-22

申请号：US12693874

申请日：2010-01-26

申请人： Zhaoning Zhu ,  Zhong-Yue Sun ,  Andrew Stamford ,  William J. Greenlee ,  Jared N. Cumming ,  Lingyan Wang ,  Ulrich Iserloh ,  Xiaoxiang Liu ,  Ying Huang ,  Guoqing Li ,  Jianping Pan

发明人： Zhaoning Zhu ,  Zhong-Yue Sun ,  Andrew Stamford ,  William J. Greenlee ,  Jared N. Cumming ,  Lingyan Wang ,  Ulrich Iserloh ,  Xiaoxiang Liu ,  Ying Huang ,  Guoqing Li ,  Jianping Pan

IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D239/02

CPC分类号： C07D233/88 ,  A61K31/4168 ,  A61K31/4178 ,  C07D239/22 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/10 ,  C07D417/14 ,  C07D495/10

摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

公开(公告)号：US20120094656A1

公开(公告)日：2012-04-19

申请号：US13279688

申请日：2011-10-24

申请人： Ying Huang ,  Li Yang

发明人： Ying Huang ,  Li Yang

IPC分类号： H04W24/00

CPC分类号： H04W36/0055 ,  H04W36/0033 ,  H04W76/19

摘要： A mobile communication method, a device, and a system are provided in embodiments of the present invention, and can ensure service continuity of UEs to the utmost when a cell suddenly fails and cannot work properly.

摘要翻译： 在本发明的实施例中提供了移动通信方法，设备和系统，并且当小区突然失败并且不能正常工作时，可以最大限度地确保UE的业务连续性。

公开(公告)号：US20120002626A1

公开(公告)日：2012-01-05

申请号：US13235170

申请日：2011-09-16

申请人： Jun Wang ,  Xuelong Wang ,  Ying Huang

发明人： Jun Wang ,  Xuelong Wang ,  Ying Huang

IPC分类号： H04W72/04 ,  H04W68/00

CPC分类号： H04W68/00 ,  H04W8/18

摘要： A paging method for a multi-carrier cell includes: receiving a paging message sent by a core network device, where the paging message carries user equipment (UE) information; and obtaining a carrier frequency serving the UE according to the UE information, and paging the UE on the carrier frequency, therefore avoiding a waste of paging resources caused by paging on all frequency bands. By using the preceding method, a waste of common paging resources caused by paging on all carrier frequencies in the multi-carrier cell is avoided.

摘要翻译： 多载波小区的寻呼方法包括：接收由核心网络设备发送的寻呼消息，其中寻呼消息携带用户设备（UE）信息; 并根据UE信息获得服务于UE的载波频率，并在载频上寻呼UE，从而避免了由于对所有频带的寻呼引起的寻呼资源的浪费。 通过使用上述方法，避免了在多载波小区中对所有载波频率上的寻呼引起的普通寻呼资源的浪费。

公开(公告)号：US07910590B2

公开(公告)日：2011-03-22

申请号：US12490884

申请日：2009-06-24

申请人： Ying Huang ,  Guoqing Li ,  Ulrich Iserloh ,  Andrew Stamford ,  Corey Strickland ,  Johannes H. Voigt ,  Jianping Pan

发明人： Ying Huang ,  Guoqing Li ,  Ulrich Iserloh ,  Andrew Stamford ,  Corey Strickland ,  Johannes H. Voigt ,  Jianping Pan

IPC分类号： A61K31/496 ,  A61K31/506

CPC分类号： C04B35/632 ,  C07D207/277 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is X is —O—, —C(R 14)2— or —N(R)—; Z is —C(R14)2— or —N(R)—; t is 0, 1, 2 or 3; each R and R2 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R14 is H, alkyl, alkenyl, alkynyl, halo, —CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, —OR35, —N(R24)(R25) or —SR35; R41 is alkyl, cycloalkyl, —SO2(alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I.Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.

摘要翻译： 公开了下式的新化合物或其药学上可接受的盐或溶剂合物，其中R 1是X是-O - ， - C（R 14）2 - 或-N（R） - ; Z是-C（R 14）2 - 或-N（R） - ; t为0,1,2或3; 每个R和R 2独立地为H，烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，烯基或炔基; 每个R 14是H，烷基，烯基，炔基，卤素，-CN，卤代烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，-OR 35，-N（R 24）（R 25）或-SR 35; R41是烷基，环烷基，-SO2（烷基），-C（O） - 烷基，-C（O） - 环烷基或 - 烷基-NH-C（O）CH3; 其余变量如本说明书中所定义。 还公开了包含式I化合物的药物组合物和用式I化合物治疗认知障碍或神经变性疾病的方法。还公开了药物组合物和治疗方法，其包含式I化合物与用于治疗认知或神经变性的其它药剂 疾病

公开(公告)号：US20110047535A1

公开(公告)日：2011-02-24

申请号：US12771807

申请日：2010-04-30

申请人： Sarabhaiah Polakam ,  Darin Michael DeFer ,  John Andres Lozes ,  Christpher Alan Moore ,  Peter Anthony Tavormina ,  Ying Huang

发明人： Sarabhaiah Polakam ,  Darin Michael DeFer ,  John Andres Lozes ,  Christpher Alan Moore ,  Peter Anthony Tavormina ,  Ying Huang

IPC分类号： G06F9/44

CPC分类号： G06F9/542 ,  G06F8/70 ,  G06F2209/543

摘要： Systems and methods are illustrated that relate to a dynamic configuration of rules (e.g., business rules, presentation rules, etc.) in a virtual machine environment. Moreover, the rules may be updated and used with an application that is running on a virtual machine without requiring the virtual machine to be stopped and started (i.e., restarted). Furthermore, aspects of the disclosure describe managing the visibility of dynamic rules to various applications running on the same virtual machine.

摘要翻译： 示出了与虚拟机环境中的规则（例如，业务规则，呈现规则等）的动态配置相关的系统和方法。 此外，可以更新规则并与虚拟机上运行的应用程序一起使用，而不需要停止并启动虚拟机（即重新启动）。 此外，本公开的方面描述了将动态规则的可视性管理到在相同虚拟机上运行的各种应用。

公开(公告)号：US20110022704A1

公开(公告)日：2011-01-27

申请号：US12826753

申请日：2010-06-30

申请人： Ning Duan ,  Ying Huang ,  Pei Sun ,  Wei Sun ,  Jian Ming Zhang

发明人： Ning Duan ,  Ying Huang ,  Pei Sun ,  Wei Sun ,  Jian Ming Zhang

IPC分类号： G06F15/173

CPC分类号： H04L67/22 ,  G06F16/957

摘要： The present invention provides a computer implemented method and system for collecting information on a user visit for web analytics. An information collection module is sent to a client in response to a page opening request from the client. The information collection module is for collecting additional information on user visit of the client. Additional information on user visit and basic information on user visit of the client is obtained from a web service request. A web beacon request is generated based on the obtained information. The invention adopts a non-intrusive information collection manner that does not require modifying code of a web application and thus, is much simpler, feasible, and cost-effective than prior art. Further, centralized collection and management for the information on user visit can be implemented. Thus, it is more flexible and convenient for maintenance and optimization.

摘要翻译： 本发明提供了一种计算机实现的方法和系统，用于收集关于网页分析的用户访问的信息。 响应于来自客户端的打开页面请求，向客户端发送信息收集模块。 信息收集模块用于收集客户端用户访问的附加信息。 有关用户访问的其他信息和客户端用户访问的基本信息，请从Web服务请求获取。 基于获得的信息生成网络信标请求。 本发明采用不需要修改web应用的代码的非侵入式信息收集方式，因此比现有技术更简单，可行，成本更高。 此外，可以实现对用户访问信息的集中采集和管理。 因此，维护和优化更灵活方便。

公开(公告)号：US07855748B2

公开(公告)日：2010-12-21

申请号：US11949542

申请日：2007-12-03

申请人： Giuseppe Rossi ,  Laurent Blanquart ,  Ying Huang

发明人： Giuseppe Rossi ,  Laurent Blanquart ,  Ying Huang

IPC分类号： H04N5/225

CPC分类号： H03M1/662 ,  H03M1/76 ,  H04N5/335 ,  H04N5/3698

摘要： The claimed subject matter provides systems and/or methods that facilitate generating and/or maintaining low noise reference voltages for CMOS imaging System-on-Chip (iSoC) sensors. A primary reference voltage can be generated utilizing a low noise bandgap. Further, the primary reference voltage can be filtered via a low pass filter. The filtered, primary reference voltage can thereafter be distributed to a plurality of isolated domains. Each of the isolated domains can generate an independent set of reference voltages based upon the filtered, primary reference voltage. Moreover, subsets of these reference voltages can be employed by programmable digital to analog converters (DACs). Each of the reference voltages can be isolated from switching noise and/or clock glitches generated within each domain. Further, each DAC output can be buffered to have adequately low impedance with appropriate drive capability and requisite signal swing.

摘要翻译： 所要求保护的主题提供了有助于为CMOS成像片上系统（iSoC）传感器产生和/或维持低噪声参考电压的系统和/或方法。 可以利用低噪声带隙产生主参考电压。 此外，可以通过低通滤波器对初级参考电压进行滤波。 滤波后的主参考电压此后可以分配到多个隔离域。 每个隔离域可以基于滤波的主要参考电压产生独立的一组参考电压。 此外，这些参考电压的子集可由可编程数模转换器（DAC）采用。 每个参考电压可以与每个域内产生的开关噪声和/或时钟毛刺隔离。 此外，每个DAC输出可以被缓冲以具有适当的低阻抗，具有适当的驱动能力和必要的信号摆幅。

公开(公告)号：US20100178294A1

公开(公告)日：2010-07-15

申请号：US12571840

申请日：2009-10-01

申请人： Andrew W. Stamford ,  Ying Huang ,  Guoqing Li ,  Corey O. Strickland ,  Johannes H. Voigt

发明人： Andrew W. Stamford ,  Ying Huang ,  Guoqing Li ,  Corey O. Strickland ,  Johannes H. Voigt

IPC分类号： A61K39/395 ,  C07D413/06 ,  A61K31/496 ,  C07D498/04 ,  A61P25/28 ,  A61P25/00

CPC分类号： C07D498/04 ,  C07D413/06

摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula I and at least one compound selected from the group consisting of β-secretase inhibitors other than those of formula I, HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.

摘要翻译： 公开了下式的新化合物或其药学上可接受的盐或溶剂化物，其中R1，R2，R3，n和X如说明书中所定义。 还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。 还公开了治疗认知或神经退行性疾病的方法，包括向需要这种治疗的患者施用至少一种式I化合物和至少一种选自除了那些的那些之外的其他化合物 式I，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，非甾体抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂和抗淀粉样蛋白抗体。

公开(公告)号：US07686934B2

公开(公告)日：2010-03-30

申请号：US11638093

申请日：2006-12-12

申请人： Dalibor Hodko ,  Ying Huang ,  Daniel D. Smolko

发明人： Dalibor Hodko ,  Ying Huang ,  Daniel D. Smolko

IPC分类号： G01N27/447 ,  G01N27/453

CPC分类号： G01N27/447 ,  B03C5/005 ,  B03C5/026

摘要： Devices and methods for performing separation of cell particles by dielectrophoresis in three dimensions. In one embodiment the device comprises a flow chamber having microfabricated chip with a plurality of vertical and horizontal electrodes, which may be coated with a protective layer to prevent direct contact between any electrode and a sample. The horizontal electrodes are in electrical communication with a DC or an AC power source, while the vertical electrodes are in electrical communication with an AC power source.

摘要翻译： 用于通过介电电泳在三维中进行细胞颗粒分离的装置和方法。 在一个实施例中，该装置包括具有多个垂直和水平电极的微加工芯片的流动室，其可以涂覆有保护层，以防止任何电极和样品之间的直接接触。 水平电极与DC或AC电源电连通，而垂直电极与AC电源电连通。

公开(公告)号：US20080274959A1

公开(公告)日：2008-11-06

申请号：US11794068

申请日：2005-12-16

申请人： Bradley A. Haltli ,  Haiyin He ,  Ying Huang ,  Sridhar Krishna Rabindran ,  Jiang Wu ,  Min He

发明人： Bradley A. Haltli ,  Haiyin He ,  Ying Huang ,  Sridhar Krishna Rabindran ,  Jiang Wu ,  Min He

IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/15 ,  C12P21/00 ,  C07H17/08 ,  C07K14/37 ,  G01N33/566 ,  C12N1/14 ,  G01N33/53 ,  A61P35/00

CPC分类号： C12N15/52

摘要： The present invention provides a chromoprotein produced by Actinomadura sp. 21G792, as well as amino acid and nucleic acid sequences of the apoprotein component of the chromoprotein and of components of the biosynthetic pathway for the chromophore. The present invention is useful for developing pharmaceutical and treating diseases such as cancer or bacterial infections.

摘要翻译： 本发明提供由放线菌属（Actinomadura sp。）生产的色素蛋白 21G792，以及发色蛋白的脱辅基蛋白组分的氨基酸和核酸序列以及发色团的生物合成途径的组分。 本发明可用于开发药物和治疗诸如癌症或细菌感染的疾病。