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公开(公告)号：US20100041014A1
公开(公告)日：2010-02-18
申请号：US12228880
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： G01N33/555 , A61K31/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
摘要翻译： 描述了改良的红细胞。 在一个实施方案中，修饰的红细胞包括靶结合剂。 描述了使用修饰的红细胞靶向递送成像剂，药物和肽和蛋白质药物。 描述了制备改性红细胞的方法，含有其的药物和诊断组合物以及涉及修饰的红细胞的诊断和治疗方法。
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公开(公告)号：US20100040546A1
公开(公告)日：2010-02-18
申请号：US12228892
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61K41/0028 , A61K41/0071 , A61K47/6901 , A61K49/0002 , A61K49/0097 , A61K49/0409 , G01N33/542 , G01N33/586 , G01N2458/30 , Y02A50/52 , Y02A50/58
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US20090137866A1
公开(公告)日：2009-05-28
申请号：US11998438
申请日：2007-11-28
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61B1/00
CPC分类号： A61B5/4839 , A61B1/00016 , A61B1/00147 , A61B1/041 , A61B5/01 , A61B5/036 , A61B5/073 , A61B5/076 , A61B5/14539 , A61B5/42 , A61B7/008 , A61M31/002
摘要： Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more.
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公开(公告)号：US20090112191A1
公开(公告)日：2009-04-30
申请号：US12002777
申请日：2007-12-17
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61B5/0008 , A61B5/0031 , A61B5/036 , A61B5/053 , A61B5/062 , A61B5/073 , A61B5/145 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4839 , A61B5/6861 , A61B7/008 , A61K9/0097
摘要： Systems and methods are described for implementing or deploying medical or veterinary utility modules comprising a first module operable in a digestive or respiratory tract to engage a second module, optionally by a magnetic field. Alternatively or additionally, systems may be operable to remain in situ and also operable to permit a therapeutic material dispensation. In some contexts, for example, systems or methods may dispense a therapeutic material via a subject's throat or elsewhere in the digestive or respiratory tract.
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公开(公告)号：US20090104250A1
公开(公告)日：2009-04-23
申请号：US11998152
申请日：2007-11-27
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61B5/0008 , A61B5/036 , A61B5/073 , A61B5/076 , A61B5/14503 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4839 , A61B5/6882 , A61B7/008
摘要： Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more.
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公开(公告)号：US20090112048A1
公开(公告)日：2009-04-30
申请号：US11982448
申请日：2007-10-31
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61N2/06 , A61B5/0008 , A61B5/0031 , A61B5/036 , A61B5/053 , A61B5/062 , A61B5/073 , A61B5/145 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4839 , A61B5/6861 , A61B7/008 , A61M31/002 , A61N1/0517 , A61N1/0519 , A61N1/36007
摘要： Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more.
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公开(公告)号：US20090192449A1
公开(公告)日：2009-07-30
申请号：US10536126
申请日：2007-10-23
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61B5/07 , A61B5/14532 , A61B5/42
摘要： Systems and methods are described for implementing a bioactive material selection from within a digestive tract and transmitting a wireless signal indicating at least the bioactive material selection from within the digestive tract.
摘要翻译： 描述了用于从消化道内进行生物活性材料选择的系统和方法，并且从消化道内传输至少指示生物活性材料选择的无线信号。
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公开(公告)号：US20090105531A1
公开(公告)日：2009-04-23
申请号：US11975371
申请日：2007-10-17
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61B1/273
CPC分类号： A61B5/073 , A61B5/42 , A61B5/4839 , A61B5/6861
摘要： Systems and methods are described for configuring several modules each individually small enough to pass through a digestive tract; and a tether or other means for releasably configuring at least the several modules in a group. Such a tether may (directly or indirectly) couple some of the modules via at least a gap in another module from which the tether may slip free, in some embodiments. Such methods may include modes of administering a medication or otherwise taking an action in response to the one or more phenomena.
摘要翻译： 描述了用于配置几个模块的系统和方法，每个模块各自足够小以通过消化道; 以及用于可释放地配置组中的至少几个模块的系绳或其他装置。 在一些实施例中，这样的系绳可以（直接或间接地）通过至少一个模块中的一些间隙耦合一些模块，系绳可从该间隙滑脱。 这样的方法可以包括施用药物或以其他方式响应于一种或多种现象采取行动的模式。
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公开(公告)号：US20090163894A1
公开(公告)日：2009-06-25
申请号：US12002296
申请日：2007-12-14
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61M5/14276 , A61M5/14248 , A61M2210/1032 , A61M2210/1042
摘要： Systems and methods are described for implementing or deploying medical or veterinary utility modules comprising a first module operable in a digestive or respiratory tract to engage a second module, optionally by a magnetic field. Alternatively or additionally, systems may be operable to remain in situ and also operable to permit a therapeutic material dispensation. In some contexts, for example, systems or methods may dispense a therapeutic material via a subject's throat or elsewhere in the digestive or respiratory tract.
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公开(公告)号：US20090110714A1
公开(公告)日：2009-04-30
申请号：US12002288
申请日：2007-12-13
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M37/00
CPC分类号： A61M31/002
摘要： Systems and methods are described for implementing or deploying medical or veterinary utility modules comprising a first module operable in a digestive or respiratory tract to engage a second module, optionally by a magnetic field. Alternatively or additionally, systems may be operable to remain in situ and also operable to permit a therapeutic material dispensation. In some contexts, for example, systems or methods may dispense a therapeutic material via a subject's throat or elsewhere in the digestive or respiratory tract.
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