摘要:
A method for making a pharmaceutical by emulsion aggregation, the method including emulsifying a first pharmaceutical agent and a biodegradable resin to form a primary emulsion of pre-aggregated particles in a slurry; aggregating the pre-aggregated particles to form aggregated pharmaceutical particles in the slurry; and isolating the pharmaceutical particles. The method may be used to make time-released, multi-formulation, and inhalable pharmaceuticals.
摘要:
A process for making particles is provided. In embodiments, a suitable process includes adding a rheology modifier to an emulsion utilized to form toner particles. The rheology modifier permits the use of a higher solid content in the emulsion, with a resulting higher yield of toner particles, without requiring the use of powerful mixing equipment.
摘要:
A process for making a resin emulsion suitable for use in forming toner particles is provided. In embodiments, a suitable process includes melt mixing a resin in the absence of an organic solvent, optionally adding a surfactant to the resin, adding to the resin a basic agent and water, and subjecting the resin, basic agent and water to acoustic mixing at a suitable frequency to form an emulsion of resin particles. In embodiments, the resin emulsion thus produced may be utilized to form a toner.
摘要:
A process for preparing a toner includes mixing a polymeric resin emulsion, a colorant dispersion, and a wax to form a mixture; optionally adding a coagulant to the mixture; heating the mixture at a temperature below a glass transition temperature of the polymeric resin to aggregate the polymeric resin, colorant, and wax, to form aggregated particles; adding a coalescent agent to the aggregated particles; heating the aggregated particles and coalescent agent at a temperature above the glass transition temperature of the polymeric resin, to coalesce the aggregated particles to form toner particles, optionally cooling the mixture, and isolating the tone particles.
摘要:
Polymeric microcarriers suitable for use in cell culture processes and the methods of making such polymeric microcarriers by emulsion/aggregation polymerization processes.
摘要:
Imaging members useful in electrostatographic apparatuses, including printers, copiers, other reproductive devices, and digital apparatuses. More particularly, imaging members having nano-sized particles serving as fillers dispersed or contained in one or more layers of the imaging member that provide for increased mechanical strength and improved wear.
摘要:
Porous polymer microspheres having a size of from about 3 to about 50 microns and a geometric standard deviation of about 1.25 or less are disclosed. The porous polymer microspheres are made by a method including the steps of preparing an emulsion comprised of polymer particles having an average particle size of less than about 3 microns and a diluent, subjecting the emulsion to an aggregating condition to form aggregated polymer particles, optionally coalescing the aggregated polymer particles, and removing the diluent to form the porous polymer microspheres.
摘要:
Porous polymer microspheres having a size of from about 3 to about 50 microns and a geometric standard deviation of about 1.25 or less are disclosed. The porous polymer microspheres are made by a method including the steps of preparing an emulsion comprised of polymer particles having an average particle size of less than about 3 microns and a diluent, subjecting the emulsion to an aggregating condition to form aggregated polymer particles, optionally coalescing the aggregated polymer particles, and removing the diluent to form the porous polymer microspheres.
摘要:
Processes for producing toner are provided which utilize reactive coalescing agents in forming the toner particles, as well as toners produced by such processes.