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公开(公告)号：US20240024199A1
公开(公告)日：2024-01-25
申请号：US18363887
申请日：2023-08-02
CPC分类号： A61J1/2062 , A61J1/201 , A61J1/2037 , A61J1/2048 , A61J1/2075 , A61J1/2082 , A61J1/1406 , A61J1/16 , A61J1/18 , A61J1/2096 , B01F31/265 , A61M5/2066 , A61J1/20 , A61J2200/76 , A61J2205/20 , B01F2215/0454 , B01F2101/2202
摘要： An automated transfer and mixing device receives an injection device, a lyophilized drug vial and a diluent vial and transfers diluent from the diluent vial to the lyophilized drug vial and shakes or vibrates the lyophilized drug vial to reconstitute the drug. The device then transfers the reconstituted drug from the lyophilized drug vial to the injection device.
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公开(公告)号：US09776149B2
公开(公告)日：2017-10-03
申请号：US13724796
申请日：2012-12-21
申请人： Covaris, Inc.
CPC分类号： B01F11/0283 , B01F3/0807 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01J2/18 , B01J2219/00932
摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents, e.g., a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent.
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3.发明申请公开(公告)号：US20160375413A1
公开(公告)日：2016-12-29
申请号：US15235423
申请日：2016-08-12
CPC分类号： B01F5/0085 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F13/0059 , B01F13/0062 , B01F13/0069 , B01F2003/0838 , B01F2005/0034 , B01F2215/0404 , B01F2215/0431 , B01F2215/0454 , B01F2215/0495 , B01J13/04 , B01J13/12 , B01J13/14 , Y10T428/2985
摘要： Multiple emulsions and techniques for the formation of multiple emulsions are generally described. A multiple emulsion, as used herein, describes larger droplets that contain one or more smaller droplets therein. In some embodiments, the larger droplet or droplets may be suspended in a carrying fluid containing the larger droplets that, in turn, contain the smaller droplets. As described below, multiple emulsions can be formed in one step in certain embodiments, with generally precise repeatability, and can be tailored in some embodiments to include a relatively thin layer of fluid separating two other fluids.
摘要翻译： 通常描述用于形成多重乳液的多重乳液和技术。 本文所用的多重乳液描述了在其中含有一个或多个较小液滴的较大液滴。 在一些实施方案中，较大的液滴或液滴可以悬浮在含有较大液滴的携带液体中，而液滴又包含较小的液滴。 如下所述，在某些实施方案中可以在一个步骤中形成多个乳液，具有大致精确的重复性，并且可以在一些实施方案中调整为包括分离两个其它流体的相对薄的流体层。
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4.发明申请公开(公告)号：US20160235667A1
公开(公告)日：2016-08-18
申请号：US15026318
申请日：2014-10-01
申请人： VECTURA LIMITED
发明人： MATTHEW GREEN
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K9/1682 , B01F3/18 , B01F11/02 , B01F2215/0032 , B01F2215/0431 , B01F2215/044 , B01F2215/0454 , B01F2215/0477 , C07K16/4291 , C07K2317/21 , C07K2317/24 , C07K2317/52
摘要： A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising a pharmaceutically active protein or nucleic acid particle, the method comprising a step in which the inhalable pharmaceutically active protein or nucleic acid particle is acoustically blended in a resonant acoustic blender. The invention also relates to compositions for inhalation prepared by the method.
摘要翻译： 公开了一种制备用于肺部给药的药物组合物的方法，其包含药物活性蛋白质或核酸颗粒，所述方法包括将可吸入的药物活性蛋白质或核酸颗粒在共振声学混合器中声学混合的步骤。 本发明还涉及通过该方法制备的用于吸入的组合物。
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5.发明申请SYNTHESIS OF SILK FIBROIN MICRO- AND SUBMICRON SPHERES USING A CO-FLOW METHOD 审中-公开使用共同流动方法合成丝状纤维素微球和亚细胞球公开(公告)号：US20160215103A1
公开(公告)日：2016-07-28
申请号：US15025140
申请日：2014-09-26
申请人： TUFTS UNIVERSITY
发明人： Fiorenzo Omenetto , Giovanni Perotto , Benedetto Marelli , David Kaplan , Alexander Mitropoulos
IPC分类号： C08J3/12 , C07K1/02 , C07K14/435
CPC分类号： C08J3/12 , A61K9/5169 , B01F3/0807 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B82Y5/00 , C07K1/02 , C07K14/43504 , C08J2389/00
摘要： This application relates to silk fibroin particles that are structurally uniform. Related methods are also disclosed.
摘要翻译： 本申请涉及结构均匀的丝素蛋白颗粒。 还公开了相关方法。
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公开(公告)号：US09346864B2
公开(公告)日：2016-05-24
申请号：US13985800
申请日：2012-02-15
申请人： Thorsten Luehrs , Felix Deluweit
发明人： Thorsten Luehrs , Felix Deluweit
CPC分类号： B01F11/0225 , B01F7/00008 , B01F7/00541 , B01F7/008 , B01F11/0258 , B01F13/0836 , B01F13/0845 , B01F15/00006 , B01F15/00389 , B01F15/00707 , B01F15/0072 , B01F2215/0073 , B01F2215/0427 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01F2215/0481 , C07K14/47
摘要： The invention provides a method for producing prion protein having an aggregated conformation by contacting native conformation prion protein with aggregated conformation prion protein in a liquid preparation and subjecting this to at least one cycle or to a number of cycles of application of shear-force for fragmenting aggregates of prion protein, wherein the shear-force applied is precisely controlled. In addition to this process for amplification of aggregated state prion protein from native conformation prion protein, the invention relates to the aggregated state prion protein obtained by the amplification process, which aggregated state prion protein has one conformation, which is e.g. identical within one batch and reproducible between batches, e.g. as detectable by proteinase resistance in a Western blot.
摘要翻译： 本发明提供了通过使天然构象朊病毒蛋白与聚集的构象朊病毒蛋白在液体制剂中接触而制备具有聚集构象的朊病毒蛋白的方法，并且对其进行至少一个循环或多个施加剪切力以循环的循环 朊病毒蛋白的聚集体，其中施加的剪切力被精确地控制。 本发明涉及通过扩增方法获得的聚合状态朊病毒蛋白，该聚合状态朊病毒蛋白具有一个构象。 在一批内相同，并且在批次之间可再现。 在Western印迹中可通过蛋白酶抗性检测。
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公开(公告)号：US08784848B2
公开(公告)日：2014-07-22
申请号：US13379652
申请日：2010-06-22
CPC分类号： B01F3/0819 , B01F3/0811 , B01F11/0258 , B01F2003/0834 , B01F2003/0842 , B01F2215/0454
摘要： The invention relates to a method for preparing a stable oil-in-water emulsion without adding an emulsifier. According to the method, a mixture of a lipid phase and an aqueous phase is subjected to vibrating energy, in a sealed container, by applying a transducer operating at a frequency of more than 900 kHz.
摘要翻译： 本发明涉及一种在不添加乳化剂的情况下制备稳定的水包油乳液的方法。 根据该方法，通过施加以大于900kHz的频率工作的换能器，在密封容器中，将脂质相和水相的混合物进行振动能。
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8.发明申请COMPOSITIONS AND METHODS FOR PREPARING NANOFORMULATIONS AND SYSTEMS FOR NANO-DELIVERY USING FOCUSED ACOUSTICS 有权使用焦点声学处理纳米交付纳米生成和系统的组合物和方法公开(公告)号：US20130155802A1
公开(公告)日：2013-06-20
申请号：US13724796
申请日：2012-12-21
申请人： Covaris, Inc.
IPC分类号： B01F11/02
CPC分类号： B01F11/0283 , B01F3/0807 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01J2/18 , B01J2219/00932
摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents, e.g., a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent.
摘要翻译： 聚焦超音波处理用于制备约10nm至约50微米（例如，1微米至20微米）之间或约10nm约400nm（例如，10nm至100nm）之间的制剂颗粒。 制剂（例如，纳米制剂）可以包括悬浮液（例如纳米悬浮液），乳剂（例如纳米乳剂）或另一小颗粒系统。 制剂可以用作治疗剂的递送系统，例如，制剂可以包括生物活性剂和载体化合物，例如包封生物活性剂的表面活性剂。
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公开(公告)号：US08263005B2
公开(公告)日：2012-09-11
申请号：US11894805
申请日：2007-08-20
CPC分类号： B01F13/0059 , B01F11/02 , B01F11/0283 , B01F13/0222 , B01F13/0277 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J19/0046 , B01J19/008 , B01J19/0093 , B01J19/10 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00486 , B01J2219/00495 , B01J2219/00659 , B01J2219/00722 , B01J2219/00783 , B01J2219/00889 , B01L3/50273 , B01L3/5085 , B01L2400/0436 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
摘要： The present invention provides systems, methods, and devices for using acoustic energy.
摘要翻译： 本发明提供了用于使用声能的系统，方法和装置。
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公开(公告)号：US20120183584A1
公开(公告)日：2012-07-19
申请号：US13379652
申请日：2010-06-22
CPC分类号： B01F3/0819 , B01F3/0811 , B01F11/0258 , B01F2003/0834 , B01F2003/0842 , B01F2215/0454
摘要： The invention relates to a method for preparing a stable oil-in-water emulsion without adding an emulsifier. According to the method, a mixture of a lipid phase and an aqueous phase is subjected to vibrating energy, in a sealed container, by applying a transducer operating at a frequency of more than 900 kHz.
摘要翻译： 本发明涉及一种在不添加乳化剂的情况下制备稳定的水包油乳液的方法。 根据该方法，通过施加以大于900kHz的频率工作的换能器，在密封容器中，将脂质相和水相的混合物进行振动能。
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