公开(公告)号：US20100236324A1

公开(公告)日：2010-09-23

申请号：US12665430

申请日：2007-06-18

申请人： Hideji Tajima ,  Osamu Takigawa ,  Masanari Tsujimura

发明人： Hideji Tajima ,  Osamu Takigawa ,  Masanari Tsujimura

IPC分类号： G01N35/10 ,  G01N30/04

CPC分类号： G01N35/10 ,  G01N1/405 ,  G01N30/6043 ,  G01N30/6091 ,  G01N2035/1053

摘要： The present invention relates to a column tip processing device and a column tip processing method, and its objective is to enhance the contact between a packing and a fluid as a subject to be processed whereby accomplishing a highly efficient reaction as well as an accurate processing, which has a nozzle head having a single or multiple-channeled nozzle, a suction and discharge mechanism, one or more types of column tips in which a packing is enclosed, a stage provided with a fluid housing part group including a plurality of fluid housing parts in which various solutions are or can be housed, and moving means for moving the nozzle head relatively to the fluid housing part group, and also has a controlling part which controls the suction and discharge mechanism and the moving means with regard to quantities, pressure, flow rate, the number of cycles, time or position of the suction or discharge by the nozzle based on a structural requirement relating to the structure of the one or more types of column tips to be fitted to the nozzle and a processing requirement relating to the processing contents involving one or more types of subject fluids subjected to the suction or discharge of the column tips.

摘要翻译： 本发明涉及柱尖处理装置和柱尖处理方法，其目的是增强填料和作为待处理对象的流体之间的接触，从而实现高效反应以及精确的处理， 其具有具有单通道或多通道喷嘴的喷嘴头，抽吸和排出机构，其中封装有填料的一种或多种类型的塔尖，设置有包括多个流体容纳部分的流体容纳部分组 其中各种解决方案是或可以容纳的，以及用于相对于流体容纳部分组移动喷嘴头的移动装置，并且还具有控制部分，其控制吸入和排出机构以及移动装置的数量，压力， 基于与一个或多个结构相关的结构要求，喷嘴的吸入或排出的流量，循环次数，时间或位置 要安装到喷嘴的柱头类型以及涉及处理内容的处理要求涉及一种或多种类型的受到吸收或排出柱头的主体流体。

公开(公告)号：US20100137165A1

公开(公告)日：2010-06-03

申请号：US12448635

申请日：2008-02-06

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： C40B50/18 ,  C40B60/14

CPC分类号： G01N35/0098 ,  G01N35/1065 ,  G01N2035/1053 ,  Y10T436/25375

摘要： To provide a magnetic particle parallel processing apparatus permitting repeated use of a container, and a method of magnetic particle parallel processing permitting repeated use of a container, with which the rate of repeated use of a container is enhanced to thereby achieve a saving in the working space and a saving in the working time. The apparatus comprises: at least one reaction container; a liquid disposal tank; a reagent etc. feeder with at least one flow channel for feeding at least one type of liquid selected from the group consisting of two or more types of solutions and a magnetic particle suspension according to the processing content, at a given amount and at a given timing, to the reaction container; and a magnetic separator which has at least one processing nozzle with a distal end insertable into the reaction container and the liquid disposal tank, for sucking and discharging a liquid through the distal end, and which also has a magnetic means capable of applying a magnetic field to the interior of the distal end to thereby attract magnetic particles contained in the liquid inside the distal end to the inner wall thereof to effect separation of the magnetic particles, and canceling the magnetic field to thereby release the attracted magnetic particles and re-suspend the same in a liquid.

摘要翻译： 为了提供允许反复使用容器的磁性颗粒并行处理装置，以及允许重复使用容器的磁性颗粒并行处理方法，通过该容器重复使用容量，从而实现了工作中的节省 空间和节省工作时间。 该装置包括：至少一个反应容器; 液体处理罐; 具有至少一个流动通道的试剂等进料器，用于根据处理内容，给定量和给定的至少一种流动通道，供给选自两种或更多种类型的溶液和磁性颗粒悬浮液的至少一种液体 正时，反应容器; 以及磁选机，其具有至少一个处理喷嘴，其具有可插入到反应容器和液体处理槽中的远端，用于通过远端吸取和排出液体，并且还具有能够施加磁场的磁性装置 到远端的内部，从而将包含在前端内部的液体中的磁性粒子吸引到其内壁，以实现磁性粒子的分离，并消除磁场，从而释放被吸引的磁性粒子，并重新悬挂 在液体中相同。

公开(公告)号：US20100119416A1

公开(公告)日：2010-05-13

申请号：US11794828

申请日：2006-01-06

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： B01L3/00

CPC分类号： B01L3/00 ,  B01D15/22 ,  B01J2220/64 ,  B01L3/0275 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/1827 ,  C07K1/16 ,  C07K1/22 ,  G01N1/405 ,  G01N30/6091

摘要： A carrier enclosing chip; a carrier treating apparatus; and a method of carrier treatment. It is intended to carry out separation/purification with increased efficiency and rapidity as compared with those of treatment using conventional liquid chromatograph or filter. There is provided a carrier enclosing chip comprising a nozzle for gas suction and discharge, or opening for fitting fittable to a member fitted to a nozzle; a container of chip form having a port through which fluid inflow and outflow can be effected by the gas suction and discharge; and a carrier enclosed in the container of chip form, the carrier capable of adsorption of any biosubstance contained in the fluid or capable of reaction with or binding to the biosubstance.

摘要翻译： 载体封装芯片; 载体处理装置; 和载体处理方法。 与使用常规液相色谱仪或过滤器的处理相比，旨在提高效率和快速性进行分离/纯化。 提供了一种载体包围芯片，其包括用于气体吸入和排出的喷嘴，或者开口用于可装配到安装到喷嘴的构件的装配; 具有端口的芯片形式的容器，通过该端口可以通过气体吸入和排出来实现流体的流入和流出; 以及封装在芯片形式的容器中的载体，载体能够吸附流体中包含的任何生物物质或能够与生物物质反应或结合生物物质。

公开(公告)号：US20100047132A1

公开(公告)日：2010-02-25

申请号：US12225747

申请日：2007-03-28

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： B01L99/00

CPC分类号： G01N1/28 ,  B01L3/5085 ,  B01L9/54 ,  B01L2200/141 ,  B01L2300/0829 ,  G01N35/1074 ,  Y10T436/2575

摘要： An object is to provide a micro plate treating device and micro plate treating method capable of handling a larger number of kinds of solution or suspensions or a larger volume of solutions or suspensions per work area by use of a normalized micro plate without enlarging the scale of the device.The micro plate treating device comprises a micro plate having wells arranged in a matrix form, one or two or more nozzle heads each having nozzles capable of sucking and discharging a fluid and arranged in a matrix form, and moving means capable of moving relatively an interval between the micro plate and the nozzle heads, wherein tips of all the nozzles are configured to be permitted to be simultaneously inserted into some of the wells in the micro plate, at least one of the row interval or the column interval of the nozzles is set to a natural number multiple of the row interval or the column interval of the corresponding wells, the natural number being two or more, and at least one of the row number or the column number of all the corresponding nozzles is one to the natural number of the row number or the column number of the wells.

摘要翻译： 目的是提供一种微板处理装置和微板处理方法，其能够通过使用归一化的微板处理更多数量的溶液或悬浮液或每个工作区域的较大体积的溶液或悬浮液，而不会扩大规模 装置。 微板处理装置包括具有以矩阵形式布置的孔的微板，每个具有能够吸取和排出流体并且以矩阵形式布置的喷嘴的一个或两个或更多个喷嘴头以及能够相对间隔地移动的移动装置 在微板和喷嘴头之间，其中所有喷嘴的末端被配置为允许同时插入微板中的一些孔中，设置喷嘴的行间隔或列间隔中的至少一个 到对应孔的行间隔或列间隔的自然数倍，自然数为两个或更多个，并且所有相应喷嘴的行数或列数中的至少一个为自然数 井的行号或列号。

公开(公告)号：US20100043575A1

公开(公告)日：2010-02-25

申请号：US12448689

申请日：2008-01-21

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： B01L3/02 ,  G01N1/14

CPC分类号： B01L3/0275 ,  B01D15/3804 ,  B01J2220/64 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/069 ,  G01N30/6043 ,  G01N2035/1053

摘要： The present invention relates to a pipette tip having a support and a fluid enclosed therein, an apparatus for treating the pipette tip having a support and a fluid enclosed therein, and a method of treating the pipette tip having a support and a fluid enclosed therein. The present invention aims at providing separation and purification that may be performed more efficiently and rapidly than the treatments using a conventional treatment using liquid chromatograph or a filter, and constituted to have a function for sustainedly activating the support by comprising a pipette tip comprising an attachment opening that is to be attached to a nozzle for sucking and discharging a gas or to a connecting tube attachable to the nozzle and may be communicated with the nozzle, and an opening that allows flow-in and flow-out of a liquid in response to the suction and discharging of the gas; a support enclosed in the pipette tip, which may adsorb or capture a biological material in the liquid or react with or bond to the biological material; and a fluid for sustainedly activating the support, which comprises a predetermined liquid or a predetermined gas that is enclosed in the pipette tip in a breakable state and comes into contact with the support.

摘要翻译： 本发明涉及具有支撑体和封闭在其中的流体的移液管尖端，用于处理具有支撑件和封闭在其中的流体的移液管尖端的装置，以及处理具有支撑件的移液管尖端和封闭在其中的流体的方法。 本发明旨在提供可以比使用液相色谱仪或过滤器的常规处理的处理更有效和快速地进行的分离和纯化，并且构成为具有通过包括附着物的移液管尖端来持续活化载体的功能 要连接到用于吸入和排出气体的喷嘴的开口或连接到喷嘴的连接管，并且可以与喷嘴连通，以及允许响应于流体流动而流入和流出液体的开口 气体的吸入和排出; 包封在移液管尖端的支架，其可以吸附或捕获液体中的生物材料或与生物材料反应或结合到生物材料上; 以及用于持续地启动支撑件的流体，其包括预定液体或预定的气体，所述预定液体或预定气体以可破坏的状态包封在吸头中并与支撑体接触。

公开(公告)号：US07667184B2

公开(公告)日：2010-02-23

申请号：US11568384

申请日：2005-04-28

申请人： Masahisa Noguchi ,  Ken Tsukii ,  Hideji Tajima

发明人： Masahisa Noguchi ,  Ken Tsukii ,  Hideji Tajima

IPC分类号： G06M7/00 ,  G01J1/04 ,  G01N21/01 ,  G02B6/00

CPC分类号： G01N21/645 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6484

摘要： The invention aims to provide an optical information reader which can identify precisely, reliably, and with high sensitivity, even when the quantity or the wavelength of light from a measuring object from which optical information is to be read, extends over a wide range. The optical information reader comprises: a substrate on which one or more biological materials labeled by a combination of presence or extent of a plurality of kinds of optical labeling elements are immobilized at one or more different immobilized positions; one or more light-receiving ends capable of receiving light from the substrate; an optical information measuring unit which obtains optical information on a specific measuring object on the substrate based on an electric signal obtained by converting the light received by the light-receiving end by photoelectric elements having different characteristics determined depending on the measuring object; and a scanning unit which scans the substrate by moving the substrate and the light-receiving end relative to each other, and the optical information measuring unit has an optical waveguide.

摘要翻译： 本发明的目的在于提供一种光学信息读取器，即使在来自测量对象的光量的信息的量或波长在宽范围内延伸的情况下，也能够精确，可靠，高灵敏度地进行识别。 光学信息读取器包括：在一个或多个不同的固定位置固定有一个或多个由多种光学标记元件的存在或程度组合标记的生物材料的基底; 能够从基板接收光的一个或多个光接收端; 光学信息测量单元，其基于通过根据测量对象确定的具有不同特性的光电元件转换由光接收端接收的光而获得的电信号，获得关于基板上的特定测量对象的光学信息; 以及扫描单元，其通过相对于彼此移动所述基板和所述光接收端来扫描所述基板，并且所述光学信息测量单元具有光波导。

公开(公告)号：US20100015010A1

公开(公告)日：2010-01-21

申请号：US12304596

申请日：2007-06-12

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： B01L3/00 ,  B65D37/00

CPC分类号： G01N1/405 ,  B01L3/021 ,  B01L3/0275 ,  B01L3/508 ,  B01L9/543 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0838 ,  B01L2400/0481 ,  G01N35/1074 ,  Y10T436/25375

摘要： Provided are a carrier-enclosed transformable container, a carrier-enclosed transformable container processing apparatus, and a carrier-enclosed transformable container processing method about which a carrier to which various substances such as biogenic substances are bonded or bondable is held in a transformable container as the container to be in a substantially stationary state, thereby making it possible to make the handling of the carrier, measurement, and other treatments effective, speedy, and easy. The container is formed to have: a containing part which can contain liquid and gas at its inside surrounded by a wall face, a part of this wall face having a transformable wall face capable of undergoing a predetermined transformation without changing the entire internal surface area of the wall face substantially; an orifice part which is connected to the containing part and can undergo the inflow and outflow of a liquid sucked and discharged by the expansion and contraction of the inside by the transformation of the transformable wall face, respectively; and a carrier to which a predetermined substance enclosed in the containing part to be in a substantially stationary state is bonded or bondable.

摘要翻译： 本发明提供一种载体封闭的可变形容器，载体封闭的可变形的容器处理装置和载体封闭的可变形的容器处理方法，将可生物源物质等各种物质结合或粘合的载体保持在可变形的容器中 该容器处于基本静止的状态，从而可以使载体的处理，测量和其它处理有效，快速和容易。 容器形成为具有容纳部，该容纳部在其内侧包围有壁面的内部容纳有液体和气体，该壁面的一部分具有可变形的壁面，能够进行预定的变形，而不改变整个内表面积 壁面基本上; 孔部分，其连接到容纳部分，并且可以分别通过可变形壁面的变换而经受由内部的膨胀和收缩而吸出和排出的液体的流入和流出; 并且将包围在所述容纳部中的处于基本上静止状态的预定物质接合或可粘合的载体。

公开(公告)号：USD601712S1

公开(公告)日：2009-10-06

申请号：US29303831

申请日：2008-02-19

申请人： Hideji Tajima

设计人： Hideji Tajima

公开(公告)号：US20080193995A1

公开(公告)日：2008-08-14

申请号：US11792835

申请日：2005-12-12

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： C12N11/00 ,  C12M1/00

CPC分类号： B01L3/502 ,  B01L3/0275 ,  B01L2200/0631 ,  B01L2200/0647 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/12 ,  G01N35/10 ,  G01N2035/1053

摘要： A biological material fixed carrier enclosing tip, a biological material fixed carrier treatment apparatus, and a treatment method thereof. An object is to obviate attachment control and suction control for storing and retaining the carrier in the tip form vessel, to simplify complex reaction processes, and to make processing of the biological material fixed carrier to be easily executed as a result of a small-scale device configuration. The biological material fixed carrier enclosing tip comprises: a tip form vessel having an installation opening part that is installable to a nozzle that performs suction and discharge of gas, and a narrow tube that possesses an opening, through which fluid inflow and outflow is possible by means of the suction and discharge of gas, that is narrower than the nozzle; a carrier in which a predetermined biological material is fixed or fixable in a plurality of different positions that are determined beforehand that are distinguishable from the exterior, and has a size or a shape that is able to pass through the opening; and an enclosing section provided on the tip form vessel that encloses the carrier within the narrow tube in a state where it is able to make contact with the fluid that has flown into the narrow tube from the opening.

摘要翻译： 生物材料固定载体包封尖端，生物材料固定载体处理装置及其处理方法。 目的是消除用于将载体储存和保持在尖端形状容器中的附着控制和抽吸控制，以简化复杂的反应过程，并且使生物材料固定载体的处理由于小规模化而容易地执行 设备配置。 生物材料固定载体包封尖端包括：尖端形状容器，其具有可安装到执行气体的抽吸和排出的喷嘴的安装开口部分和具有开口的窄管，通过该狭窄管可以通过该开口流体流出和流出 气体的吸入和排出装置，比喷嘴窄; 其中预定生物材料固定或固定在预先确定的与外部可区分的多个不同位置的载体，并且具有能够穿过开口的尺寸或形状; 以及设置在尖端形式容器上的封闭部分，其在能够与从开口流入细管的流体接触的状态下将载体包围在窄管内。

公开(公告)号：USD565192S1

公开(公告)日：2008-03-25

申请号：US29277777

申请日：2007-03-09

申请人： Hideji Tajima

设计人： Hideji Tajima