公开(公告)号：US5676971A

公开(公告)日：1997-10-14

申请号：US433803

申请日：1995-05-03

申请人： Hiroshi Yoshioka ,  Hiroshi Goto

发明人： Hiroshi Yoshioka ,  Hiroshi Goto

IPC分类号： A61K9/127 ,  A61K38/16 ,  A61K47/34 ,  A61P7/08 ,  B01J13/02 ,  A61K35/18 ,  B01J13/22

CPC分类号： A61K9/1271 ,  A61K9/1272 ,  Y10S514/832 ,  Y10T428/2984

摘要： Agents for inhibiting adsorption of proteins on the liposome surface and liposomes which are agglutination-free by binding said inhibiting agent on the surface are disclosed. The above-mentioned inhibiting agents comprise a hydrophobic moiety and a hydrophilic macromolecular chain moiety. Adsorption of plasma proteins on the liposomes is inhibited due to the hydrophilic moiety exposed on the liposome surface with a result that agglutination of the liposomes in plasma is prevented. Therefore, there is no danger of embolism in blood vessels inhibiting blood flow when the liposomes are introduced into the living body. Accordingly, the liposomes are especially highly useful as artificial erythrocytes for which a large dose of liposomes is needed for administration. Moreover, when liposomes are introduced into the living body, antibody protein (immunoglobulin) to the liposome which is an antigen will be adsorbed on the liposome to produce foreign body recognition in the phagocytes (macrophage) with a result that the liposome will be included in the macrophage and disappear within a short period of time. Thus, inhibition of the protein adsorption on liposome can delay disappearance of the liposome in plasma. In addition, a method for preparing the above-described liposomes is disclosed.

摘要翻译： 公开了通过在表面上结合所述抑制剂来抑制脂质体表面上的蛋白质吸附和不凝集的脂质体的试剂。 上述抑制剂包含疏水部分和亲水性大分子链部分。 血浆蛋白在脂质体上的吸附由于在脂质体表面上暴露的亲水部分而受到抑制，从而阻止了血浆中脂质体的凝集。 因此，当将脂质体引入生物体时，血管阻塞血栓的危险不存在。 因此，脂质体特别高度用作需要大剂量脂质体用于给药的人造红细胞。 此外，当将脂质体引入生物体中时，作为抗原的脂质体的抗体蛋白质（免疫球蛋白）将被吸附在脂质体上，以在吞噬细胞（巨噬细胞）中产生异物识别，结果将脂质体包含在 巨噬细胞在短时间内消失。 因此，抑制脂质体上的蛋白质吸附可以延迟脂质体在血浆中的消失。 此外，公开了制备上述脂质体的方法。

公开(公告)号：US5593622A

公开(公告)日：1997-01-14

申请号：US460714

申请日：1995-06-02

申请人： Hiroshi Yoshioka ,  Hiroshi Goto

发明人： Hiroshi Yoshioka ,  Hiroshi Goto

IPC分类号： A61K9/127 ,  A61K38/16 ,  A61K47/34 ,  A61P7/08 ,  B01J13/02 ,  B01J13/22

CPC分类号： A61K9/1271 ,  A61K9/1272 ,  Y10S514/832 ,  Y10T428/2984

摘要： Agents for inhibiting adsorption of proteins on the liposome surface and liposomes which are agglutination-free by binding said inhibiting agent on the surface are disclosed. The above-mentioned inhibiting agents comprise a hydrophobic moiety and a hydrophilic macromolecular chain moiety. Adsorption of plasma proteins on the liposomes is inhibited due to the hydrophilic moiety exposed on the liposome surface with a result that agglutination of the liposomes in plasma is prevented. Therefore, there is no danger of embolism in blood vessels inhibiting blood flow when the liposomes are introduced into the living body. Accordingly, the liposomes are especially highly useful as artificial erythrocytes for which a large dose of liposomes is needed for administration.Moreover, when liposomes are introduced into the living body, antibody protein (immunoglobulin) to the liposome which is an antigen will be adsorbed on the liposome to produce foreign body recognition in the phagocytes (macro-phage) with a result that the liposome will be included in the macrophage and disappear within a short period of time. Thus, inhibition of the protein adsorption on liposome can delay disappearance of the liposome in plasma.In addition, a method for preparing the above-described liposomes is disclosed.

摘要翻译： 公开了通过在表面上结合所述抑制剂来抑制脂质体表面上的蛋白质吸附和不凝集的脂质体的试剂。 上述抑制剂包含疏水部分和亲水性大分子链部分。 血浆蛋白在脂质体上的吸附由于在脂质体表面上暴露的亲水部分而受到抑制，从而阻止了血浆中脂质体的凝集。 因此，当将脂质体引入生物体时，血管阻塞血栓的危险不存在。 因此，脂质体特别高度用作需要大剂量脂质体用于给药的人造红细胞。 此外，当将脂质体引入生物体时，作为抗原的脂质体的抗体蛋白质（免疫球蛋白）将被吸附在脂质体上，以在吞噬细胞（大噬菌体）中产生异物识别，结果使脂质体为 包括在巨噬细胞中，并在短时间内消失。 因此，抑制脂质体上的蛋白质吸附可以延迟脂质体在血浆中的消失。 此外，公开了制备上述脂质体的方法。

公开(公告)号：US5541737A

公开(公告)日：1996-07-30

申请号：US162323

申请日：1993-12-07

申请人： Masaki Oguro ,  Hiroshi Yoshioka ,  Teruhiko Kori ,  Ken Iizuki

发明人： Masaki Oguro ,  Hiroshi Yoshioka ,  Teruhiko Kori ,  Ken Iizuki

IPC分类号： G11B27/10 ,  G11B5/008 ,  G11B15/087 ,  G11B15/18 ,  G11B23/087 ,  G11B27/032 ,  G11B27/036 ,  G11B27/11 ,  G11B27/28 ,  G11B27/30 ,  H04N5/782

CPC分类号： G11B15/087 ,  G11B15/1875 ,  G11B23/08714 ,  G11B27/036 ,  G11B27/11 ,  G11B27/3063 ,  G11B5/00878 ,  G11B2220/655 ,  G11B2220/90 ,  G11B27/032

摘要： Apparatus and method for recording in selectable recording modes, track number data and information signals in recording tracks on a recording medium, in which the track number of a track in which an information signal is recorded is determined by utilizing a ratio of a track pitch produced when a first recording mode is selected and a track pitch produced when a second recording mode is selected.

摘要翻译： 在可记录模式下记录轨道号数据和信息信号的装置和方法，其中记录信息记录的轨迹的轨道号通过利用产生的轨道间距的比来确定， 当选择第一记录模式并且当选择第二记录模式时产生轨道间距。

公开(公告)号：US5508365A

公开(公告)日：1996-04-16

申请号：US290126

申请日：1994-08-15

申请人： Kazuyoshi Fuse ,  Hiroshi Yoshioka

发明人： Kazuyoshi Fuse ,  Hiroshi Yoshioka

IPC分类号： C08F2/20 ,  C08F14/06

CPC分类号： C08F14/06

摘要： Disclosed is a method of producing a vinyl chloride resin which comprises subjecting a monomer selected from the group consisting of vinyl chloride and a monomer mixture containing vinyl chloride, as a major component, and at least one ethylenically unsaturated monomer copolymerized therewith as a minor component to polymerization reaction in the presence of(a) a pentaerythritol or dipentaerythritol fatty acid ester or(b) a pentaerythritol or dipentaerythritol fatty acid ester and a glycerol fatty acid ester.

摘要翻译： 公开了一种氯乙烯树脂的制造方法，其特征在于，将选自氯乙烯的单体和含有氯乙烯的单体混合物作为主要成分，和至少一种与其共聚的烯键式不饱和单体作为次要成分 在（a）季戊四醇或二季戊四醇脂肪酸酯的存在下进行聚合反应，或（b）季戊四醇或二季戊四醇脂肪酸酯和甘油脂肪酸酯。

公开(公告)号：US5426154A

公开(公告)日：1995-06-20

申请号：US762280

申请日：1991-09-19

申请人： Masato Mikami ,  Yuichi Mori ,  Hiroshi Yoshioka

发明人： Masato Mikami ,  Yuichi Mori ,  Hiroshi Yoshioka

IPC分类号： C08F259/04 ,  C08F265/10 ,  C08F267/10

CPC分类号： C08F259/04

摘要： This invention provides thermally reversible graft copolymer comprising a vinyl polymer graft-polymerized to a polymer of N-substituted acrylamide or methacrylamide derivatives.

摘要翻译： 本发明提供了包含接枝聚合成N-取代的丙烯酰胺或甲基丙烯酰胺衍生物的聚合物的乙烯基聚合物的热可逆接枝共聚物。

公开(公告)号：US5391591A

公开(公告)日：1995-02-21

申请号：US76905

申请日：1993-06-15

申请人： Toru Kawaguchi ,  Ichiro Ando ,  Nobuyuki Toyoshima ,  Yasushi Yamamoto ,  Hiroshi Yoshioka ,  Toshio Yamazaki

发明人： Toru Kawaguchi ,  Ichiro Ando ,  Nobuyuki Toyoshima ,  Yasushi Yamamoto ,  Hiroshi Yoshioka ,  Toshio Yamazaki

IPC分类号： C08F230/08 ,  G02B1/04 ,  C08F222/18 ,  C08F212/08 ,  C08F220/56

CPC分类号： G02B1/043 ,  C08F230/08

摘要： An ocular lens material comprising a copolymer prepared by polymerizing a monomer mixture comprising, as main components, (A) 15 to 40% by mole of a fluoroalkyl (silicon-containing alkyl) fumarate, (B) 10 to 50% by mole of a styrenic monomer, (C) 5 to 35% by mole of a hydrophilic monomer, and (D) 0.1 to 20% by mole of a crosslinkable monomer. The ocular lens material is excellent in all of transparency, oxygen permeability, mechanical strength and hardness. Further, the material is excellent in hydrophilic property in spite of its low water absorption.

摘要翻译： 一种眼透镜材料，其包含通过聚合单体混合物制备的共聚物，所述单体混合物包含作为主要成分的（A）15至40摩尔％的氟代烷基（含硅烷基）富马酸酯，（B）10至50摩尔％ 苯乙烯类单体，（C）5〜35摩尔％的亲水性单体，（D）0.1〜20摩尔％的交联性单体。 眼透镜材料透明性，透氧性，机械强度和硬度都是优异的。 此外，该材料的亲水性优异，尽管其吸水性低。

公开(公告)号：US5238545A

公开(公告)日：1993-08-24

申请号：US4882

申请日：1993-01-19

申请人： Hiroshi Yoshioka ,  Yuichi Mori

发明人： Hiroshi Yoshioka ,  Yuichi Mori

IPC分类号： B01D57/02 ,  G01N27/447

CPC分类号： G01N27/44747 ,  B01D57/02

摘要： An electrophoretic gel comprising at least one crosslinked temperature-responsive polymeric compound having an LCST is disclosed. A method of separating and recovering substances involves conducting the electrophoresis of a sample containing substances to be separated using the electrophoretic gel at a temperature below the LCST, excising each portion of the gel containing the substance to be separated and raising the temperature of the excised portion to a temperature above the LCST to shrink the excised portion to recover the substances.

摘要翻译： 公开了一种包含至少一种具有LCST的交联温度响应性聚合物的电泳凝胶。 分离和回收物质的方法包括在低于LCST的温度下使用电泳凝胶进行含有待分离物质的样品的电泳，切除含有待分离物质的凝胶的每一部分，并提高切除部分的温度 达到高于LCST的温度以收缩切除的部分以回收物质。

公开(公告)号：USD332266S

公开(公告)日：1993-01-05

申请号：US424562

申请日：1989-10-20

申请人： Shingo Iwai ,  Hiroshi Yoshioka

设计人： Shingo Iwai ,  Hiroshi Yoshioka

公开(公告)号：US5164057A

公开(公告)日：1992-11-17

申请号：US762272

申请日：1991-09-19

申请人： Yuichi Mori ,  Masato Mikami ,  Hiroshi Yoshioka

发明人： Yuichi Mori ,  Masato Mikami ,  Hiroshi Yoshioka

IPC分类号： G01N27/447

CPC分类号： G01N27/44747

摘要： An electrophoretic matrix comprised of at least one water-insolubilized, temperature-responsive polymeric compound having an LCST is disclosed. The electrophoretic matrix can change its hydrophilic/hydrophobic property by changing temperature. A method of using the electrophoretic matrix involves charging a sample onto the matrix and carrying out electrophoresis at a temperature above or below the LCST of the polymeric compound.

摘要翻译： 公开了由至少一种具有LCST的不溶于水的温度敏感的聚合物组成的电泳基质。 电泳基质可以通过改变温度来改变其亲水/疏水性质。 使用电泳基质的方法包括将样品装入基质并在高于或低于聚合物化合物的LCST的温度下进行电泳。

公开(公告)号：US5032636A

公开(公告)日：1991-07-16

申请号：US480329

申请日：1990-02-13

申请人： Ichiro Ono ,  Hiroshi Yoshioka

发明人： Ichiro Ono ,  Hiroshi Yoshioka

IPC分类号： C07F7/18 ,  C08K5/5419

CPC分类号： C08K5/5419 ,  C07F7/182

摘要： Organosilicon compounds of a novel class are disclosed including .alpha.,.omega.-bis(alkoxy silyl)-substituted alkane compounds represented by the general formula(RO).sub.m (CH.sub.3).sub.3-m Si--CH.sub.2).sub.n Si(CH.sub.3).sub.3-m (OR).sub.m,in which R is a monovalent hydrocarbon group having 1 to 4 carbon atoms, e.g., methyl and ethyl, the subscript n is a positive integer in the range from 10 to 18 and the subscript m is 1, 2 or 3. The compound is useful as an additive in various kinds of synthetic resin-based compositions for the purpose of improving the properties such as flexibility, weatherability, cold resistance and mechanical strengths.

摘要翻译： 公开了一类新的有机硅化合物，其包括由通式（RO）m（CH 3）3-mSi-CH 2）n Si（CH 3）3-m（OR）表示的α，ω-双（烷氧基甲硅烷基）取代的烷烃化合物， m，其中R为具有1至4个碳原子的一价烃基，例如甲基和乙基，下标n为10至18的正整数，下标m为1,2或3.化合物 可用作各种合成树脂基组合物中的添加剂，用于改善柔软性，耐候性，耐寒性和机械强度等性能。