公开(公告)号：US08500800B2

公开(公告)日：2013-08-06

申请号：US12563930

申请日：2009-09-21

Applicant: Francesco Maisano ,  Eran Miller ,  Oz Cabiri ,  Yaron Herman ,  Yoseph Weitzman ,  Yossi Gross

Inventor： Francesco Maisano ,  Eran Miller ,  Oz Cabiri ,  Yaron Herman ,  Yoseph Weitzman ,  Yossi Gross

IPC: A61F2/24

CPC classification number: A61F2/2466 ,  A61B17/0401 ,  A61B17/122 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61F2/2457 ,  A61F2/2487 ,  A61F2250/0007

Abstract: Apparatus for use with at least one leaflet-engaging element, the apparatus including a delivery tool which includes an inner shaft, a surrounding shaft, and at least one leaflet-engaging element holder coupled to a portion of the surrounding shaft, the leaflet-engaging-element holder being shaped to define at least one coupling site for reversibly coupling the leaflet-engaging element to the tool. The surrounding shaft surrounds a portion of the inner shaft and is slidable along the inner shaft so as to position the leaflet-engaging holder in a vicinity of at least one leaflet of an atrioventricular valve of a patient. A distal end of the inner shaft is advanceable between leaflets of the atrioventricular valve and toward a tissue site of a ventricle of the patient. Other applications are also described.

Abstract translation: 用于与至少一个传单接合元件一起使用的设备，该设备包括一个输送工具，该输送工具包括一个内轴，一个围绕的轴，以及至少一个联接到周围轴的一部分的传单接合元件保持架， - 元件保持器成形为限定至少一个联接位置，用于将传单接合元件可逆地联接到工具。 周围的轴围绕内轴的一部分并且可沿着内轴滑动，以将传单接合的保持器定位在病人的房室瓣的至少一个小叶附近。 内轴的远端可以在房室瓣的小叶之间并朝向患者的心室的组织部位前进。 还描述了其它应用。

公开(公告)号：US20130190691A1

公开(公告)日：2013-07-25

申请号：US13521181

申请日：2011-01-19

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M5/145

CPC classification number: A61M5/14566 ,  A61M5/1452 ,  A61M5/1456 ,  A61M5/2425 ,  A61M2005/14506

Abstract: A cartridge interface assembly (80) characterised by a driving plunger (82) including an outer shaft (84), and a driver (86) including an inner shaft (88) movable telescopically with respect to the outer shaft (84), wherein rotation of the driver (86) causes the driving plunger (82) to advance in a direction away from the driver (86), and wherein the cartridge interface assembly (80) is inserted in a cartridge (22) in which a plunger (24) is slidingly disposed, and rotation of the driver (86) causes the driving plunger (82) to advance distally in the cartridge (22) until abutting against the plunger (24).

Abstract translation: 一种盒式接口组件（80），其特征在于包括外轴（84）的驱动柱塞（82）和包括相对于外轴（84）可伸缩地移动的内轴（88）的驱动器（86），其中旋转 驱动器（86）使得驱动柱塞（82）沿远离驱动器（86）的方向前进，并且其中盒式接口组件（80）插入到其中柱塞（24）的盒（22）中， 滑动地设置，并且驱动器（86）的旋转导致驱动柱塞（82）在盒（22）中向远侧前进直到抵靠柱塞（24）。

公开(公告)号：US20120283757A1

公开(公告)日：2012-11-08

申请号：US13504870

申请日：2010-10-28

Applicant: Eran Miller ,  Oz Cabiri

Inventor： Eran Miller ,  Oz Cabiri

IPC: A61B17/03

CPC classification number: A61F2/2445 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0427 ,  A61B2017/0441 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2466

Abstract: Apparatus for use with an implant configured to be coupled to cardiac tissue of a patient, the apparatus including: a tissue anchor including: a distal tissue coupling element configured to couple the tissue anchor to the cardiac tissue of the patient, and a proximal implant-receiving element configured to receive at least a portion of the implant and facilitate coupling of the implant to the tissue anchor. The proximal implant-receiving element includes an implant-restraining element coupled to a portion of the implant-receiving element, the implant-restraining element being configured to restrain the implant from separating from the implant-receiving element. Other applications are also described.

Abstract translation: 一种用于与被配置成与患者的心脏组织连接的植入物的植入物的装置，所述装置包括：组织锚固件，其包括：远端组织连接元件，构造成将组织锚固件耦合到患者的心脏组织， 所述接收元件被配置为接收所述植入物的至少一部分并促进所述植入物与所述组织锚固件的联接。 近端植入物接收元件包括耦合到植入物接收元件的一部分的植入物限制元件，植入物限制元件被配置为限制植入物与植入物接收元件分离。 还描述了其它应用。

公开(公告)号：US08241351B2

公开(公告)日：2012-08-14

申请号：US12341960

申请日：2008-12-22

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61B17/068 ,  A61B17/072 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0649 ,  A61F2/2448 ,  A61F2/2466 ,  A61F2250/0004

Abstract: Apparatus is provided that is configured to be implanted in a body of a subject, comprising an implant structure having first and second portions thereof, a spool coupled to the implant structure in a vicinity of the first portion thereof, and a flexible member coupled at a first end thereof to the spool, and not attached at a second end thereof to the spool. The flexible member, in response to rotation of the spool in a first direction thereof, is configured to be wound around the spool, and, responsively, to pull the second end of the flexible member toward the first end of the implant structure, and responsively to draw the first and second portions of the implant structure toward each other. Other embodiments are also described.

Abstract translation: 提供了被配置为植入到受试者的身体中的装置，包括植入结构，其具有第一和第二部分，在其第一部分附近与所述植入物结构相连接的线轴， 其第一端连接到卷轴，并且在其第二端处未连接到卷轴。 响应于卷轴在其第一方向上的旋转，柔性构件被构造成围绕卷轴缠绕，并且响应地将柔性构件的第二端拉向植入物结构的第一端，并且响应地 以将植入物结构的第一和第二部分彼此拉出。 还描述了其它实施例。

公开(公告)号：US08152779B2

公开(公告)日：2012-04-10

申请号：US12345818

申请日：2008-12-30

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M5/31 ,  A61M5/20

CPC classification number: A61M5/14248 ,  A61M2005/14252

Abstract: A needle assembly adapted for fluid communication with a vial containing a substance to be delivered to a subject, the needle assembly including a needle held in a needle holder, the needle holder confined to move in a housing, and an activation mechanism for activating delivery of the substance through the needle, the activation mechanism including a safety latch that initially impedes movement of the needle holder, wherein when the safety latch is placed on the subject, the safety latch moves to a position that permits moving the needle holder to cause the needle to protrude outwards of the housing to pierce the subject to allow administration of the substance to the subject.

Abstract translation: 一种针组件，其适于与包含要递送到被检体的物质的小瓶流体连通，所述针组件包括保持在针保持器中的针，所述针保持器限定在壳体中移动，以及用于激活输送的活动机构 所述物质通过所述针，所述致动机构包括最初阻止所述针保持器的运动的安全闩锁，其中当所述安全闩锁被放置在所述被检体上时，所述安全闩锁移动到允许移动所述针架以使所述针头 突出到外壳的外面以刺穿受试者，以允许物质向受试者施用。

公开(公告)号：US20120046604A1

公开(公告)日：2012-02-23

申请号：US12860895

申请日：2010-08-22

Applicant: Oz Cabiri ,  Asnat Raziel

Inventor： Oz Cabiri ,  Asnat Raziel

IPC: A61M1/00

CPC classification number: A61B17/30 ,  A61B17/068 ,  A61B17/072 ,  A61B2017/00561 ,  A61B2017/00818 ,  A61B2017/0648 ,  A61B2017/306

Abstract: A tissue suction device including a tissue retracting element including a pair of tissue contacting surfaces separated from each other by a gap, the tissue contacting surfaces having a round rim around their edges, and a suction conduit having an opening proximal to the tissue contacting surfaces and in fluid communication with the gap, the tissue retracting element having a mode of operation wherein suction applied through the opening sucks tissue adjacent the tissue retracting element so that the tissue is drawn into the gap around the rim towards the tissue contacting surfaces.

Abstract translation: 一种组织抽吸装置，包括一组织缩回元件，该组织缩回元件包括通过间隙彼此分开的一对组织接触表面，所述组织接触表面具有围绕其边缘的圆形边缘，以及具有靠近组织接触表面的开口的抽吸管道， 与间隙流体连通的组织缩回元件具有操作模式，其中通过开口施加的抽吸吸附组织收缩元件附近的组织，使得组织被拉入围绕边缘的间隙朝向组织接触表面。

公开(公告)号：US20110218401A1

公开(公告)日：2011-09-08

申请号：US13111313

申请日：2011-05-19

Applicant: Oz Cabiri ,  Yossi Gross ,  Boris Degtiar ,  Eran Shor

Inventor： Oz Cabiri ,  Yossi Gross ,  Boris Degtiar ,  Eran Shor

IPC: A61B1/00

CPC classification number: A61B1/00

Abstract: An apparatus for use with a biologically-compatible-fluid pressure source, the apparatus includes an elongate carrier, adapted to be inserted through a proximal opening of a body lumen, and a piston head coupled to a distal portion of the carrier. The piston head is adapted to form a pressure seal with a wall of the lumen after the carrier has been inserted into the lumen, and to be advanced distally through the body lumen in response to pressure from the fluid pressure source. The apparatus is configured to facilitate distal advancement of the piston head by facilitating passage of fluid out of the lumen from a site within the lumen distal to the piston head.

Abstract translation: 一种用于与生物相​​容的流体压力源一起使用的装置，该装置包括一个细长的载体，适于插入通过体腔的近端开口，以及活塞头，其联接到载体的远端部分。 活塞头适于在载体已经插入内腔之后与内腔的壁形成压力密封，并且响应于来自流体压力源的压力而向远侧远端推进通过体腔。 该装置被配置为通过促使流体从内腔远离活塞头的内部位置流出管腔来促进活塞头的远端前进。

公开(公告)号：US20110166509A1

公开(公告)日：2011-07-07

申请号：US13063236

申请日：2009-09-14

Applicant: Yossi Gross ,  Oz Cabiri

Inventor： Yossi Gross ,  Oz Cabiri

IPC: A61M5/42 ,  A61M5/31

CPC classification number: A61M5/425 ,  A61M5/31511 ,  A61M37/0015 ,  A61M37/0069 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

Abstract: Apparatus for use with tissue (22) of a subject, including a substance (24) configured to be injected into the tissue, and first and second tissue-squeezing surfaces (20) configured to be placed on first and second sides of the tissue, to exert pressure on the tissue by being moved toward each other in response to a squeezing force (F), and to facilitate injection of the substance into the tissue by releasing the substance in response to application of the squeezing force.

Abstract translation: 用于受试者的组织（22）的装置，包括被配置为注入组织的物质（24）以及被配置为放置在组织的第一和第二侧上的第一和第二组织挤压表面（20） 通过响应于挤压力（F）而朝向彼此移动而对组织施加压力，并且通过响应于挤压力的释放释放物质，便于将物质注入组织。

公开(公告)号：US20110106247A1

公开(公告)日：2011-05-05

申请号：US12608316

申请日：2009-10-29

Applicant: Eran MILLER ,  Oz Cabiri

Inventor： Eran MILLER ,  Oz Cabiri

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0427 ,  A61B2017/0441 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61F2/2466

Abstract: Apparatus is provided for use with an implant, the apparatus including a tissue anchor, which comprises a distal tissue coupling element, which is configured to penetrate cardiac tissue, and a proximal implant-penetrating element configured to penetrate the implant. The proximal implant-penetrating element is shaped so as to define a passage therethrough, which passage has at least two openings that are within 1 mm of a proximal end of the implant-penetrating element. The apparatus also comprises a cord configured to be removably passed through the passage. Other applications of the present invention are also described.

Abstract translation: 提供了一种用于植入物的装置，该装置包括组织锚固件，其包括构造成穿透心脏组织的远侧组织连接元件以及被配置为穿透植入物的近端植入物穿透元件。 近端植入物穿透元件被成形为限定穿过其中的通道，该通道具有至少两个在植入物穿透元件的近端的1mm内的开口。 该装置还包括被配置为可移除地穿过通道的绳索。 还描述了本发明的其它应用。

公开(公告)号：US20100280603A1

公开(公告)日：2010-11-04

申请号：US12563930

申请日：2009-09-21

Applicant: Francesco Maisano ,  Eran Miller ,  Oz Cabiri ,  Yaron Herman ,  Yoseph Weitzman ,  Yossi Gross

Inventor： Francesco Maisano ,  Eran Miller ,  Oz Cabiri ,  Yaron Herman ,  Yoseph Weitzman ,  Yossi Gross

IPC: A61F2/24

CPC classification number: A61F2/2466 ,  A61B17/0401 ,  A61B17/122 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61F2/2457 ,  A61F2/2487 ,  A61F2250/0007

Abstract: A method is provided, including advancing a distal end of an inner shall of a delivery tool between leaflets of an atrioventricular valve, of a patient and into a ventricle of the patient. The method further includes, while maintaining the distal end of the inner shaft in place and within the ventricle, proximally withdrawing a surrounding shaft of the delivery tool with respect to the distal end of the inner shaft and toward the leaflets. This surrounding shaft surrounds a portion of the inner shaft. The method additionally includes using the surrounding shaft to engage at least one of the leaflets with at least one leaflet-engaging element. After engaging, the distal end of the inner shaft is proximally withdrawn from within the ventricle. Other applications are also described.

Abstract translation: 提供了一种方法，包括将患者的房室瓣的小叶之间的输送工具的内部的远端推进到患者的心室中。 该方法还包括在将内轴的远端保持在适当位置并且在心室内的同时，相对于内轴的远端朝向传单向近端地抽出输送工具的周围轴。 该周围的轴围绕内轴的一部分。 该方法还包括使用周围的轴将至少一个传单与至少一个传单接合元件接合。 在接合之后，内轴的远端从心室内向近端抽出。 还描述了其它应用。