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91.发明申请公开(公告)号：US20090142387A1
公开(公告)日：2009-06-04
申请号：US12274378
申请日：2008-11-20
CPC分类号： G02B1/043
摘要： A method for inhibiting adhesion of bacteria to a surface of a biomedical device is disclosed. The method involves at least (a) incorporating one or more non-functionalized polymers having one or more hydrophilic moieties into an ophthalmic device that is a polymerization product of a comonomer mixture comprising: (i) a major amount of a non-silicone-containing hydrophilic monomer; and (ii) an end-terminal functionalized surfactant; and (b) inserting the ophthalmic device in the eye of a patient, wherein the at least one non-functionalized polymer migrates to the surface of the device in a sustained release manner to inhibit adhesion of bacteria to a surface of the biomedical device. Biomedical devices are also disclosed.
摘要翻译： 公开了一种抑制细菌对生物医学装置表面粘附的方法。 该方法至少包括（a）将一种或多种具有一个或多个亲水部分的非官能化聚合物掺入到作为共聚单体混合物的聚合产物的眼科装置中，所述共聚单体混合物包含：（i）主要量的非含硅氧烷 亲水单体; 和（ii）末端官能化表面活性剂; 和（b）将眼科装置插入患者的眼睛中，其中所述至少一种非官能化聚合物以持续释放的方式迁移到所述装置的表面，以抑制细菌粘附到所述生物医学装置的表面。 还公开了生物医学装置。
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公开(公告)号：US07402634B2
公开(公告)日：2008-07-22
申请号：US11173707
申请日：2005-07-01
IPC分类号： C08F14/18
CPC分类号： C08G65/337 , C08G61/12 , G02B1/043
摘要： The present invention provides copolymer having repeating units based on polyoxyalkylene radicals, polysiloxane radicals and perfluorocyclobutane radicals. The copolymers are useful as biomedical devices such as contact lenses or intraocular lenses.
摘要翻译： 本发明提供了基于聚氧化烯基，聚硅氧烷基和全氟环丁烷基的重复单元的共聚物。 该共聚物可用作生物医学装置如隐形眼镜或人工晶状体。
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公开(公告)号：US20080150177A1
公开(公告)日：2008-06-26
申请号：US11613360
申请日：2006-12-20
CPC分类号： B29D11/00125 , B29C59/14 , B29L2011/0041 , C08J7/123 , C08J2383/04
摘要： A method for treating a surface of a fluorinated silicone-containing ophthalmic device is provided, the method comprising plasma treating the fluorinated silicone-containing ophthalmic device with a hydrogen-containing atmosphere in the presence of an oxidizing source thereby increasing the wettability and/or biocompatibility of the device.
摘要翻译： 提供了一种用于处理含氟硅氧烷的眼科装置的表面的方法，该方法包括在氧化源的存在下用含氢气体等离子体处理含氟聚硅氧烷的眼科装置，从而增加润湿性和/或生物相容性 的设备。
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公开(公告)号：US20080076898A1
公开(公告)日：2008-03-27
申请号：US11840650
申请日：2007-08-17
申请人： Joseph C. Salamone , Jay F. Kunzler
发明人： Joseph C. Salamone , Jay F. Kunzler
CPC分类号： C08G77/20 , C08G77/30 , G02B1/043 , C08L51/085 , C08L83/10
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain hydrophilic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerizable hydrophilic siloxanyl monomers.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地说，本发明涉及能够聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些亲水性单体。 聚合物组合物包含可聚合的亲水硅氧烷基单体。
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公开(公告)号：US20080004413A1
公开(公告)日：2008-01-03
申请号：US11480111
申请日：2006-06-30
申请人： Derek Schorzman , Jay Kunzler , Joseph C. Salamone
发明人： Derek Schorzman , Jay Kunzler , Joseph C. Salamone
CPC分类号： C08G77/38 , A61L27/18 , C08G77/388 , C08L83/06 , C08L83/04
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain carboxylic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerized carboxylic hydrophilic siloxanyl monomers.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地说，本发明涉及能够聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些羧酸单体。 聚合物组合物包含聚合的羧酸亲水硅氧烷基单体。
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96.发明申请公开(公告)号：US20080003259A1
公开(公告)日：2008-01-03
申请号：US11480243
申请日：2006-06-30
申请人： Joseph C. Salamone , Yu-Chin Lai , Weihong Lang , Wenyan Yan
发明人： Joseph C. Salamone , Yu-Chin Lai , Weihong Lang , Wenyan Yan
IPC分类号： A61F2/02
摘要： A medical device having an increased surface hydrophilicity comprises a coating polymer comprising units of a polymerizable hydrophilic compound that is attached to the surface of the medical device via the Michael addition reaction. The coating polymer can be applied to a medical device comprising a hydrogel material. The attachment of the coating polymer may be enhanced by increasing the population of the medical-device surface functional groups before contacting the medical device with the coating polymer.
摘要翻译： 具有增加的表面亲水性的医疗装置包括涂覆聚合物，其包含通过迈克尔加成反应附着到医疗装置的表面上的可聚合亲水性化合物的单元。 涂层聚合物可以应用于包含水凝胶材料的医疗装置。 涂层聚合物的附着可以通过在接触医疗器械与涂层聚合物之前增加医疗器械表面官能团的数量来增强。
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97.发明授权公开(公告)号：US07282178B2
公开(公告)日：2007-10-16
申请号：US11442789
申请日：2006-05-30
CPC分类号： C11D3/0078 , C11D1/008 , C11D1/72 , C11D1/8255 , C11D3/3707 , C11D3/3723 , C11D11/0041
摘要： This invention is directed to an aqueous composition and methods for clean lipid deposits on contact lenses. In particular, a combination of non-ionic surfactants, branched and/or straight poly(ethylene oxide-propylene oxide) (PEO-PPO) block copolymers having HLB value greater than or equal to 18, with an additional straight poly(ethylene oxide-propylene oxide) (PEO-PPO) block copolymers having HLB value less than or equal to 15, has been found to improve the lipid cleaning properties of an aqueous composition for contact lenses and prevent the overgrowth of harmful bacteria, yeast and molds without adversely affecting the comfort or safety in terms of the level of toxicity to eye tissue.
摘要翻译： 本发明涉及一种水性组合物和用于在隐形眼镜上清洁脂质沉积的方法。 特别地，具有HLB值大于或等于18的非离子表面活性剂，支链和/或直链聚（环氧乙烷 - 环氧丙烷）（PEO-PPO）嵌段共聚物与另外的直链（环氧乙烷 - 环氧丙烷） 已经发现HLB值小于或等于15的环氧丙烷（PEO-PPO）嵌段共聚物可改善隐形眼镜水性组合物的脂质清洁性能并防止有害细菌，酵母和霉菌的过度生长而不会不利地影响 对眼组织的毒性水平的舒适度或安全性。
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98.发明授权公开(公告)号：US07276619B2
公开(公告)日：2007-10-02
申请号：US10801741
申请日：2004-03-16
IPC分类号： C07F7/02
CPC分类号： A61K31/80 , A61K31/695 , C07F7/089 , C07F7/20 , C08G77/34 , Y02P20/544
摘要： A process for the purification of a silicone oil or fluid using neat supercritical carbon dioxide or a supercritical carbon dioxide mixture extraction to produce vitreoretinal silicone tamponades. The subject process is an economical, highly effective, reproducible, contaminant-free method by which unreacted relatively low molecular weight cyclic siloxanes and oligomers are removed from relatively high molecular weight silicone oil or fluid.
摘要翻译： 使用纯超临界二氧化碳或超临界二氧化碳混合物萃取来纯化硅油或流体以产生玻璃体视丝素硅酮填塞物的方法。 本发明方法是经济的，高效的，可重复的，无污染的方法，通过该方法从相对高分子量的硅油或流体中除去未反应的相对低分子量的环状硅氧烷和低聚物。
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公开(公告)号：US07247270B2
公开(公告)日：2007-07-24
申请号：US11355143
申请日：2006-02-15
申请人： Zhenze Hu , Joseph C. Salamone , Dharmendra Jani
发明人： Zhenze Hu , Joseph C. Salamone , Dharmendra Jani
CPC分类号： C11D3/3707 , A61L12/142 , C11D3/0078 , C11D3/3773 , C11D3/3776
摘要： The present invention is directed to an ophthalmic solution for soft contact lenses for controlled release of polyethers into an eye's tear film. Polyether components of the subject solution are released from the soft contact lens material matrix over long time periods to produce longer lasting wetting performance, improved lubricity, improved end-of-the-day comfort and reduced feeling of dryness from wearing contact lenses. The present invention also includes the use of cationic polyelectrolytes for controlling the swelling of hydrogel contact lenses typically caused by the absorption of high concentrations of polyethers.
摘要翻译： 本发明涉及用于将聚醚控制释放到眼睛的泪液膜中的软性隐形眼镜的眼用溶液。 本发明溶液的聚醚组分长时间从软性隐形眼镜材料基质中释放出来，以产生更持久的润湿性能，改善的润滑性，改善了最终的舒适感和减少佩戴隐形眼镜的干燥感。 本发明还包括使用阳离子聚电解质来控制通常由吸收高浓度聚醚引起的水凝胶隐形眼镜的溶胀。
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100.发明申请公开(公告)号：US20070160643A1
公开(公告)日：2007-07-12
申请号：US11611508
申请日：2006-12-15
CPC分类号： C08G77/388 , G02B1/043
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic random copolymers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized siloxane prepolymer containing pendant cationic and polymerizable groups.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子无规共聚物。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含聚合的含有阳离子和可聚合基团的聚硅氧烷预聚物。
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