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公开(公告)号：US07667000B2
公开(公告)日：2010-02-23
申请号：US11670118
申请日：2007-02-01
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： C07K16/00
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor16”的新的人细胞因子受体。
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公开(公告)号：USRE41129E1
公开(公告)日：2010-02-16
申请号：US11346580
申请日：2006-02-02
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 本发明涉及zalpha11配体多核苷酸和多肽分子。 zalpha11配体是一种新型细胞因子。 多肽可用于在体外和体内刺激造血细胞的增殖和/或发育的方法中。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07638286B2
公开(公告)日：2009-12-29
申请号：US11537835
申请日：2006-10-02
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07619071B2
公开(公告)日：2009-11-17
申请号：US11537910
申请日：2006-10-02
CPC分类号： C07K14/7155 , C07K14/7156 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor14”的新的人细胞因子受体。
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公开(公告)号：US07612191B2
公开(公告)日：2009-11-03
申请号：US11537892
申请日：2006-10-02
IPC分类号： C07H21/00
CPC分类号： C07K14/7155 , C07K14/7156 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor14”的新的人细胞因子受体。
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公开(公告)号：US07579441B2
公开(公告)日：2009-08-25
申请号：US11551811
申请日：2006-10-23
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US07563568B2
公开(公告)日：2009-07-21
申请号：US10806294
申请日：2004-03-22
IPC分类号： C12Q1/68
CPC分类号： C07K16/24 , A61K38/00 , A61K39/00 , C07K14/54 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to ZCYTO18 polynucleotide and polypeptide molecules. The ZCYTO18 is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 本发明涉及ZCYTO18多核苷酸和多肽分子。 ZCYTO18是一种新型细胞因子。 多肽可用于在体外和体内刺激造血细胞的增殖和/或发育的方法中。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07517958B2
公开(公告)日：2009-04-14
申请号：US11537916
申请日：2006-10-02
IPC分类号： C07K14/00
CPC分类号： C07K14/7155 , C07K14/7156 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor14”的新的人细胞因子受体。
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公开(公告)号：US07122342B1
公开(公告)日：2006-10-17
申请号：US09371333
申请日：1999-08-10
申请人： Wen-feng Xu , Scott R. Presnell , David P. Yee , Donald C. Foster
发明人： Wen-feng Xu , Scott R. Presnell , David P. Yee , Donald C. Foster
IPC分类号： C12N15/12
CPC分类号： C07K14/705
摘要： The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.
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公开(公告)号：US06902729B2
公开(公告)日：2005-06-07
申请号：US10358619
申请日：2003-02-04
申请人： Scott R. Presnell , Andrew L. Feldhaus , Zeren Gao
发明人： Scott R. Presnell , Andrew L. Feldhaus , Zeren Gao
CPC分类号： C07K14/56 , A61K38/00 , Y10S977/918 , Y10S977/927
摘要： Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. The present invention provides a new form of murine interferon-α, which has applications in diagnosis and therapy.
摘要翻译： 干扰素代表了一类重要的生物制药产品，在治疗各种医疗条件方面具有良好的记录，包括治疗某些自身免疫性疾病，治疗特定癌症，以及增强针对感染因子的免疫应答。 本发明提供了一种新型的鼠干扰素-α，其在诊断和治疗中具有应用。
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