Abstract:
A fulfillment management system includes a database operable to store product availability information associated with at least one product. The fulfillment management system also includes one or more processors collectively operable to receive at least one component available-to-promise (ATP) request. Each component ATP request corresponds to a particular ATP request line-item for a desired product. The one or more processors are also operable to retrieve at least a portion of the product availability information associated with the desired product from the database for each component ATP request, determine an ATP response for each component ATP request using the retrieved product availability information, generate a component quotation for each component ATP request according to the corresponding ATP response, and communicate the component quotation for consolidation with other component quotations.
Abstract:
Methods and compositions are provided for selecting drug targets in silico, that include the following steps performed in the order presented or an alternative order of partially or entirely at the same time: (a) identifying one or more essential or functionally important sequences from a model organism using pre-existing genomic and phenotypic data; (b) comparing sequences from (a) with a DNA or peptide sequence from a pathogen to store homologous sequences; (c) comparing sequences from the pathogen with the DNA or peptide sequence from a host organism to store those sequences absent in the host organism; and (d) comparing sequences from (b) and (c) to identify shared sequences, the shared sequences being a drug target. Additionally, identified drug targets are provided.
Abstract:
Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme cleavage activity compared to the unmodified enzyme. Activities associated with the modified DNA cleaving enzyme that can be modulated in different reaction conditions include at least one of: (a) non-sequence specific nicking activity; (b) cleaving the second strand of a duplex DNA at a preexisting nick site to produce a linear duplex with a single strand overhang; (c) non-sequence specific DNA cleavage; (d) cleaving DNA flanking a mismatch; and (e) cleavage at a cruciform structure in a DNA duplex.
Abstract:
A beverage dispensing apparatus includes a dispensing device, at least one valve that distributes a diluent, a concentrate pump that distributes concentrate, a support structure that supports the foregoing components and exterior cladding attached to the support structure. The exterior cladding provides the appearance of a real leaf tea brewer. The diluent valve and concentrate pump distribute the diluent and concentrate into the dispensing device to form a mixture to be dispensed therefrom. The diluent can be hot water and the apparatus further includes an air ejector device for eliminating air bubbles from the hot water prior to mixing. In addition, an improved sensor can accurately determine when the supply of concentrate is depleted.
Abstract:
A beverage dispensing apparatus includes a mixing chamber for mixing hot water, a beverage concentrate and cold water, as well as one or more additives. The hot water and cold water are supplied at a predetermined flow rate at a predetermined proportion, regardless of the pressure of the water supply. A water heater supplies the hot water within a specified pressure range and without significant entrapped air.
Abstract:
p38beta2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p38beta2 polypeptides and polynucleotides in the design of protocols for the treatment of central nervous system disorder such as senile dementia of the Alzheimer's type (SDAT), multiple sclerosis, cerebral malaria, stroke, head trauma and spinal cord injury; cardiovascular diseases such as restenosis and atherosclerosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma; and other such diseases or conditions associated with dysregulated or excess cytokines such as osteporosis, sepsis due to surgical or traumatic incident, chronic renal failure, AIDs, cachexia and autoimmune conditions such as lupus erthyromatosis, host graft rejection and graft versus host disease, among others, and diagnostic assays for such conditions.
Abstract:
An integrated radio frequency transceiver comprising a diversity receiver and transmitter capable of performing a self test operation to determine if the receiver and transmitter paths are properly operational. The diversity receiver includes two receiver paths, a first path for receiving radio communications having a permitted bandpass, and a second receiver path for receiving radio signals from other radio port channels in use to assist in constructing its own neighbor list.
Abstract:
A processor includes a memory management unit and a front end including a decoder. The decoder includes logic to receive a flush-on-commit (FoC) instruction to flush dirty data from a volatile cache to a persistent memory upon commitment of a store associated with the FoC instruction. The memory management unit includes logic to, based upon a flush-on-fail (FoF) mode, skip execution of the flush-on-commit instruction and to flush the dirty data from the volatile cache upon a subsequent FoF operation.
Abstract:
A system and methods for reliability management of virtual machines in a host system. The reliability of the host system is monitored and compared with a reliability threshold level for a virtual machine. If the reliability of the host system drops below the reliability threshold level, the virtual machine is migrated to another host system having an appropriate level of reliability.
Abstract:
A computer-implemented method for migrating replicated virtual machine disks may include 1) replicating a virtual machine disk from an initial data store at a primary site to an initial data store at a secondary site to create a replicated virtual machine disk, 2) identifying a request to migrate the virtual machine disk within the primary site, 3) pausing replication of the virtual machine disk and mirroring the virtual machine disk from the initial data store a subsequent data store at the primary site, mirroring the replicated virtual machine disk from the initial data store to a subsequent data store at the secondary site, and 4) upon mirroring, resuming replication of the virtual machine disk by replicating the virtual machine disk from the subsequent data store at the primary site to the subsequent data store at the secondary site. Various other methods, systems, and computer-readable media are also disclosed.