公开(公告)号：US20120101064A1

公开(公告)日：2012-04-26

申请号：US13266976

申请日：2010-04-30

Applicant: Steven Howard ,  Paul Neil Mortenson ,  Steven Douglas Hiscock ,  Alison Jo-Anne Woolford ,  Andrew James Woodhead ,  Gianni Chessari ,  Marc O'reilly ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Young Shin Cho ,  Fan Yang ,  Christine Hiu-Tung Chen ,  Christopher Thomas Brain ,  Bharat Lagu ,  Yaping Wang ,  Sunkyu Kim ,  John Grialdes ,  Michael Joseph Luzzio ,  Lawrence Blas Perez

Inventor： Steven Howard ,  Paul Neil Mortenson ,  Steven Douglas Hiscock ,  Alison Jo-Anne Woolford ,  Andrew James Woodhead ,  Gianni Chessari ,  Marc O'reilly ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Young Shin Cho ,  Fan Yang ,  Christine Hiu-Tung Chen ,  Christopher Thomas Brain ,  Bharat Lagu ,  Yaping Wang ,  Sunkyu Kim ,  John Grialdes ,  Michael Joseph Luzzio ,  Lawrence Blas Perez

IPC: A61K31/675 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/4545 ,  C07D413/06 ,  A61K31/5377 ,  C07D417/10 ,  A61K31/427 ,  C07D403/10 ,  A61K31/4178 ,  C07D409/10 ,  C07D401/06 ,  A61K31/4725 ,  A61K31/551 ,  C07D471/04 ,  A61K31/437 ,  C07F9/6561 ,  A61P35/00 ,  A61P35/02 ,  C07D401/14

CPC classification number: C07D471/04 ,  C07D233/22 ,  C07D233/24 ,  C07D235/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D487/04 ,  C07D519/00

Abstract: The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+—O− or CR3; Y is N, N+—O− or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.

Abstract translation: 本发明提供式（I）化合物及其盐，互变异构体，溶剂化物和N-氧化物; 其中Q是CH或N; X是N，N + -O-或CR 3; Y是N，N + -O-或CR3a; R1和R2独立地选自氢和权利要求中定义的各种取代基; 或R 1和R 2与它们所连接的原子一起连接以形成任选取代的4至7个成员的碳环或杂环芳族或非芳族环; R3选自氢和各种取代基; 并且R 3a选自氢和权利要求中定义的各种取代基。 还提供含有式（I）化合物，制备化合物的方法和化合物的医疗用途的药物组合物。 式（I）化合物具有作为CDK激酶抑制剂的活性，并且可用于治疗尤其是增殖性疾病如癌症。

公开(公告)号：US08013240B2

公开(公告)日：2011-09-06

申请号：US11566134

申请日：2006-12-01

Applicant: Stephen R. Forrest ,  Fan Yang ,  Barry P. Rand

Inventor： Stephen R. Forrest ,  Fan Yang ,  Barry P. Rand

IPC: H01L31/00

CPC classification number: H01L51/4246 ,  B82Y10/00 ,  H01L27/302 ,  H01L51/0046 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0078 ,  H01L51/4253 ,  Y02E10/549

Abstract: A photosensitive device includes a plurality of organic photoconductive materials disposed in a stack between a first electrode and a second electrode, including a first continuous layer of donor host material, a second continuous layer of acceptor host material, and at least one other organic photoconductive material disposed as a plurality of discontinuous islands between the first continuous layer and the second continuous layer. Each of these other photoconductive materials has an absorption spectra different from the donor host material and the acceptor host material. Preferably, each of the discontinuous islands consists essentially of a crystallite of the respective organic photoconductive material, and more preferably, the crystallites are nanocrystals.

Abstract translation: 感光装置包括多个有机光电导材料，其布置在第一电极和第二电极之间的堆叠中，包括施主主体材料的第一连续层，受主主体材料的第二连续层和至少一个其它有机光电导材料 被布置为在所述第一连续层和所述第二连续层之间的多个不连续岛。 这些其它光电导材料中的每一种具有与供体主体材料和受主主体材料不同的吸收光谱。 优选地，每个不连续岛基本上由相应有机光电导材料的微晶组成，更优选地，微晶是纳米晶体。

公开(公告)号：US20110114921A1

公开(公告)日：2011-05-19

申请号：US11483642

申请日：2006-07-11

Applicant: Fan Yang ,  Stephen R. Forrest

Inventor： Fan Yang ,  Stephen R. Forrest

IPC: H01L51/44 ,  H01L51/48 ,  H01L51/46

CPC classification number: H01L51/447 ,  H01L51/0053 ,  H01L51/0078 ,  H01L51/0096 ,  H01L51/424 ,  Y02E10/549

Abstract: An optoelectronic device and a method for fabricating the optoelectronic device includes a first electrode disposed on a substrate, an exposed surface of the first electrode having a root mean square roughness of at least 30 nm and a height variation of at least 200 nm, the first electrode being transparent. A conformal layer of a first organic semiconductor material is deposited onto the first electrode by organic vapor phase deposition, the first organic semiconductor material being a small molecule material. A layer of a second organic semiconductor material is deposited over the conformal layer. At least some of the layer of the second organic semiconductor material directly contacts the conformal layer. A second electrode is deposited over the layer of the second organic semiconductor material. The first organic semiconductor material is of a donor-type or an acceptor-type relative to the second organic semiconductor material, which is of the other material type.

Abstract translation: 光电子器件和制造光电器件的方法包括设置在衬底上的第一电极，第一电极的暴露表面具有至少30nm的均方根粗糙度和至少200nm的高度变化，第一电极的第一电极 电极透明。 第一有机半导体材料的共形层通过有机气相沉积沉积到第一电极上，第一有机半导体材料是小分子材料。 第二有机半导体材料层沉积在保形层上。 第二有机半导体材料的至少一些层直接接触共形层。 第二电极沉积在第二有机半导体材料的层上。 第一有机半导体材料是相对于第二有机半导体材料的施主型或受体型，其为另一种材料类型。

公开(公告)号：US20100222546A1

公开(公告)日：2010-09-02

申请号：US12312766

申请日：2007-11-28

Applicant: David Crich ,  Songpu Guo ,  Fan Yang ,  Kasinath Sana

Inventor： David Crich ,  Songpu Guo ,  Fan Yang ,  Kasinath Sana

IPC: C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

CPC classification number: C07K1/02 ,  C07K1/086 ,  C07K1/1075 ,  C07K1/1077 ,  C07K5/1013 ,  C07K7/06 ,  C07K14/4711

Abstract: The present invention relates to methods for ligation or derivatization of peptides, amino acids, and carbohydrates utilizing a chalcogen-based reactant, a peptide reactant, an amino acid reactant, a chalcogen-containing peptide reactant, a chalcogen-containing amino acid reactant, or a combination of two or more of the foregoing reactants substantially as described herein.

Abstract translation: 本发明涉及利用硫属元素反应物，肽反应物，氨基酸反应物，含硫属元素的肽反应物，含硫属元素的氨基酸反应物，或 基本上如本文所述的两种或更多种前述反应物的组合。

公开(公告)号：US20100162060A1

公开(公告)日：2010-06-24

申请号：US12337629

申请日：2008-12-18

Applicant: Sreejit Chakravarty ,  Narendra B. Devta-Prasa ,  Arun Gunda ,  Fan Yang

Inventor： Sreejit Chakravarty ,  Narendra B. Devta-Prasa ,  Arun Gunda ,  Fan Yang

IPC: G01R31/3177 ,  G06F11/25

CPC classification number: G01R31/318552

Abstract: A scan clock modifier, a method of providing a variable scan clock, an IC including a scan clock modifier and a library including a cell of a scan clock modifier. In one embodiment, the scan clock modifier includes: (1) logic circuitry configured to provide at least one selected clock signal based on a test scan clock signal and a first clock control signal, both of the test scan clock signal and the first clock control signal received from test equipment and (2) comparison logic configured to provide a scan clock signal based on the at least one selected clock signal and at least one other clock control signal received from the test equipment, wherein the first and the at least one other clock control signals are different clock control signals.

Abstract translation: 扫描时钟修改器，提供可变扫描时钟的方法，包括扫描时钟修改器的IC和包括扫描时钟修改器的单元的库。 在一个实施例中，扫描时钟修改器包括：（1）逻辑电路，被配置为基于测试扫描时钟信号和第一时钟控制信号提供至少一个选择的时钟信号，测试扫描时钟信号和第一时钟控制 从所述测试设备接收的信号和（2）配置成基于所述至少一个所选择的时钟信号和从所述测试设备接收的至少一个其它时钟控制信号提供扫描时钟信号的比较逻辑，其中所述第一和所述至少一个其他 时钟控制信号是不同的时钟控制信号。

公开(公告)号：US07625844B1

公开(公告)日：2009-12-01

申请号：US11404807

申请日：2006-04-17

Applicant: Fan Yang ,  Guang Yang

Inventor： Fan Yang ,  Guang Yang

IPC: C40B30/06

CPC classification number: C12Q1/18 ,  C40B30/06

Abstract: The instant invention provides a live labeling microorganism assay for screening a one-bead one-compound library to identify synthetic anti-adherent compounds for blocking biofilm formation. The compounds of libraries may be peptides, small molecules, nucleic acids, other types of molecules or a combination of the foregoing. The live labeling microorganisms are incubated with a one-bead one-compound library for a long period with fresh-labeled bacteria and nutrition replacement in regular intervals. Those beads without bacterial adhesion are transferred into nutritional agar for the culture. The true anti-adherent beads are isolated and the sequences of each isolated compound-bead are determined with sequencer. The anti-adherent compounds identified in this invention are proved to possess long-term effect of blocking bacterial adhesion and biofilm formation. Thus the instant invention provides a unique and powerful method to identify anti-adherent compounds from library more quickly and reliably than current state-of-the-art technology allows.

Abstract translation: 本发明提供了用于筛选单珠单一化合物文库以鉴定用于阻断生物膜形成的合成抗粘附化合物的活标记微生物测定。 文库的化合物可以是肽，小分子，核酸，其他类型的分子或前述的组合。 将活标记微生物与单珠一化合物文库长时间培养，并定期进行新鲜标记的细菌和营养替代。 没有细菌粘附的那些珠被转移到用于培养的营养琼脂中。 分离真实的抗粘附珠，并用测序仪测定每个分离的化合物珠的序列。 证明本发明中鉴定的抗粘连化合物具有阻止细菌粘附和生物膜形成的长期作用。 因此，本发明提供了一种独特而强大的方法，可以比目前最先进的技术允许的更快速可靠地鉴定来自文库的抗粘附化合物。

公开(公告)号：US20090222591A1

公开(公告)日：2009-09-03

申请号：US12039502

申请日：2008-02-28

Applicant: Fan Yang

Inventor： Fan Yang

IPC: G06F15/16

CPC classification number: H04W48/18 ,  H04W48/12 ,  H04W88/06

Abstract: A method and apparatus are disclosed according to which a programmable access selector comprising at least one defined characteristic and at least one defined method are applied with each other, wherein at least one access from among a plurality of available accesses is selected responsive to the application.

Abstract translation: 公开了一种方法和装置，根据该方法和装置，包括至少一个定义的特征和至少一个定义的方法的可编程访问选择器彼此应用，其中响应于该应用来选择来自多个可用访问中的至少一个访问。

公开(公告)号：US20090132959A1

公开(公告)日：2009-05-21

申请号：US11943553

申请日：2007-11-20

Applicant: Jayavel Shanmugasundaram ,  Nitin Gupta ,  George Levchenko ,  Fan Yang ,  Chaydar Botev

Inventor： Jayavel Shanmugasundaram ,  Nitin Gupta ,  George Levchenko ,  Fan Yang ,  Chaydar Botev

IPC: G06F17/30 ,  G06F3/048

CPC classification number: G06F16/288

Abstract: The subject matter disclosed herein relates to a method and/or system for generating schema responsive to user navigation patterns.

Abstract translation: 本文公开的主题涉及用于响应于用户导航模式生成模式的方法和/或系统。

公开(公告)号：US20080170456A1

公开(公告)日：2008-07-17

申请号：US11859881

申请日：2007-09-24

Applicant: Fan Yang ,  Ching-Hsiang Lin ,  Jie Ding

Inventor： Fan Yang ,  Ching-Hsiang Lin ,  Jie Ding

IPC: G11C7/00

CPC classification number: G06F13/1636 ,  Y02D10/14

Abstract: A memory refresh method applicable in a system memory is disclosed. The memory system comprises a plurality of memory ranks. It is to determine whether an access request corresponds to the memory rank, and an idle auto-refresh number of the memory rank is calculated if there is no access request corresponds to the memory rank. The memory rank is switched from an auto-refresh mode to a self-refresh mode when the idle auto-refresh number of the memory rank reaches a predetermined value.

Abstract translation: 公开了一种适用于系统存储器的存储器刷新方法。 存储器系统包括多个存储器等级。 确定访问请求是否对应于存储器等级，并且如果没有访问请求对应于存储器等级，则计算存储器等级的空闲自动刷新次数。 当存储器等级的空闲自动刷新次数达到预定值时，存储器等级从自动刷新模式切换到自刷新模式。

公开(公告)号：US20070004393A1

公开(公告)日：2007-01-04

申请号：US11169382

申请日：2005-06-29

Applicant: Dan Forsberg ,  Fan Yang

Inventor： Dan Forsberg ,  Fan Yang

IPC: H04M3/00

CPC classification number: H04W12/08 ,  H04L63/102 ,  H04W4/50 ,  H04W8/245

Abstract: A system is provided for configuring an application for operation onboard a mobile node that includes a plurality of communication interfaces for accessing a plurality of types of networks. The system includes a network entity that can send a request for an application-specific profile for operating an application onboard the mobile node, the request including information identifying the application. In response, a profile server can create/retrieve an application-specific profile based upon the request. The application-specific profile includes one or more application-specific preferences and/or one or more application-specific settings, where at least one of the application-specific preference(s) and/or setting(s) can be interpreted into one or more policy rules capable of at least partially controlling selection of one or more of the communication interfaces of the mobile node during operation of the application. The application can thereafter be configured at least partially based upon the application-specific profile independent of user input.