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403 条记录 (耗时 0.11 秒)

    Cytokine receptor common gamma chain like
    93.
    发明授权
    Cytokine receptor common gamma chain like 有权
    细胞因子受体常见γ链

    公开(公告)号：US06844170B1

    公开(公告)日：2005-01-18

    申请号：US09263626

    申请日：1999-03-05

    申请人： Paul A. Moore ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Paul A. Moore ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K14/715 ,  C07K1/00 ,  C07H21/04 ,  C12N1/20 ,  C12P21/06

    CPC分类号： C07K14/715

    摘要： The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

    摘要翻译： 本发明涉及称为细胞因子受体通用γ链的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

    Antibodies that bind human prostate specific G-protein receptor HPRAJ70
    94.
    发明授权
    Antibodies that bind human prostate specific G-protein receptor HPRAJ70 失效
    结合人前列腺特异性G蛋白受体HPRAJ70的抗体

    公开(公告)号：US06824993B2

    公开(公告)日：2004-11-30

    申请号：US09968033

    申请日：2001-10-02

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K1618

    CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K2317/622

    摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

    摘要翻译： 本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。 更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。 本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。 还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。 本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

    Interleukin-20
    96.
    发明授权
    Interleukin-20 失效
    白细胞介素20

    公开(公告)号：US06486301B1

    公开(公告)日：2002-11-26

    申请号：US09231788

    申请日：1999-01-15

    申请人： Reinhard Ebner ,  Marianne Murphy ,  Steven M. Ruben ,  Jing-Shan Hu ,  D. Roxanne Duan ,  Kimberly A. Florence ,  Craig A. Rosen

    发明人： Reinhard Ebner ,  Marianne Murphy ,  Steven M. Ruben ,  Jing-Shan Hu ,  D. Roxanne Duan ,  Kimberly A. Florence ,  Craig A. Rosen

    IPC分类号： C07K14475

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/54 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及作为细胞因子多肽家族成员的新型IL-20蛋白。 特别地，提供编码人IL-20蛋白的分离的核酸分子。 还提供了IL-20多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL-20活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Polynucleotides encoding chemokine &agr;-6
    98.
    发明授权
    Polynucleotides encoding chemokine &agr;-6 失效
    编码趋化因子α-6的多核苷酸

    公开(公告)号：US06372456B1

    公开(公告)日：2002-04-16

    申请号：US09177304

    申请日：1998-10-23

    申请人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

    发明人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

    IPC分类号： C12N1519

    CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/522

    摘要： The present invention relates to a novel CK(&agr;-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-6 protein. CK&agr;-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.

    摘要翻译： 本发明涉及一种新的CK（α-6蛋白，其是α趋化因子家族的成员，特别是编码人CKalpha-6蛋白的分离的核酸分子，也提供了CKalpha-6多肽 本发明还涉及用于鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法，还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和 免疫系统相关疾病。

    G-protein parathyroid hormone receptor HLTDG74
    99.
    发明授权
    G-protein parathyroid hormone receptor HLTDG74 失效

    公开(公告)号：US06338951B1

    公开(公告)日：2002-01-15

    申请号：US09236468

    申请日：1999-01-25

    申请人： Daniel Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K1472

    CPC分类号： C07K14/723 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    Human G-protein receptor HPRAJ70
    100.
    发明授权
    Human G-protein receptor HPRAJ70 失效

    公开(公告)号：US5948890A

    公开(公告)日：1999-09-07

    申请号：US53303

    申请日：1998-04-01

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K14/705 ,  C07K16/28

    CPC分类号： C07K16/28 ,  A61K2039/505

    摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.