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    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
    2.
    发明授权
    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors 有权
    使用免疫特异性结合尾静脉受体的抗体治疗癌症的方法

    公开(公告)号：US07361341B2

    公开(公告)日：2008-04-22

    申请号：US11391384

    申请日：2006-03-29

    申请人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    发明人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/04 ,  C12P21/08 ,  C07K16/00 ,  C07H21/04

    CPC分类号： C07K16/2878 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体具有例如用于治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或变体 或相关分子，其免疫特异性结合TRAIL受体TR4。

    Antibodies That Immunospecifically Bind to TRAIL Receptors
    3.
    发明申请
    Antibodies That Immunospecifically Bind to TRAIL Receptors 审中-公开
    免疫特异性结合TRAIL受体的抗体

    公开(公告)号：US20090226429A1

    公开(公告)日：2009-09-10

    申请号：US12016372

    申请日：2008-01-18

    申请人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    发明人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    IPC分类号： A61K39/395 ,  C12N5/06

    CPC分类号： C07K16/2878 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。