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403 条记录 (耗时 0.118 秒)

    Antibodies against protective antigen
    91.
    发明授权
    Antibodies against protective antigen 有权
    针对保护性抗原的抗体

    公开(公告)号：US07601351B1

    公开(公告)日：2009-10-13

    申请号：US10602727

    申请日：2003-06-25

    申请人： Craig A. Rosen ,  Michael W. Laird ,  Reiner L. Gentz

    发明人： Craig A. Rosen ,  Michael W. Laird ,  Reiner L. Gentz

    IPC分类号： A61K39/395 ,  A61K39/40

    CPC分类号： C07K16/00 ,  C07K2317/56

    摘要： The present invention relates to antibodies and related molecules that specifically bind to protective antigen of Bacillus anthracis (PA). Such antibodies have uses, for example, in the prevention and treatment of anthrax and anthrax toxin poisoning. The invention also relates to nucleic acid molecules encoding anti-PA antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

    摘要翻译： 本发明涉及与炭疽芽孢杆菌（PA）的保护性抗原特异性结合的抗体和相关分子。 这样的抗体具有例如用于预防和治疗炭疽和炭疽毒素中毒的用途。 本发明还涉及编码抗PA抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。

    Human Tumor Necrosis Factor Receptor-Like 2
    93.
    发明申请
    Human Tumor Necrosis Factor Receptor-Like 2 有权

    公开(公告)号：US20090092608A1

    公开(公告)日：2009-04-09

    申请号：US12241203

    申请日：2008-09-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： A61K39/395 ,  C12N15/11 ,  C07K14/00 ,  C07K16/18

    CPC分类号： C07K16/2878 ,  C07K2317/73 ,  C07K2319/30

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    Death domain containing receptor 4 antibodies and methods
    98.
    发明授权
    Death domain containing receptor 4 antibodies and methods 有权
    含有受体4抗体的死亡域和方法

    公开(公告)号：US08329179B2

    公开(公告)日：2012-12-11

    申请号：US12010108

    申请日：2008-01-18

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： A61K39/395 ,  A61K31/00 ,  C07K16/30

    CPC分类号： C07K14/70578 ,  A01K2267/035 ,  C07K16/2878 ,  C07K2319/30

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

    Antibodies Against Protective Antigen
    99.
    发明申请
    Antibodies Against Protective Antigen 审中-公开
    抗保护性抗原抗体

    公开(公告)号：US20110189197A1

    公开(公告)日：2011-08-04

    申请号：US13028292

    申请日：2011-02-16

    申请人： Craig A. Rosen ,  Michael W. Laird ,  Reiner L. Gentz

    发明人： Craig A. Rosen ,  Michael W. Laird ,  Reiner L. Gentz

    IPC分类号： A61K39/40 ,  C07K16/12 ,  C07K16/46 ,  C12N1/21 ,  A61P31/04

    CPC分类号： C07K16/00 ,  C07K2317/56

    摘要： The present invention relates to antibodies and related molecules that specifically bind to protective antigen of Bacillus anthracis (PA). Such antibodies have uses, for example, in the prevention and treatment of anthrax and anthrax toxin poisoning. The invention also relates to nucleic acid molecules encoding anti-PA antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

    摘要翻译： 本发明涉及与炭疽芽孢杆菌（PA）的保护性抗原特异性结合的抗体和相关分子。 这样的抗体具有例如用于预防和治疗炭疽和炭疽毒素中毒的用途。 本发明还涉及编码抗PA抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。

    Methods of determining the level of human tumor necrosis factor receptor-like 2
    100.
    发明授权
    Methods of determining the level of human tumor necrosis factor receptor-like 2 失效
    确定人肿瘤坏死因子受体样水平的方法2

    公开(公告)号：US07910321B2

    公开(公告)日：2011-03-22

    申请号：US12235837

    申请日：2008-09-23

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen P. Lyn ,  Mark Hurle

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen P. Lyn ,  Mark Hurle

    IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/563 ,  G01N33/577

    CPC分类号： C07K14/7151

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。