-
公开(公告)号：US20050070793A1
公开(公告)日：2005-03-31
申请号：US10990654
申请日：2004-11-17
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09166 , Y10T29/49826
摘要： An improved intracorporeal device such as a guide wire or other guiding member for use within a patient's body that is at least in part visible under magnetic resonance imaging (MRI) but is not detrimentally affected by the imaging is disclosed. The intracorporeal device has a non-conductive proximal core section, an essentially non-magnetic metallic distal core section that is preferably more flexible than the proximal core section, and that has an MRI visible member or coil in the distal section.
摘要翻译： 公开了一种改进的体内器件，例如在病人体内使用的引导线或其它引导部件，其在磁共振成像（MRI）下至少部分可见，但不受成像的不利影响。 体内装置具有不导电的近端芯部分，基本上非磁性的金属远侧芯部分优选地比近侧芯部更柔性，并且在远侧部分中具有MRI可见部件或线圈。
-
公开(公告)号：US09044385B2
公开(公告)日：2015-06-02
申请号：US11749385
申请日：2007-05-16
CPC分类号： A61K9/0019 , A61K9/127 , A61K9/16 , A61K9/1694 , A61K9/51 , A61K47/6915 , A61K47/6925
摘要： Methods for treating a vascular disease by delivering therapeutic compositions with enhanced endothelium targeting are disclosed.
摘要翻译： 公开了通过递送具有增强的内皮靶向的治疗组合物来治疗血管疾病的方法。
-
公开(公告)号：US08951595B2
公开(公告)日：2015-02-10
申请号：US12636079
申请日：2009-12-11
申请人： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
发明人： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
CPC分类号： A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
摘要翻译： 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，并且可以包括第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。
-
公开(公告)号：US08852264B2
公开(公告)日：2014-10-07
申请号：US13618602
申请日：2012-09-14
申请人： Stephen Pacetti , Pamela A. Kramer
发明人： Stephen Pacetti , Pamela A. Kramer
CPC分类号： A61L31/18 , A61F2/91 , A61F2/92 , A61L31/022
摘要： The present invention includes a radiopaque stent comprising a cylindrical main body. The tubular main body comprises a cobalt chromium alloy that comprises cobalt, chromium and one or more radiopaque materials.
摘要翻译： 本发明包括一种包括圆柱形主体的不透射线支架。 管状主体包括钴铬合金，其包括钴，铬和一种或多种不透射线材料。
-
95.发明授权公开(公告)号：US08647680B2
公开(公告)日：2014-02-11
申请号：US12789002
申请日：2010-05-27
IPC分类号： A61K9/14 , A61K33/00 , A61K31/198 , A61P9/10 , A61M25/00
CPC分类号： A61K33/00 , A61K9/00 , A61K31/198 , A61K38/005 , A61K38/44 , A61L27/38 , A61L29/16 , A61L31/16 , A61L2300/40
摘要： Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.
摘要翻译： 本文公开了在身体血管的损伤部位诱导细胞例如巨噬细胞凋亡的方法和组合物。 一氧化氮可以直接或间接地递送到治疗部位以增加巨噬细胞凋亡。 交付可以包括一氧化氮气体，一氧化氮在水溶液中的位置特异性递送或释放一氧化氮或从内源产生一氧化氮的物质。 可以通过诸如导管组件，支架或其它合适的装置之类的递送系统实现递送。
-
96.发明授权Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers 有权具有两性离子部分和二羟基苯基部分的共聚物以及用共聚物涂覆的医疗装置公开(公告)号：US08399584B2
公开(公告)日：2013-03-19
申请号：US13045450
申请日：2011-03-10
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： C08F130/02
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Copolymers are manufactured to include a zwitterionic monomer (e.g., methacryloyloxyethyl phosphorylcholine monomer), a dihydroxyphenyl derivatized monomer, and optionally one or more additional monomers. The dihydroxyphenyl derivatized monomer gives the copolymers excellent adhesion properties. Optional monomers include a cationic amino monomer, a hydrocarbon monomer, and/or a hydrophilic monomer. The copolymers are biocompatible and can be used with medical devices.
摘要翻译： 制备共聚物以包括两性离子单体（例如，甲基丙烯酰氧基乙基磷酸胆碱单体），二羟基苯基衍生的单体和任选的一种或多种另外的单体。 二羟基苯基衍生的单体使共聚物具有优异的粘合性能。 任选的单体包括阳离子氨基单体，烃单体和/或亲水单体。 共聚物是生物相容的并且可以与医疗装置一起使用。
-
公开(公告)号：US08361538B2
公开(公告)日：2013-01-29
申请号：US12331290
申请日：2008-12-09
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： B05D3/14
CPC分类号： B05D1/04 , A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2420/02 , B05B5/087 , B05B13/0228 , B05B17/06
摘要： Devices and methods for applying a coating to an implantable device are disclosed. A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The ultrasonic material delivery apparatus includes an ultrasonic generator. At least one of the ultrasonic material delivery apparatus and the implantable device has a positive or negative electric charge. An application material is applied to the implantable device using the ultrasonic material delivery apparatus.
摘要翻译： 公开了将涂层施加到可植入装置的装置和方法。 公开了一种将涂层施加到可植入装置的方法。 该方法包括相对于超声波材料输送装置定位可植入装置。 超声波材料输送装置包括超声波发生器。 超声波材料输送装置和可植入装置中的至少一个具有正或负电荷。 使用超声波材料输送装置将施加材料施加到可植入装置。
-
公开(公告)号：US08221821B1
公开(公告)日：2012-07-17
申请号：US11983663
申请日：2007-11-09
申请人： Lisa Weldon , Stephen Pacetti
发明人： Lisa Weldon , Stephen Pacetti
CPC分类号： A61L31/16 , A61F2/86 , A61F2240/00 , A61F2250/0067 , A61L31/10 , A61L2300/00 , A61L2420/08 , B05D3/12
摘要： The present invention provides a method of manufacturing a stent having a coating, comprising providing a tubular stent having a lumenal side and an ablumenal side; applying a coating composition to the stents such that the coating composition contacts the lumenal and ablumenal sides of the stent; and modifying the diameter of the stent from a first diameter to a second diameter during the process of applying the coating composition.
摘要翻译： 本发明提供一种制造具有涂层的支架的方法，包括提供具有腔侧和侧面的管状支架; 将涂层组合物施加到支架，使得涂层组合物接触支架的腔和侧面; 以及在施加所述涂料组合物的过程中将所述支架的直径从第一直径改变为第二直径。
-
99.发明授权公开(公告)号：US08197880B2
公开(公告)日：2012-06-12
申请号：US12575744
申请日：2009-10-08
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： A61L33/00
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： A method of using a biocompatible polymer is used. Biocompatible polymers are manufactured to include an ammo acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.
摘要翻译： 使用使用生物相容性聚合物的方法。 制备生物相容性聚合物以包含氨基酸模拟单体和一种或多种疏水性丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。
-
公开(公告)号：US20110160391A1
公开(公告)日：2011-06-30
申请号：US13045465
申请日：2011-03-10
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： C09D177/00
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.
-
-
-
-
-
-
-
-
-
搜索结果
178 条记录 (耗时 0.053 秒)
