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104 条记录 (耗时 0.051 秒)

    Method for generating hypermutable organisms
    92.
    发明申请
    Method for generating hypermutable organisms 有权
    产生超可变生物体的方法

    公开(公告)号：US20050188428A1

    公开(公告)日：2005-08-25

    申请号：US10873114

    申请日：2004-06-23

    申请人： Nicholas Nicolaides ,  Philip Sass ,  Luigi Grasso ,  Bert Vogelstein ,  Kenneth Kinzler

    发明人： Nicholas Nicolaides ,  Philip Sass ,  Luigi Grasso ,  Bert Vogelstein ,  Kenneth Kinzler

    IPC分类号： C07K14/47 ,  C12N15/01 ,  C12N15/10 ,  A01K67/027 ,  C12N15/85

    CPC分类号： C12N15/1024 ,  C07K14/47 ,  C12N15/01 ,  C12N15/102

    摘要： Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. The enhanced rate of mutation can be further augmented using mutagens. Moreover, the hypermutability of mismatch repair deficient cells can be remedied to stabilize cells or mammals with useful mutations.

    摘要翻译： 人类错配修复基因的主要阴性等位基因可用于产生超可变细胞和生物体。 通过将这些基因引入细胞和转基因动物，可以比通过依赖于突变的自然速率更有效地制备具有新颖和有用性质的新细胞系和动物品种。 使用诱变剂可以进一步增强突变率的增强。 此外，错配修复缺陷细胞的高度易失性可以补救以稳定具有有用突变的细胞或哺乳动物。

    Variant cell surface molecule associated with cancer
    93.
    发明申请
    Variant cell surface molecule associated with cancer 审中-公开
    与癌症相关的变异细胞表面分子

    公开(公告)号：US20050054056A1

    公开(公告)日：2005-03-10

    申请号：US10912922

    申请日：2004-08-05

    申请人： Wolfgang Ebel ,  Luigi Grasso ,  Nicholas Nicolaides ,  Philip Sass

    发明人： Wolfgang Ebel ,  Luigi Grasso ,  Nicholas Nicolaides ,  Philip Sass

    IPC分类号： C07K16/30 ,  G01N33/53 ,  C07H21/04 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K16/30

    摘要： The protein and nucleic acid sequences of mesovt2, specific antibodies thereto, methods for targeting and/or inhibiting the growth of cells bearing mesovt2, and methods of use of mesovt2 for diagnosing malignancy are provided. Methods of use of the mesovt2 antibodies in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the mesovt2 antigen, such as pancreatic adenocarcinoma, lung carcinoma, and ovarian cancer, also are provided. The invention also relates to cells expressing the monoclonal antibodies, derivatives, and fragments.

    摘要翻译： 提供mesovt2的蛋白质和核酸序列，其特异性抗体，靶向和/或抑制携带mesovt2的细胞生长的方法，以及mesovt2用于诊断恶性肿瘤的方法。 还提供了使用mesovt2抗体治疗某些癌症的方法，特别是已经增加mesovt2抗原例如胰腺癌，肺癌和卵巢癌的细胞表面表达的癌症。 本发明还涉及表达单克隆抗体，衍生物和片段的细胞。

    Anti-Mesothelin Antibodies
    96.
    发明申请
    Anti-Mesothelin Antibodies 有权
    抗间皮素抗体

    公开(公告)号：US20090202559A2

    公开(公告)日：2009-08-13

    申请号：US11373546

    申请日：2006-03-09

    申请人： Wolfgang Ebel ,  Luigi Grasso ,  Nicholas Nicolaides ,  Philip Sass ,  Eric Routhier

    发明人： Wolfgang Ebel ,  Luigi Grasso ,  Nicholas Nicolaides ,  Philip Sass ,  Eric Routhier

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/30

    CPC分类号： C07K16/28 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/77

    摘要： This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.

    摘要翻译： 本发明涉及单克隆和多克隆抗体的使用，其特异性结合并被间皮素阳性细胞内化，并且还诱导免疫效应子活性如抗体依赖性细胞毒性。 该抗体可用于特异性递送表达间皮素的药物学药剂，以及引发免疫效应物特异性对肿瘤细胞和前体的活性。 本发明还涉及表达单克隆抗体，多克隆抗体，抗体衍生物如人，人源化和嵌合单克隆抗体的细胞，抗体片段，表达单克隆抗体的哺乳动物细胞，衍生物和片段，以及使用 抗体，衍生物和片段。

    Antibodies And Methods For Generating Genetically Altered Antibodies With High Affinity
    100.
    发明申请
    Antibodies And Methods For Generating Genetically Altered Antibodies With High Affinity 有权
    用于产生具有高亲和力的遗传改变的抗体的抗体和方法

    公开(公告)号：US20070244302A1

    公开(公告)日：2007-10-18

    申请号：US11746868

    申请日：2007-05-10

    申请人： Nicholas Nicolaides ,  Luigi Grasso ,  Philip Sass

    发明人： Nicholas Nicolaides ,  Luigi Grasso ,  Philip Sass

    IPC分类号： C12P21/00 ,  C12P21/08

    CPC分类号： C12N15/01 ,  C07K16/00 ,  C07K16/4291 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/92 ,  C12N15/1024

    摘要： Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the affinity of monoclonal antibodies and monoclonal antibodies with increased affinity.

    摘要翻译： 人类错配修复基因的主要阴性等位基因可用于产生超可变细胞和生物体。 通过将这些基因引入细胞和转基因动物，可以比通过依赖于突变的自然速率更有效地制备具有新颖和有用性质的新细胞系和动物品种。 这些方法可用于在针对感兴趣的抗原的免疫球蛋白基因内产生遗传多样性，以产生具有增强的生化活性的改变的抗体。 此外，这些方法可用于产生具有增加的抗体产生水平的产生抗体的细胞。 本发明还提供了增加亲和力的单克隆抗体和单克隆抗体的亲和力的方法。