公开(公告)号：US08248312B2

公开(公告)日：2012-08-21

申请号：US12551800

申请日：2009-09-01

申请人： Ning Guan ,  Koichi Ito

发明人： Ning Guan ,  Koichi Ito

IPC分类号： H01Q1/24 ,  H01Q1/36

CPC分类号： H01Q1/243 ,  H01Q1/36 ,  H01Q5/371 ,  H01Q9/42

摘要： The present invention provides an antenna that is small in size and has band frequencies corresponding to multibands, and a wireless communication apparatus including the antenna. The antenna according to the present invention has two radiation elements 12a and 12b connected to a ground plate 11 via a shorting pin. The two radiation elements 12a and 12b each have a lower arm and an upper arm that are formed through bending. The lower arm is connected to the shorting pin and is located closer to the ground plate 11 than the upper arm is. At least one of the lower arm and the upper arm has a meandered structure.

摘要翻译： 本发明提供一种尺寸小且具有对应于多个频带的频带频率的天线，以及包括该天线的无线通信装置。 根据本发明的天线具有通过短路引脚连接到接地板11的两个辐射元件12a和12b。 两个辐射元件12a和12b各自具有通过弯曲形成的下臂和上臂。 下臂连接到短路销，并且比上臂更靠近接地板11。 下臂和上臂中的至少一个具有蜿蜒的结构。

公开(公告)号：US08048878B2

公开(公告)日：2011-11-01

申请号：US12403565

申请日：2009-03-13

申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

IPC分类号： C07D491/02 ,  C07D265/36 ,  C07D498/02 ,  C07D295/00 ,  A61K31/535 ,  A61K31/50 ,  A61K31/44 ,  A01N43/60

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.

摘要翻译： 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式（I）表示的两个环状肉桂酰胺化合物：其中表示单键或双键; Ar 1表示可被1〜3个取代基取代的苯基或吡啶基; R1和R2各自表示C1-6烷基，羟基等; Z1表示亚甲基或亚乙烯基，其可以被1或2个选自取代基组A1，氧原子或可被选自取代基组A1的取代基取代的亚氨基取代基取代; p，q和r各自表示0〜2的整数，其具有降低A＆bgr 40和A＆bgr 42生成的效果，因此特别可用作由A＆bgr引起的神经变性疾病的预防或治疗剂。 如阿尔茨海默病或唐氏综合症。

公开(公告)号：US08008293B2

公开(公告)日：2011-08-30

申请号：US12522281

申请日：2008-02-27

申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Nobuaki Sato ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Nobuaki Sato ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

IPC分类号： C07D498/04 ,  A61K31/5375

CPC分类号： C07D498/04

摘要： The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.

摘要翻译： 本发明涉及由式（I）表示的化合物：其中R1表示C1-3烷基，R2表示氢原子或C1-3烷基，Ar表示可被基团取代的苯基等 1〜3个取代基，X表示氧原子等，n和m相同或不同，为0〜2的整数，或药理学上可接受的盐及其作为药物的用途。

公开(公告)号：US07973033B2

公开(公告)日：2011-07-05

申请号：US13005064

申请日：2011-01-12

申请人： Teiji Kimura ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Eriko Doi ,  Mamoru Takaishi ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Takashi Doko

发明人： Teiji Kimura ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Eriko Doi ,  Mamoru Takaishi ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Takashi Doko

IPC分类号： C07D471/04 ,  C07D498/04 ,  A61K31/5383 ,  A61K31/5025

CPC分类号： C07D403/10 ,  C07D471/04 ,  C07D498/04

摘要： The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, Ar2 represents a phenyl group that may be substituted with a C1-6 alkoxy group, or the like, X1 represents a double bond or the like, and Het represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, which is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

公开(公告)号：US07939549B2

公开(公告)日：2011-05-10

申请号：US12395378

申请日：2009-02-27

申请人： Satoshi Nagato ,  Kohshi Ueno ,  Koki Kawano ,  Yoshihiko Norimine ,  Koichi Ito

发明人： Satoshi Nagato ,  Kohshi Ueno ,  Koki Kawano ,  Yoshihiko Norimine ,  Koichi Ito

IPC分类号： C07D401/04 ,  A61K31/44

CPC分类号： C07D213/70 ,  C07D213/64 ,  C07D213/65 ,  C07D213/69 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D213/76 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/06 ,  C07F7/1804

摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

摘要翻译： 本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。 由下式表示的化合物，其盐或其水合物。 在该式中，Q表示NH，O或S; 并且R 1，R 2，R 3，R 4和R 5彼此相同或不同，各自表示氢原子，卤素原子，C 1-6烷基或由式-XA表示的基团（其中X表示单 键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等）。

公开(公告)号：US07923563B2

公开(公告)日：2011-04-12

申请号：US11663550

申请日：2005-10-25

申请人： Ikuo Kushida ,  Eriko Doi ,  Koichi Ito

发明人： Ikuo Kushida ,  Eriko Doi ,  Koichi Ito

IPC分类号： C07D401/06

CPC分类号： C07D401/10

摘要： An amorphous object of (3E)-1-[l(s)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4methyl-1H-imidazol-1-yl)benzylidene]piperidine-2-one, which is represented by the formula (1) and has Aβ-production inhibitory activity. The amorphous object has such satisfactory properties that it has excellent solubility, is stable, does not readily become a crystalline form, and has low hygroscopicity. It is hence suitable for use in pharmaceutical preparations.

摘要翻译： （3E）-1- [1（S）-1-（4-氟苯基）乙基] -3- [3-甲氧基-4-（4-甲基-1H-咪唑-1-基）亚苄基] （1）表示并具有生产抑制活性。 无定形物具有这样令人满意的性质，其具有优异的溶解性，稳定性，不容易变成结晶形式，并且具有低吸湿性。 因此适用于药物制剂。

公开(公告)号：US20100105904A1

公开(公告)日：2010-04-29

申请号：US12301428

申请日：2007-05-18

申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Takehiko Miyagawa ,  Nobuaki Sato ,  Toshihiko Kaneko ,  Kogyoku Shin ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Takehiko Miyagawa ,  Nobuaki Sato ,  Toshihiko Kaneko ,  Kogyoku Shin ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

IPC分类号： C07D233/64 ,  C07D405/12 ,  C07D403/10

CPC分类号： C07D233/64 ,  C07D249/06 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12 ,  C07D403/10 ,  C07D405/12

摘要： Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group; X1 represents a single bond; R1 and R2 respectively represent a C1-6 alkyl group or the like which may be substituted with a substituent such as a 5- to 14-membered aromatic heterocyclic group; and R3 represents a hydrogen atom or the like.)

摘要翻译： 公开了由下式（I）表示的化合物或其药理学上可接受的盐。 还公开了化合物或盐作为药物产品的用途。 （式中，Ar 1表示可被C 1-6烷基取代的咪唑基，Ar 2表示可被C 1-6烷氧基取代的苯基，X 1表示单键; R 1，R 2分别表示 可以被诸如5至14元芳族杂环基团的取代基取代的C 1-6烷基等; R 3表示氢原子等。

公开(公告)号：US20090274997A1

公开(公告)日：2009-11-05

申请号：US12165961

申请日：2008-07-01

申请人： Eiko Kosuge ,  Koichi Ito ,  Takafumi Aoki

发明人： Eiko Kosuge ,  Koichi Ito ,  Takafumi Aoki

IPC分类号： A61C19/00

CPC分类号： G06K9/522 ,  A61B6/14 ,  G06K9/6206 ,  G06T7/33 ,  G06T2207/10116 ,  G06T2207/30036

摘要： A system for comparing dental X-ray images includes a positional displacement calculator calculating a positional displacement between dental X-ray test and reference images by using phase-only correlation, a positional displacement corrector correcting the positional displacement, a base point extractor defining, as a base image, any one of the dental X-ray test and reference images, and defining, as a corresponding image, the other one of the two dental images, and extracting base points from the base image, a corresponding point extractor extracting corresponding points, which correspond to the base points, from the corresponding image, a correspondence calculator calculating correspondence between the base points and the corresponding points, a nonlinear distortion corrector correcting a nonlinear distortion between the base image and the corresponding image, based on the correspondence, and a similarity calculator finding, by using phase-only correlation, a similarity between the base image and the corresponding image.

摘要翻译： 用于比较牙齿X射线图像的系统包括位置偏移计算器，其通过使用相位相关来计算牙科X射线测试和参考图像之间的位置偏移，校正位置偏移的位置偏移校正器，将基点提取器定义为 基础图像，牙科X射线测试和参考图像中的任一个，并且将两个牙齿图像中的另一个定义为相应的图像，并且从基本图像提取基点，相应的点提取器提取相应的点 对应于基点的对应计算器，计算基点与对应点之间的对应关系，基于对应关系校正基图像与对应图像之间的非线性失真的非线性失真校正器，以及 相似度计算器通过使用相位相关来找出相似度 基本图像和相应的图像。

公开(公告)号：US20090048448A1

公开(公告)日：2009-02-19

申请号：US12093929

申请日：2006-11-17

申请人： Ikuo Kushida ,  Eriko Doi ,  Koichi Ito ,  Taiju Nakamura

发明人： Ikuo Kushida ,  Eriko Doi ,  Koichi Ito ,  Taiju Nakamura

IPC分类号： C07D401/10

CPC分类号： C07D401/10

摘要： The invention provides crystals of dihydrochloride monohydrate of the compound of the following formula having an Aβ production inhibiting effect which crystals are characterized by exhibiting a diffraction peak at an angle of diffraction (2θ±0.2°) of 10.9° in powder X-ray diffractometry. Further, the invention also provides the compound in the form of various salts, crystal forms and amorphous forms which are suitable for the development of drugs.

摘要翻译： 本发明提供下式化合物的二盐酸盐一水合物晶体，其具有抑制Aβ生成的作用，其结晶的特征在​​于在粉末X射线衍射中以衍射角（2θ±0.2°）为10.9°的衍射峰。 此外，本发明还提供了适合于开发药物的各种盐，晶型和无定形形式的化合物。

公开(公告)号：US20080243108A1

公开(公告)日：2008-10-02

申请号：US12076496

申请日：2008-03-19

申请人： Naho Murakami ,  Koichi Ito

发明人： Naho Murakami ,  Koichi Ito

IPC分类号： A61F9/008 ,  A61B18/20

CPC分类号： A61F9/008 ,  A61B2018/2035 ,  A61F9/00821 ,  A61F2009/00863

摘要： An ophthalmic laser treatment apparatus comprises: a laser source that emits a laser beam for treatment of an affected part of a patient's eye; an optical fiber that transmits the laser beam emitted from the laser source; and a delivery optical system that irradiates the laser beam emitted from the optical fiber to the affected part of the patient's eye, the delivery optical system including: a plurality of diffraction optical elements each being configured to shape a beam profile of the laser beam at an emission end face of the optical fiber into a beam profile having one of a uniform intensity and a lower intensity in the center than on the periphery on the affected part and also to shape the laser beam to have a different spot size on the affected part of the patient's eye; and a changing unit which selectively disposing one of the diffraction optical elements on an optical path.

摘要翻译： 一种眼科激光治疗装置，包括：激光源，其发射用于治疗患者眼睛的患部的激光束; 透射从激光源发射的激光束的光纤; 以及输送光学系统，其将从所述光纤发射的激光束照射到所述患者眼睛的受影响部分，所述输送光学系统包括：多个衍射光学元件，每个衍射光学元件被配置为在所述激光束的一个 光纤的发射端面变成具有在中心上的均匀强度和较低强度之一的光束轮廓，而不是在受影响的部分上的周边上，并且还使激光束的形状在受影响的部分具有不同的光斑尺寸 病人的眼睛; 以及在光路上选择性地配置衍射光学元件中的一个的改变单元。