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公开(公告)号：US08802089B2
公开(公告)日：2014-08-12
申请号：US12811637
申请日：2008-12-19
Applicant: Edward Norbert Van Den Brink , Paul Parren , Jan Van De Winkel , Aran Frank Labrijn , Frank Everhardus Martinus Rebers , Esther Cornelia Wilhelmina Breij
Inventor： Edward Norbert Van Den Brink , Paul Parren , Jan Van De Winkel , Aran Frank Labrijn , Frank Everhardus Martinus Rebers , Esther Cornelia Wilhelmina Breij
IPC: A61K39/395
CPC classification number: C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human CD32b and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
Abstract translation: 公开了与人CD32b和相关的基于抗体的组合物和分子结合的分离的单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US20140170156A1
公开(公告)日：2014-06-19
申请号：US14074226
申请日：2013-11-07
Applicant: GENMAB A/S
Inventor： Jessica TEELING , Paul PARREN , Ole BAADSGAARD , Debra HUDSON , Jørgen PETERSEN
IPC: C07K16/24 , G01N33/68 , C07K16/42 , A61K39/395 , A61K45/06
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
Abstract: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20140170149A1
公开(公告)日：2014-06-19
申请号：US14112859
申请日：2012-04-20
Applicant: Joost J. Neijssen , Joyce I. Meesters , Bart De Goeij , Aran Frank Labrijn , Paul Parren , Janine Schuurman
Inventor： Joost J. Neijssen , Joyce I. Meesters , Bart De Goeij , Aran Frank Labrijn , Paul Parren , Janine Schuurman
Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
Abstract translation: 公开了包含与人表皮生长因子受体2（HER2）的表位结合的一个抗原结合区和与人CD3结合的一个抗原结合区以及相关的基于抗体的组合物和分子的双特异性抗体。 还公开了包含抗体的药物组合物和用于制备和使用抗体的方法。
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公开(公告)号：US20130345406A1
公开(公告)日：2013-12-26
申请号：US13912581
申请日：2013-06-07
Applicant: Genmab A/S
Inventor： Jan Van De Winkel , Tom Vink , Janine Schuurman , Paul Parren , Rob Aalberse , Marijn Van Der Neut Kolfschoten
CPC classification number: C07K16/2887 , A61K47/6803 , A61K47/6813 , A61K47/6835 , A61K47/6839 , A61K47/6845 , A61K47/6849 , A61K51/10 , A61K51/1006 , A61K51/1021 , A61K51/1027 , A61K51/103 , A61K51/1039 , A61K2039/505 , C07K16/00 , C07K16/16 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/94
Abstract: The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).
Abstract translation: 本发明涉及稳定的IgG4抗体，涉及产生此类抗体的方法以及此类抗体作为药物的用途。 在一个主要方面，本发明涉及一种稳定的IgG4抗体，其包含重链和轻链，其中所述重链包含具有在位置（409）处的Arg残基取代的人IgG4恒定区， 位置（405）或位置（370）处的Lys残基。
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95.发明授权Methods of treating cancer with human monoclonal antibodies against interleukin 8 有权用针对白介素8的人单克隆抗体治疗癌症的方法公开(公告)号：US08603469B2
公开(公告)日：2013-12-10
申请号：US13337798
申请日：2011-12-27
Applicant: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
Inventor： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
IPC: A61K39/395
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
Abstract: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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Patent Agency Ranking
公开(公告)号：US08586041B2
公开(公告)日：2013-11-19
申请号：US12464057
申请日：2009-05-11
Applicant: Jan G. J. van de Winkel , Marcus Antonius van Dijk , Edward Halk , Arnout F. Gerritsen , Jorgen Petersen , Ole Baadsgaard
Inventor： Jan G. J. van de Winkel , Marcus Antonius van Dijk , Edward Halk , Arnout F. Gerritsen , Jorgen Petersen , Ole Baadsgaard
IPC: A61K39/395 , C12P21/08 , C07K16/28
CPC classification number: C07K16/2863 , A01K2217/05 , A01K2217/075 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56966
Abstract: Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US08529902B2
公开(公告)日：2013-09-10
申请号：US10687799
申请日：2003-10-17
Applicant: Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
Inventor： Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
IPC: C07K16/18 , C07K16/28 , C07K16/30 , A61K39/395 , C12N5/12
CPC classification number: C07K16/2887 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4258 , C07K2317/21 , C07K2317/54 , C07K2317/56 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , G01N33/686
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了结合并抑制人CD20的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US08105588B2
公开(公告)日：2012-01-31
申请号：US12616615
申请日：2009-11-11
Applicant: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
Inventor： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
IPC: A61K39/395
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
Abstract: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20120020952A1
公开(公告)日：2012-01-26
申请号：US13146297
申请日：2010-01-26
Applicant: Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
Inventor： Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
IPC: A61K31/7088 , C07K16/00 , C12N5/10 , C12P21/00 , C12P21/02
CPC classification number: C07K16/00 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/626
Abstract: The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bivalent antibodies is produced. The invention also relates to mixtures of antibodies obtainable by the method of the invention and to light chain sequences that are particularly useful in the method of the invention.
Abstract translation: 本发明涉及在单个重组宿主细胞中产生包含两种或多种不同抗体的混合物的方法。 在一个实施方案中，产生不同单价抗体的混合物。 在另一个实施方案中，产生一价和二价抗体的混合物。 本发明还涉及可通过本发明的方法获得的抗体混合物和特别可用于本发明方法的轻链序列。
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公开(公告)号：US20110045007A1
公开(公告)日：2011-02-24
申请号：US12602416
申请日：2008-05-30
Applicant: Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrljn , Paul Parren , Willem Karel Bleeker , FRank Beurskens , Patrick Van Berkel
Inventor： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrljn , Paul Parren , Willem Karel Bleeker , FRank Beurskens , Patrick Van Berkel
IPC: A61K39/395 , C12P21/02 , C12N9/96 , C12N5/071 , C12N5/10 , C12N1/21 , C12N1/15 , C12N15/63 , C07K16/00 , C07K19/00 , C07K16/46 , A61P29/00 , A61P35/00 , A61P3/10 , A61P25/16 , A61P25/08 , A61P25/18 , A61P25/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P7/00 , A61P11/06 , A61P25/24 , A61P7/02 , A61P33/00
CPC classification number: C07K16/28 , A61K47/6813 , A61K47/6849 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K2317/53 , C07K2317/732 , C07K2317/77 , C07K2319/33
Abstract: The present invention provides fusion proteins comprising a first molecule, and a second molecule which is a monovalent immunoglobulin or a fragment of a monovalent immunoglobulin with a long half-life when administered in vivo, methods of making such fusion proteins, pharmaceutical compositions comprising such fusion proteins, and uses thereof.
Abstract translation: 本发明提供包含第一分子和第二分子的融合蛋白，其是当体内施用时具有长半衰期的单价免疫球蛋白或单价免疫球蛋白的片段的第二分子，制备此类融合蛋白的方法，包含这种融合的药物组合物 蛋白质及其用途。
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