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169 条记录 (耗时 0.024 秒)

    Organic compound and method for producing radioactive halogen-labeled organic compound using the same
    93.
    发明授权
    Organic compound and method for producing radioactive halogen-labeled organic compound using the same 失效
    有机化合物及使用其的放射性卤素标记有机化合物的制造方法

    公开(公告)号：US07910745B2

    公开(公告)日：2011-03-22

    申请号：US11915267

    申请日：2006-05-15

    申请人： Masahito Toyama ,  Fumie Kurosaki ,  Akio Hayashi ,  Osamu Ito

    发明人： Masahito Toyama ,  Fumie Kurosaki ,  Akio Hayashi ,  Osamu Ito

    IPC分类号： C07D285/01 ,  C07D207/404 ,  C07D209/48 ,  C07C61/04

    CPC分类号： C07D209/48 ,  A61K51/0406 ,  Y02P20/55

    摘要： It is intended to provide a labeling precursor compound used for selectively producing radioactive halogen-substituted syn-1-amino-3-cyclobutane-carboxylic acids, and to provide a process for producing a radioactive halogen-substituted syn-1-amino-3-cyclobutane-carboxylic acid using the labeling precursor compound. A labeling precursor is used in which a phthalimide group is used as a protective group for protecting the amino group. The syn-form of the radioactive halogen-substituted 1-amino-3-cyclobutane-carboxylic acid can be selectively produced by labeling the labeling precursor with a radioactive halogen followed by deprotecting.

    摘要翻译： 旨在提供用于选择性地制备放射性卤素取代的顺式-1-氨基-3-环丁烷羧酸的标记前体化合物，并提供一种制备放射性卤素取代的顺式-1-氨基-3- 使用标记前体化合物的环丁烷羧酸。 使用标记前体，其中使用邻苯二甲酰亚胺基作为保护氨基的保护基。 放射性卤素取代的1-氨基-3-环丁烷羧酸的合成形式可以通过用放射性卤素标记前述标记前体，然后脱保护来选择性地制备。

    POLYAMIC ACID AND POLYIMIDE
    94.
    发明申请
    POLYAMIC ACID AND POLYIMIDE 有权
    聚氨酯和聚酰亚胺

    公开(公告)号：US20090292103A1

    公开(公告)日：2009-11-26

    申请号：US12373230

    申请日：2007-07-09

    申请人： Hideo Suzuki ,  Takayuki Tamura ,  Yoshikazu Ootsuka

    发明人： Hideo Suzuki ,  Takayuki Tamura ,  Yoshikazu Ootsuka

    IPC分类号： C08G73/10 ,  C07C61/04 ,  C07D307/77

    CPC分类号： C08G73/1078 ,  C07D487/04 ,  C07D493/04 ,  C08G73/1046 ,  C08G73/105 ,  C08G73/1075 ,  C08L79/08

    摘要： A polyamic acid comprising at least 10 mol % repeating units represented by the formula [1] or [2]; and a polyimide represented by the formula [3] or [4] which is obtained from the polyamic acid. A polyimide film having high heat resistance and satisfactory in light-transmitting properties and tensile strength is obtained from the polyamic acid. (In the formulae, R1 and R2 each independently represents hydrogen or C1-10 alkyl; R3 and R4 each independently represents hydrogen, halogeno, C1-10alkyl, or phenyl or the R3 and R4 on adjoining carbon atoms are bonded to each other to form C3-8 cycloalkyl or phenyl; R5 represents a divalent organic group; and n is an integer of 2 or larger.)

    摘要翻译： 包含由式[1]或[2]表示的至少10摩尔％重复单元的聚酰胺酸; 和由聚酰胺酸得到的由式[3]或[4]表示的聚酰亚胺。 从聚酰胺酸得到耐热性高，透光性和拉伸强度良好的聚酰亚胺膜。 （式中，R 1和R 2各自独立地表示氢或C 1-10烷基; R 3和R 4各自独立地表示氢，卤素，C 1-10烷基或苯基，或者相邻碳原子上的R 3和R 4彼此键合形成 C3-8环烷基或苯基; R5表示二价有机基团; n为2以上的整数。）

    Process for Production of Radioactive Fluorine-Labeled Organic Compound
    95.
    发明申请
    Process for Production of Radioactive Fluorine-Labeled Organic Compound 有权
    放射性氟标记有机化合物生产工艺

    公开(公告)号：US20090198085A1

    公开(公告)日：2009-08-06

    申请号：US12227240

    申请日：2007-05-07

    申请人： Akio Hayashi ,  Fumie Kurosaki ,  Masahito Toyama ,  Toshiyuki Shinmura ,  Emi Kaneko

    发明人： Akio Hayashi ,  Fumie Kurosaki ,  Masahito Toyama ,  Toshiyuki Shinmura ,  Emi Kaneko

    IPC分类号： C07C61/04

    CPC分类号： C07C227/18 ,  C07B59/001 ,  C07B2200/05 ,  C07C227/20 ,  C07C2601/04 ,  Y02P20/55 ,  C07C229/48

    摘要： A process is provided for producing [18F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for producing a radioactive fluorine-labeled organic compound, including a deesterification step of retaining, in a reverse-phase column, a compound represented by Formula (1): wherein R1 is a linear or branched C1-C10-alkyl chain or an aromatic substituent, and R2 is a protecting group; charging the column with an alkaline solution to deesterify the compound, and subsequently discharging the alkaline solution from the column to obtain a compound represented by Formula (2): wherein X is sodium or potassium; and a deprotection step of deprotecting the amino-protecting group of the compound obtained in the deesterification step to obtain a compound represented by Formula (3):

    摘要翻译： 提供了用于生产[18F] FACBC的方法，其可以降低杂质的产生量。 公开了一种放射性氟标记的有机化合物的制备方法，包括在反相柱中保留由式（1）表示的化合物的脱酯化步骤：其中R 1是直链或支链的C 1 -C 10 - 烷基链 或芳香族取代基，R2为保护基; 用碱性溶液装入柱子以使化合物脱酯化，然后从柱中排出碱性溶液，得到由式（2）表示的化合物：其中X是钠或钾; 和脱甲基化工序中得到的化合物的氨基保护基脱保护，得到式（3）表示的化合物：

    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND
    96.
    发明申请
    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND 失效
    用于生产不对称四面体碳纳米管的化合物的方法

    公开(公告)号：US20090054648A1

    公开(公告)日：2009-02-26

    申请号：US11914952

    申请日：2006-05-19

    申请人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    发明人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    IPC分类号： C07F5/00 ,  C07C61/04 ,  C07D209/54 ,  C07D401/02

    CPC分类号： C07C255/31 ,  C07B53/00 ,  C07C271/22 ,  C07D209/54 ,  C07D401/04

    摘要： The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.The invention provides a method for producing a compound represented by formula (2): (wherein n is an integer of 2 to 5; R1 represents a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group), which includes treating a compound represented by formula (1): (wherein n, R1, and R2 are the same as defined above; and R3 represents a hydrogen atom, a (substituted) alkyl group, or a (substituted) aralkyl group) under a hydrogen gas atmosphere in the presence of a metallic catalyst.

    摘要翻译： 本发明提供一种生产螺环氨基吡咯烷酮衍生物的工业方法，其是用于生产喹诺酮抗菌剂的中间体。 本发明提供一种制备由式（2）表示的化合物的方法：（其中n为2至5的整数; R 1表示（取代的）烷基或（取代的）芳基; R 2表示（取代的） 烷氧基羰基，（取代的）芳烷氧基羰基，（取代的）脂族酰基或（取代的）芳族酰基），其包括处理由式（1）表示的化合物：其中n，R1和R2是 在氢气气氛下，在金属催化剂的存在下，R 3表示氢原子，（取代的）烷基或（取代的）芳烷基）。

    Carboxylic acid compound having cyclopropane ring
    97.
    发明授权
    Carboxylic acid compound having cyclopropane ring 有权
    具有环丙烷环的羧酸化合物

    公开(公告)号：US07468389B2

    公开(公告)日：2008-12-23

    申请号：US10450816

    申请日：2001-12-18

    申请人： Tomoyuki Nishizaki ,  Akito Tanaka

    发明人： Tomoyuki Nishizaki ,  Akito Tanaka

    IPC分类号： A61K31/215 ,  C07C61/00 ,  C07C61/04

    CPC分类号： C07C61/04 ,  C07C53/134 ,  C07C57/26 ,  C07C61/12 ,  C07C61/28 ,  C07C61/35

    摘要： A carboxylic acid compound having cyclopropane ring(s) of the formula (I): wherein R is alkyl or alkenyl optionally having one or more 1,2-cyclopropylene in a carbon chain and/or optionally having cyclopropyl at the end of a chain,X is a single bond or alkylene, wherein the total number of carbon less the number of cyclopropane ring is 10-25, and a pharmaceutically acceptable salt thereof are provided. The compound (I) shows an LTP-like potentiation of synaptic transmission, allows slow metabolism in the living body, show a stable LTP-like potentiation of synaptic transmission, and is useful as an agent for LTP-like potentiation of synaptic transmission, a cognition-enhancing drug or an agent for the prophylaxis and treatment of dementia, a learning and memory disorder and a neurotransmitter release disorder.

    摘要翻译： 具有式（I）的环丙烷环的羧酸化合物：其中R是在碳链中任选具有一个或多个1,2-亚丙基的烷基或链烯基和/或在链末端任选具有环丙基的羧酸化合物， X是单键或亚烷基，其中提供环丙烷环数少于10-25的碳总数及其药学上可接受的盐。 化合物（I）显示突触传递的LTP样增强，允许活体中的代谢缓慢，表现出稳定的LTP样增强突触传递，并且可用作LTP样增强突触传递的药剂，a 认知增强药物或预防和治疗痴呆，学习和记忆障碍和神经递质释放障碍的药剂。

    Optically active bisoxazoline compounds, process for production of the same and use thereof
    98.
    发明授权
    Optically active bisoxazoline compounds, process for production of the same and use thereof 失效
    光学活性双恶唑啉化合物，其制备方法及其用途

    公开(公告)号：US07288674B2

    公开(公告)日：2007-10-30

    申请号：US10544494

    申请日：2004-02-04

    申请人： Makoto Itagaki ,  Katsuhisa Masumoto

    发明人： Makoto Itagaki ,  Katsuhisa Masumoto

    IPC分类号： C07C61/04 ,  C07D263/10

    CPC分类号： C07D263/12 ,  C07B2200/07 ,  C07C67/347 ,  C07C215/28 ,  C07C233/18 ,  C07C2601/02 ,  C07C69/747

    摘要： Optically active bisoxazoline compounds represented by the general formula (1), a process for producing the compounds, and a process for producing cyclopropanecarboxylic esters by using the same: wherein R1 and R2 are the same and each represents C1-6 alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted phenyl or R1 and R2 are bonded each other together with the carbon atom of oxazoline ring to which they are bonded to form a ring; R3 is substituted or unsubstituted naphthyl; R4 and R5 are the same and each represent hydrogen or C1-6 alkyl, or R4 and R5 are bonded each other together with the carbon atom to which they are bonded to form a cycloalkyl ring having 3 to 6 carbon atoms; and * represents an asymmetric center.

    摘要翻译： 由通式（1）表示的光学活性的双恶唑啉化合物，该化合物的制备方法以及使用该化合物制备环丙烷羧酸酯的方法：其中R 1和R 2， SUP>相同，各自表示C 1-6烷基，取代或未取代的芳烷基或取代或未取代的苯基或R 1和R 2 O 2 >与它们所键合的恶唑啉环的碳原子一起形成环; R 3是取代或未取代的萘基; R 4和R 5是相同的，并且各自表示氢或C 1-6烷基，或R 4， R 5和它们所连接的碳原子一起形成具有3〜6个碳原子的环烷基环; *表示非对称中心。

    Process for production of 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivatives
    99.
    发明授权
    Process for production of 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivatives 失效
    3,3-二甲基-2-甲酰基环丙烷羧酸衍生物的制备方法

    公开(公告)号：US07262320B2

    公开(公告)日：2007-08-28

    申请号：US10501094

    申请日：2002-12-26

    申请人： Kouji Yoshikawa

    发明人： Kouji Yoshikawa

    IPC分类号： C07C69/74 ,  C07C61/04

    CPC分类号： C07C51/373 ,  C07C67/333 ,  C07C2601/02 ,  C07C62/16 ,  C07C69/757

    摘要： A process for the production of a 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivative of formula (2): wherein R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl, which process comprises reacting a 3,3-dimethyl-2-(2-methyl-1-propenyl)cyclopropanecarboxylic acid compound of formula (1): wherein R is as defined above, with a periodic acid compound in the presence of a ruthenium compound.

    摘要翻译： 制备式（2）的3,3-二甲基-2-甲酰基环丙烷羧酸衍生物的方法：其中R是氢，取代或未取代的烷基，取代或未取代的芳基或取代或未取代的芳烷基，该方法包括使 在钌化合物的存在下，式（1）的3,3-二甲基-2-（2-甲基-1-丙烯基）环丙烷羧酸化合物：其中R如上定义，与高碘酸化合物反应。