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    Process for the preparation of a 2-pyrrolidone
    91.
    发明授权
    Process for the preparation of a 2-pyrrolidone 失效
    制备2-吡咯烷酮的方法

    公开(公告)号：US4325872A

    公开(公告)日：1982-04-20

    申请号：US218465

    申请日：1980-12-22

    Applicant: Peter J. N. Meyer ,  Johannes G. M. Nieuwkamp

    Inventor： Peter J. N. Meyer ,  Johannes G. M. Nieuwkamp

    IPC: C07D207/263 ,  B01J23/00 ,  C07B61/00 ,  C07D201/08 ,  C07D207/267

    CPC classification number: C07D201/08 ,  Y02P20/584

    Abstract: An improved method for hydrogenating succinonitrile, optionally carrying substituents, to form 2-pyrrolidones, in the liquid phase in the presence of ammonia, using a fixed-bed catalyst wherein the catalyst may be regenerated by successively passing liquid ammonia at 75.degree.-130.degree. C., then hydrogen at 130.degree.-350.degree. C., and then liquid ammonia again at 75.degree.-130.degree. C. over the catalyst.

    Abstract translation: 使用固定床催化剂，在氨水存在下，在液相中氢化丁腈橡胶（任选携带取代基）形成2-吡咯烷酮的改进方法，其中催化剂可以通过在75°-130℃依次通过液氨而再生 然后在130-350℃下加入氢气，然后在75°-130℃再次加入氨水，过催化剂。

    Process for antibiotic FR 1923 and related compounds
    92.
    发明授权
    Process for antibiotic FR 1923 and related compounds 失效
    抗生素FR1923及相关化合物的制备方法

    公开(公告)号：US4158004A

    公开(公告)日：1979-06-12

    申请号：US739161

    申请日：1976-11-05

    Applicant: Gary A. Koppel ,  Robin D. G. Cooper

    Inventor： Gary A. Koppel ,  Robin D. G. Cooper

    IPC: C07D205/08 ,  C07D205/085 ,  C07D205/095 ,  C07D277/06 ,  C07D498/04 ,  C07D513/04 ,  C07D201/08

    CPC classification number: C07D513/04 ,  C07D205/085 ,  C07D205/095 ,  C07D277/06 ,  Y02P20/55

    Abstract: Process for 1-[.alpha.-(carboxy)-4-hydroxy or protected-hydroxybenzyl]-3-acylamidoazetidin-2-one esters, useful intermediates for preparing antibiotic FR 1923, comprising the ring opening of a 2-acyl-3,3-dialkyl-7-oxo-.alpha.-[4-(protected-hydroxyphenyl]-4-thia-2,6-diazabicyclo[3.2.0]heptane-6-acetic acid, ester sulfoxide with a sulfonic acid and heat to provide a 3-acylamido-4-(2-oxaalkylthio)azetidin-2-one ester which on treatment with sulfuryl chloride affords a reaction product mixture that is then reduced with an organo tin hydride, e.g., tri(n-butyl)tin hydride, to the product. N-Deacylation of the 3-acylamido group followed by acylation with the 3-acyl portion of FR 1923, deblocking of the amino-protecting group and deesterification affords FR 1923.

    Abstract translation: 1- [α-（羧基）-4-羟基或被保护的羟基苄基] -3-酰基氨基吖丁啶-2-酮酯的方法，用于制备抗生素FR1923的有用中间体，包括2-酰基-3,3 - 二烷基-7-氧代-α-[4-（保护的 - 羟基苯基）-4-硫杂-2,6-二氮杂双环[3.2.0]庚烷-6-乙酸，与磺酸并加热的酯亚砜， 3-酰基酰胺基-4-（2-氧杂烷硫基）氮杂环丁-2-酮，其用硫酰氯处理得到反应产物混合物，然后用有机锡氢化物如三（正丁基）氢化锡还原至 产物，3-酰基酰氨基的N-去酰化，随后用FR 1923的3-酰基部分酰化，氨基保护基团的解封端和脱酯化，得到FR 1923。

    Preparation of 2-pyrrolidone
    93.
    发明授权
    Preparation of 2-pyrrolidone 失效
    2-吡咯烷酮的制备

    公开(公告)号：US3884936A

    公开(公告)日：1975-05-20

    申请号：US35327773

    申请日：1973-04-23

    Applicant: SUN RESEARCH DEVELOPMENT

    Inventor： HOLLSTEIN ELMER J

    IPC: C07D201/08 ,  C07D27/08

    CPC classification number: C07D201/08

    Abstract: A process for preparing 2-pyrrolidone which comprises reacting maleic acid or maleic anhydride with hydrogen and ammonia in an aqueous system at a mole ratio of ammonia to acid or anhydride of from 1.0:1 to 1.2:1, at a temperature of from about 200* to about 300*C, at a pressure of from about 1,000 to about 3,000 psig, for a time of about 0.5 to about 8 hours, and in the presence of a catalyst of palladium supported on carbon.

    Abstract translation: 一种制备2-吡咯烷酮的方法，其包括使马来酸或马来酸酐与水和氨在氨水与酸或酸酐的摩尔比为1.0:1至1.2:1的水系中以约200的温度反应 在约1000至约3,000psig的压力下进行约0.5至约8小时的时间，并在负载在碳上的钯催化剂存在下进行。

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