公开(公告)号：US5017480A

公开(公告)日：1991-05-21

申请号：US211268

申请日：1988-06-24

申请人： Shigenori Mori ,  Kinzo Iitani ,  Masaki Yamamoto ,  Masashi Miyazawa ,  Toyokazu Kaneko ,  Tetsuya Kaneko ,  Ken-ich Yarita

发明人： Shigenori Mori ,  Kinzo Iitani ,  Masaki Yamamoto ,  Masashi Miyazawa ,  Toyokazu Kaneko ,  Tetsuya Kaneko ,  Ken-ich Yarita

IPC分类号： C12P13/04 ,  B01D61/14 ,  C07C67/00 ,  C07C227/00 ,  C07C227/28 ,  C07C227/40 ,  C07C229/00 ,  C07C231/00 ,  C07C231/24 ,  C07C237/06 ,  C07D209/20 ,  C07D233/64

CPC分类号： B01D61/14 ,  C07C227/00 ,  C07C227/28 ,  C07C227/40 ,  C07C229/00 ,  C07C231/00 ,  C07C231/24 ,  C07C237/06 ,  C07C67/00 ,  C07D209/20 ,  C07D233/64 ,  C12P13/04

摘要： A process for recovering a high-purity L-amino acid from a fermentation liquor obtained by fermentation or an enzymic method, which comprises removing the impurities contained in said fermentation liquor by passing said fermentation liquor through an ultrafilter membrane and then through an ion-exchange or adsorbent resin; concentrating or cooling the effluent thus obtained to result in crystallization of said L-amino acid, and isolating said crystalline L-amino acid from said fermentation liquor.

摘要翻译： 从通过发酵或酶法获得的发酵液中回收高纯度L-氨基酸的方法，其包括通过使所述发酵液通过超滤膜然后通过离子交换来除去所述发酵液中所含的杂质 或吸附树脂; 浓缩或冷却由此获得的流出物导致所述L-氨基酸的结晶，并从所述发酵液中分离所述结晶L-氨基酸。

公开(公告)号：US4936999A

公开(公告)日：1990-06-26

申请号：US214564

申请日：1988-07-01

申请人： Phillip L. Mattison ,  Ronald P. Wirth ,  Michael J. Virnig ,  LeRoy Krbechek

发明人： Phillip L. Mattison ,  Ronald P. Wirth ,  Michael J. Virnig ,  LeRoy Krbechek

IPC分类号： B01D61/14 ,  B01D61/16 ,  B01D61/24 ,  C07C67/00 ,  C07C227/00 ,  C07C227/28 ,  C07C227/40

CPC分类号： C07C227/40

摘要： Disclosed is a process for recovery of amino acids from aqueous mixtures. In particular, it relates to a treatment of said amino acid containing aqueous mixture prior to extraction of the amino acid with a water immiscible organic solution containing a water insoluble extractant for said amino acid. The overall process of the invention which includes the pretreatment and extraction, also includes optional methods of recovering said extracted amino acid from the water immiscible organic solution. Accordingly, the invention also relates to a process for recovery of the amino acid by stripping of the amino acid from the organic solution and precipitation of the amino acid.

摘要翻译： 公开了从含水混合物中回收氨基酸的方法。 特别地，本发明涉及在用含有用于所述氨基酸的水不溶性萃取剂的水不混溶有机溶液萃取氨基酸之前处理所述含氨基酸的含水混合物。 包括预处理和提取的本发明的整个方法还包括从水不混溶的有机溶液中回收所述提取的氨基酸的任选方法。 因此，本发明还涉及通过从有机溶液中汽提氨基酸和氨基酸的沉淀来回收氨基酸的方法。

公开(公告)号：US4894476A

公开(公告)日：1990-01-16

申请号：US188819

申请日：1988-05-02

申请人： Donald E. Butler ,  Barbara J. Greenman

发明人： Donald E. Butler ,  Barbara J. Greenman

IPC分类号： A61K31/195 ,  A61P25/00 ,  A61P25/08 ,  C07C227/16 ,  C07C227/40 ,  C07C229/28

CPC分类号： C07C229/28 ,  C07C2101/14

摘要： A novel crystalline form of gabapentin and a novel processes for the small and large scale preparations of the anticonvulsant compound in a highly pure state is disclosed. This novel hydrate is produced by a cost effective process which provides an additional purification stage.

公开(公告)号：US4891137A

公开(公告)日：1990-01-02

申请号：US319208

申请日：1989-03-03

申请人： Andre Nohl ,  Ronald V. Perkins

发明人： Andre Nohl ,  Ronald V. Perkins

IPC分类号： B01D61/24 ,  C07C227/40 ,  G01N1/34 ,  G01N30/02 ,  G01N30/06

CPC分类号： B01D61/246 ,  C07C227/40 ,  G01N1/34 ,  G01N2001/4016 ,  G01N2030/027 ,  G01N30/06

摘要： A process removes FMOC--OH which is an undesirable by-product of the derivatization of amino acids by FMOC. The process uses a silicone rubber membrane extractor cell. The sample containing the FMOC--OH is held in a silicone rubber tubing, while pentane flows past the outside of the tube; the FMOC--OH is thus extracted from the sample into the pentane. The process is integrated into a conventional high performance liquid chromatography system and is readily automated.

摘要翻译： 一种方法除去FMOC-OH，这是FMOC对氨基酸的衍生作用的不利副产物。 该方法使用硅橡胶膜提取器。 含有FMOC-OH的样品保持在硅橡胶管中，而戊烷流过管的外部; 因此FMOC-OH从样品中提取到戊烷中。 该方法被整合到常规的高效液相色谱系统中并且容易自动化。

公开(公告)号：US4740615A

公开(公告)日：1988-04-26

申请号：US924393

申请日：1986-10-29

申请人： James W. McManus ,  Larry D. Forshey

发明人： James W. McManus ,  Larry D. Forshey

IPC分类号： C07C229/36 ,  C07C227/40 ,  C07C99/12

CPC分类号： C07C227/40 ,  C07C229/36

摘要： A process for the recovery in substantially pure form of an amino acid represented by the formula ##STR1## from an aqueous production mixture by a low pressure temperature gradient chromatographic process is described.

公开(公告)号：US4734401A

公开(公告)日：1988-03-29

申请号：US840307

申请日：1986-03-17

申请人： John J. Blouin

发明人： John J. Blouin

IPC分类号： A61K9/00 ,  A61K9/14 ,  C07C67/00 ,  C07C227/00 ,  C07C227/40 ,  C12P13/04 ,  A23B4/04 ,  A61K9/10 ,  A61K37/02

CPC分类号： A61K9/14

摘要： A process is disclosed whereby a depyrogenated solution comprising one or more amino acids is converted to a dried, amorphous product by spray drying. The solution optionally may contain one or more additional components, such as salts, buffers, lipids, vitamins, trace elements and electrolytes. Products may be prepared according to this method which are suitable for enteral or parenteral nutritive therapeutic use.

摘要翻译： 公开了一种方法，其中包含一种或多种氨基酸的去羟基化溶液通过喷雾干燥转化成干燥的无定形产物。 溶液任选地可以含有一种或多种另外的组分，例如盐，缓冲液，脂质，维生素，微量元素和电解质。 产品可根据本方法制备，适用于肠内或肠外营养治疗。

公开(公告)号：US4605477A

公开(公告)日：1986-08-12

申请号：US704596

申请日：1985-02-25

申请人： Masaharu Doya ,  Toshio Kondo ,  Hideo Igarashi ,  Takako Uchiyama

发明人： Masaharu Doya ,  Toshio Kondo ,  Hideo Igarashi ,  Takako Uchiyama

IPC分类号： C07C319/28 ,  C07C67/00 ,  C07C227/00 ,  C07C227/40 ,  C07C229/02 ,  C07C313/00 ,  C07C323/58 ,  C12P13/04 ,  B01D13/02

CPC分类号： B01D61/44 ,  C12P13/04 ,  B01D2311/2623

摘要： An .alpha.-amino acid is effectively separated and recovered from an aqueous solution containing at least an .alpha.-amino acid and its corresponding .alpha.-amino acid amide by performing ion-exchange electrodialysis in the presence of ammonia. A reaction product liquid obtained by biochemical asymmetric hydrolysis of a D, L-.alpha.-amino acid is used preferably as the raw material aqueous solution for dialysis.

摘要翻译： 通过在氨的存在下进行离子交换电渗析，从含有至少α-氨基酸及其相应的α-氨基酰胺的水溶液中有效地分离和回收α-氨基酸。 优选使用通过D，L-α-氨基酸的生物化学不对称水解获得的反应产物作为用于透析的原料水溶液。

公开(公告)号：US4554376A

公开(公告)日：1985-11-19

申请号：US659861

申请日：1984-10-11

申请人： Teruo Fujimoto ,  Yoshinobu Isono ,  Yoshiyuki Miyaki

发明人： Teruo Fujimoto ,  Yoshinobu Isono ,  Yoshiyuki Miyaki

IPC分类号： B01J43/00 ,  B01J39/20 ,  B01J41/12 ,  B01J47/12 ,  C07C67/00 ,  C07C227/00 ,  C07C227/40 ,  C07C229/00 ,  C07C229/02 ,  C07C99/12

CPC分类号： C07C227/40

摘要： This is a method for separating or purifying an amino acid from a mixture including other substance such as an inorganic salt other than the amino acid and/or a mutual mixture of amino acids including the amino acid by means of piezo-dialysis employing an amphoteric ion exchange membrane. This membrane is made from a ternary block copolymer having a molecular structure of straight chain in which first macro-molecule with a cation exchange group, second macromolecule with an anion exchange group and third macromolecule without ion exchange group are linked together.

摘要翻译： 这是从包含氨基酸以外的其他物质，除氨基酸以外的无机盐和/或包含氨基酸的氨基酸的相互混合物的混合物中分离或纯化氨基酸的方法，通过使用两性离子的压电透析 交换膜。 该膜由具有阳离子交换基团的第一大分子，阴离子交换基团的第二大分子和没有离子交换基团的第三高分子连接在一起的具有直链分子结构的三元嵌段共聚物制成。

公开(公告)号：US4111714A

公开(公告)日：1978-09-05

申请号：US675014

申请日：1976-04-08

申请人： Hermann Hippchen ,  Hans-Georg Schneider ,  Renate Schwingeler

发明人： Hermann Hippchen ,  Hans-Georg Schneider ,  Renate Schwingeler

IPC分类号： C07C227/28 ,  C07C67/00 ,  C07C227/00 ,  C07C227/40 ,  C13B20/14 ,  C13D3/14 ,  C07C59/12 ,  C07C59/16 ,  C07C99/12

CPC分类号： C13B20/14

摘要： To recover amino acids from raw sugar juice, as obtained in beet extraction, the juice is treated with acid or with lime to coagulate impurities which are separated off. The juice may be treated before or after coagulation with a pectin-cleaving enzyme. The juice so pretreated can be directly passed through a strong cation exchanger and a weak anion exchanger whereby the amino acids are adsorbed. Switchover to a new cation exchanger is initiated when betaine flows out the column. Elution is effected, preferably with an ammonium compound, and eluate is collected, preferably each fraction being enriched in a different amino acid. The sugar juice may be concentrated and crystallized in known manner and is of comparatively high purity.

公开(公告)号：US4048224A

公开(公告)日：1977-09-13

申请号：US664328

申请日：1976-03-05

申请人： John M. Chemerda ,  George Gal

发明人： John M. Chemerda ,  George Gal

IPC分类号： C07C227/34 ,  A61K31/195 ,  A61K31/198 ,  A61P31/04 ,  C07C20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/06 ,  C07C227/36 ,  C07C227/40 ,  C07C229/08 ,  C07C229/20 ,  C07C101/10

CPC分类号： C07C51/487

摘要： DL-Alanine, 3-fluoro-DL-alanine and 2-deutero-3-fluoro-DL-alanine, are resolved by reaction with a resolving base and a .beta.-dicarbonyl compound. The resulting azomethine diastereomeric salts which are easily separated, the masking group is readily removed under mildly acidic conditions.

摘要翻译： DL-丙氨酸，3-氟-DL-丙氨酸和2-氘-3-氟-DL-丙氨酸通过与拆分碱和β-二羰基化合物的反应来分解。 所得的偶氮甲碱非对映体盐易于分离，掩蔽基团在轻度酸性条件下容易除去。