Cyclic compound, its metal complex and modified metal complex
    91.
    发明授权
    Cyclic compound, its metal complex and modified metal complex 有权
    环状化合物,其金属络合物和改性金属络合物

    公开(公告)号:US09236613B2

    公开(公告)日:2016-01-12

    申请号:US13969772

    申请日:2013-08-19

    摘要: A compound represented by formula (1): wherein Y1 to Y4 each independently represent any one of the following groups: in which Rα represents a hydrogen atom or a monovalent hydrocarbon group; P1 to P4 each independently represents a group of atoms necessary for forming a heterocyclic ring together with each Y1 to Y4 and the two carbon atoms adjacent to Y1 to Y4, respectively; P5 and P6 each independently represents a group of atoms necessary for forming a cyclic skeleton together with the carbon atom to which Z1 bonds or Z2 bonds; P1 and P2, P2 and P6, P6 and P4, P4 and P3, P3 and P5, and P5 and P1 may further combine with each other to form a ring; Q1 and Q2 each independently represents a connecting group or a direct binding; and Z1 and Z2 each independently represent any one of the following groups; —NRβ2, —ORβ, —SRβ, —PRβ2 in which Rβ represents a hydrogen atom or a monovalent hydrocarbon group, and when plural Rβs are present, these plural Rβs may be the same or different from each other.

    摘要翻译: 由式(1)表示的化合物:其中Y 1至Y 4各自独立地表示以下基团中的任一个:其中Rα表示氢原子或一价烃基; P1至P4各自独立地表示与Y1至Y4和Y1至Y4相邻的两个碳原子一起形成杂环所需的一组原子团; P5和P6各自独立地表示与Z1键或Z2键的碳原子一起形成环状骨架所需的原子团; P1和P2,P2和P6,P6和P4,P4和P3,P3和P5,P5和P1可以进一步组合形成环; Q1和Q2各自独立地表示连接基团或直接结合; Z1和Z2各自独立地表示以下基团中的任何一个; -NR&bgr; 2,-OR&bgr; -SR&bgr; -PR&bgr; 2其中R&bgr; 表示氢原子或一价烃基,当存在多个R b时,这些多个R a可相同或不同。

    Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
    95.
    发明授权
    Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them 有权
    吲哚和苯并呋喃稠合的亚奎宁衍生物及其制备方法

    公开(公告)号:US09150584B2

    公开(公告)日:2015-10-06

    申请号:US13749593

    申请日:2013-01-24

    申请人: DemeRx, Inc.

    IPC分类号: C07D491/22 C07D471/22

    摘要: Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (−) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms.

    摘要翻译: 本文提供的是吲哚和苯并呋喃稠合的亚奎宁衍生物。 本文还提供用于制备此类衍生物的方法,优选对映选择性方法,包括以基本上对映体纯的形式制备( - )和(+)诺布恩或其盐的方法。

    Metal complex, modified compound thereof and useful compound thereof
    98.
    发明授权
    Metal complex, modified compound thereof and useful compound thereof 有权
    金属络合物,其改性化合物及其有用化合物

    公开(公告)号:US09130233B2

    公开(公告)日:2015-09-08

    申请号:US13823257

    申请日:2011-09-14

    摘要: Provided is a compound including residues derived from a compound represented by Formula (1) and a divalent aromatic group, wherein the number of the residues is 2 to 4, the number of the divalent aromatic group is 1 to 3, and the sum of the numbers of the residues and the divalent aromatic group is 3 to 5. In Formula (1), each of Y1 to Y4 represent a group represented by any of the following Formula (2); in the following Formula (2), Rα represents a hydrogen atom or a hydrocarbyl group; each of P1 to P4 represents an atomic group forming a heterocyclic ring containing Y1 to Y4; P5 and P6 represent an atomic group forming an aromatic ring or a heterocyclic ring; Q1 and Q2 represent a linking group or a direct bond; and Z1 and Z2 represent a hydrogen atom or a group represented by any of the following Formula (3); and in the following Formula (3), Rβ represents a hydrogen atom or a hydrocarbyl group.

    摘要翻译: 本发明提供一种化合物,其包括由式(1)表示的化合物和二价芳族基团的残基,其中残基数为2〜4,二价芳香族基团的数量为1〜3, 残基和二价芳基的数目为3〜5。式(1)中,Y 1〜Y 4分别表示由下述式(2)表示的基团。 在下式(2)中,Rα表示氢原子或烃基; P1〜P4各自表示形成含有Y 1〜Y 4的杂环的原子团; P5和P6表示形成芳环或杂环的原子团; Q1和Q2表示连接基团或直接键; Z 1和Z 2表示氢原子或由下式(3)中的任一个表示的基团。 在下式(3)中,R&bgr; 表示氢原子或烃基。