公开(公告)号：US09685250B2

公开(公告)日：2017-06-20

申请号：US14476601

申请日：2014-09-03

申请人： Korea Atomic Energy Research Institute

发明人： Sung-Hee Jung ,  Sun Ju Choi ,  Jong Bum Kim ,  Jin Ho Moon ,  Seong Ho Choi ,  Sang Ei Seo

IPC分类号： G21G1/00 ,  G21H5/02 ,  G21G1/08

CPC分类号： G21H5/02 ,  G21G1/08

摘要： A method of preparing radioisotope hybrid nanocomposite particles using a sol-gel reaction, and radioisotope hybrid nanocomposite particles prepared using the same are provided. The method includes preparing a complex precursor using a metal ion and an unshared electron pair reactive compound, growing hybrid nanocomposite particles based on the complex precursor by means of a sol-gel reaction, calcining the nanocomposite particles in the air to remove organic matters present in the nanocomposite particles, and irradiating the nanocomposite particles with neutrons to prepare radioisotope hybrid nanocomposite particles. The radioisotope nanocomposite particles prepared using the method can be used as diagnostic and therapeutic particles in the fields of oil refining, chemistry, cement, agriculture, water resources, environment, ocean, and medicine, and can also be used as a radioisotope tracer for evaluating the risk of nanomaterials.

公开(公告)号：US09449726B2

公开(公告)日：2016-09-20

申请号：US14293599

申请日：2014-06-02

申请人： Washington University

发明人： Vernal Richards ,  Suzanne Lapi

IPC分类号： G21G1/00 ,  C01B31/34 ,  A61K51/04

CPC分类号： G21G1/001 ,  A61K51/0489 ,  C01B32/949 ,  G21G2001/0036 ,  G21G2001/0042

摘要： Methods of synthesizing 100Mo2C and 99mTcO4− are disclosed. Methods of 100Mo2C generation involve thermally carburizing 100MoO3. Methods of 99mTcO4 generation involve proton bombardment of 100Mo2C in a cyclotron. Yields of 99mTcO4 can be increased by sintering 100Mo2C prior to bombardment. The methods also include recycling of 100Mo2C to form 100MoO3. SPECT images obtained using 99mTcO4 generated by the disclosed methods are also presented.

摘要翻译： 公开了合成100Mo2C和99mTcO4-的方法。 100Mo2C生成方法涉及100MoO3的热渗碳。 99mTcO4生成的方法涉及回旋加速器中100Mo2C的质子轰击。 在轰击前烧结100Mo2C可以提高99mTcO4的产率。 这些方法还包括回收100Mo2C以形成100MoO3。 还提出了通过公开的方法产生的使用99mTcO4获得的SPECT图像。

公开(公告)号：US09396826B2

公开(公告)日：2016-07-19

申请号：US13192300

申请日：2011-07-27

申请人： Steven Richard Reese ,  Todd Stephen Palmer ,  Stephen Todd Keller ,  Madicken Munk

发明人： Steven Richard Reese ,  Todd Stephen Palmer ,  Stephen Todd Keller ,  Madicken Munk

IPC分类号： G21G1/00 ,  G21G1/02 ,  G21K5/08

CPC分类号： G21G1/02 ,  G21G1/00 ,  G21G2001/0036 ,  G21K5/08

摘要： An isotope production target may include an outer diameter wall and an inner diameter wall. An isotope source may be located between the inner diameter wall and the outer diameter wall, and the isotope source may comprise fissile material interspersed with one or more voided regions. A central region may be located within the inner diameter wall, and the central region may be configured to house a neutron thermalization volume.

摘要翻译： 同位素生产目标可以包括外径壁和内径壁。 同位素源可以位于内径壁和外径壁之间，同位素源可以包括散布有一个或多个空隙区域的裂变材料。 中心区域可以位于内径壁内，并且中心区域可以被配置为容纳中子热化体积。

公开(公告)号：US20160148712A1

公开(公告)日：2016-05-26

申请号：US14942709

申请日：2015-11-16

申请人： GARY M. SANDQUIST

发明人： GARY M. SANDQUIST

IPC分类号： G21G1/00 ,  G21F3/00

CPC分类号： G21G1/001 ,  G21G1/06 ,  G21G2001/0036

摘要： The present disclosure generally relates to methods and structures for the production of radioisotopes from the thermal neutron irradiation of selected natural isotopes. The methods, structures and operations are applicable to the production of any radioisotope that may be produced from neutron irradiation.

摘要翻译： 本公开一般涉及用于从所选择的天然同位素的热中子照射产生放射性同位素的方法和结构。 方法，结构和操作适用于生产可由中子照射产生的任何放射性同位素。

公开(公告)号：US20160141061A1

公开(公告)日：2016-05-19

申请号：US14727528

申请日：2015-06-01

申请人： Eric A. Burgett

发明人： Eric A. Burgett

IPC分类号： G21G1/00 ,  G21G1/10

CPC分类号： G21G1/001 ,  G21G1/10 ,  G21G2001/0042

摘要： The present invention relates generally to a system and method for producing Technetium-99m. More specifically, the present invention relates to a novel method and device for modifying commercially-available, widely-used low energy positron emission tomography (PET) cyclotrons in order to produce Technetium-99m in a more efficient, less expensive manner that previously known.

摘要翻译： 本发明一般涉及生产锝-99m的系统和方法。 更具体地说，本发明涉及用于改进市售的广泛使用的低能正电子发射断层扫描（PET）回旋加速器以便以先前已知的更有效，更便宜的方式生产锝-99m的新方法和装置。

公开(公告)号：US20160111176A1

公开(公告)日：2016-04-21

申请号：US14949665

申请日：2015-11-23

申请人： UCHICAGO ARGONNE, LLC

发明人： Jerry A. Nolen, JR. ,  Itacil C. Gomes

IPC分类号： G21G1/00

CPC分类号： G21G1/001 ,  G21G1/10 ,  G21G2001/0084 ,  G21G2001/0089 ,  G21G2001/0094

摘要： The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope 225Ac is produced via the nuclear reaction (p,2p6n),whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a 232Th target nucleus. Another medically important isotope 213Bi is then available as a decay product. The production of highly purified 211At is also provided.

摘要翻译： 本发明提供了一种使用来自加速器的颗粒束来生产同位素的方法，由此将梁保持在约70至2000MeV之间; 并使含钍靶与颗粒接触。 通过核反应（p，2p6n）产生医学上重要的同位素225Ac，由此，高能质子使得从232Th靶核导致2个质子和6个中子的喷射。 另一种医学上重要的同位素213Bi则可以作为衰变产物。 还提供了高纯度的211At的生产。

公开(公告)号：US09240253B2

公开(公告)日：2016-01-19

申请号：US12755714

申请日：2010-04-07

申请人： Jennifer Varnedoe ,  William Earl Russell, II ,  Bradley D. Bloomquist ,  Melissa Allen ,  James Edward Paine ,  Alan Anthony Alvarez

发明人： Jennifer Varnedoe ,  William Earl Russell, II ,  Bradley D. Bloomquist ,  Melissa Allen ,  James Edward Paine ,  Alan Anthony Alvarez

IPC分类号： A61K51/02 ,  B01D15/14 ,  B01D15/18 ,  B01D15/22 ,  C22B34/12 ,  C22B34/34 ,  G01N30/60 ,  G21G1/00

CPC分类号： G21G1/0005 ,  A61K51/025 ,  B01D15/14 ,  B01D15/18 ,  B01D15/22 ,  C22B34/12 ,  C22B34/34 ,  G01N30/6052 ,  G01N30/6065 ,  G21G2001/0042

摘要： At least one system for eluting a radioactive material and a method of eluting a radioactive material is provided. The system for eluting a radioactive material may include an elution column configured to enclose an radioactive material, a first sealing member sealing a first end of the elution column, a second sealing member sealing a second end of the elution column, an elution supply source connected to the first end of the elution column via a first needle, a collection system connected to the second end of the elution column via a second needle, and a filter in the elution column, the filter being configured to support the radioactive material and prevent the radioactive material from contacting the second needle.

摘要翻译： 提供至少一种用于洗脱放射性物质的系统和一种洗脱放射性物质的方法。 用于洗脱放射性物质的系统可以包括被配置为包围放射性物质的洗脱塔，密封洗脱塔的第一端的第一密封构件，密封洗脱塔的第二端的第二密封构件，连接的洗脱供应源 通过第一针，经由第二针连接到洗脱塔的第二端的收集系统和洗脱塔中的过滤器，洗涤塔的第一端，所述过滤器被配置为支撑放射性物质并防止 与第二针接触的放射性物质。

公开(公告)号：US09202600B2

公开(公告)日：2015-12-01

申请号：US11814035

申请日：2006-01-16

申请人： Helge Leif Ravn ,  Gerd Juergen Beyer ,  Ulli Koester ,  Jacques Lettry ,  Richard Catherall ,  Alexander Hohn ,  Joerg Neuhausen ,  Luca Zanini ,  Andreas Tuerler

发明人： Helge Leif Ravn ,  Gerd Juergen Beyer ,  Ulli Koester ,  Jacques Lettry ,  Richard Catherall ,  Alexander Hohn ,  Joerg Neuhausen ,  Luca Zanini ,  Andreas Tuerler

IPC分类号： A61K51/00 ,  A61M36/14 ,  G21G1/00 ,  G21G1/10

CPC分类号： G21G1/001 ,  G21G1/00 ,  G21G1/10

摘要： The present invention relates to an universal method for the large scale production of high-purity carrier free or non carrier added radioisotopes by applying a number of “unit operations” which are derived from physics and material science and hitherto not used for isotope production. A required number of said unit operations is combined, selected and optimized individually for each radioisotope production scheme. The use of said unit operations allows a batch wise operation or a fully automated continuous production scheme. The radioisotopes produced by the inventive method are especially suitable for producing radioisotope-labelled bioconjugates as well as particles, in particular nanoparticles and microparticles.

摘要翻译： 本发明涉及通过应用从物理和材料科学得到的迄今为止不用于同位素生产的许多“单元操作”大规模生产高纯载体或非载体的放射性同位素的通用方法。 对于每个放射性同位素生产方案，所需数量的所述单元操作被组合，选择和优化。 使用所述单元操作允许分批操作或全自动连续生产方案。 通过本发明方法产生的放射性同位素特别适用于制备放射性同位素标记的生物共轭物以及颗粒，特别是纳米颗粒和微粒。

公开(公告)号：US09177679B2

公开(公告)日：2015-11-03

申请号：US13026102

申请日：2011-02-11

申请人： Jerry A. Nolen, Jr. ,  Itacil C. Gomes

发明人： Jerry A. Nolen, Jr. ,  Itacil C. Gomes

IPC分类号： G21G1/06 ,  G21G1/08 ,  G21G1/00 ,  G21G1/10

CPC分类号： G21G1/08 ,  G21G1/00 ,  G21G1/10 ,  G21G2001/0036

摘要： The invention provides a method using accelerators to produce radio-isotopes in high quantities. The method comprises: supplying a “core” of low-enrichment fissile material arranged in a spherical array of LEU combined with water moderator. The array is surrounded by substrates which serve as multipliers and moderators as well as neutron shielding substrates. A flux of neutrons enters the low-enrichment fissile material and causes fissions therein for a time sufficient to generate desired quantities of isotopes from the fissile material. The radio-isotopes are extracted from said fissile material by chemical processing or other means.

摘要翻译： 本发明提供一种使用加速器来大量生产放射性同位素的方法。 该方法包括：提供一种低浓度易裂变材料的“核心”，排列成LEU与水调节剂结合的球形阵列。 该阵列被用作乘法器和调节器以及中子屏蔽衬底的衬底包围。 中子通量进入低浓度易裂变材料，并在其中引起足够的时间，从裂变材料产生所需量的同位素。 通过化学处理或其他手段从所述裂变材料中提取放射性同位素。

公开(公告)号：US09165691B2

公开(公告)日：2015-10-20

申请号：US12385747

申请日：2009-04-17

申请人： William Earl Russell, II ,  Christopher J. Monetta ,  Lukas Trosman

发明人： William Earl Russell, II ,  Christopher J. Monetta ,  Lukas Trosman

IPC分类号： G21C3/00 ,  G21G1/02 ,  G21C7/04 ,  G21G1/00

CPC分类号： G21G1/02 ,  G21C7/04 ,  G21G1/001 ,  G21G2001/0094 ,  Y02E30/39

摘要： Example embodiments are directed to materials useable as burnable poisons in nuclear reactors, components using the same, and methods of using the same. Example embodiment burnable poison materials produce desired daughter products as they burn out, thereby permitting placement and use for neutronic characteristic improvement and/or neutron flux shielding in locations conventionally barred as uneconomical. Example embodiment burnable poison materials may include natural iridium and enriched iridium-193. Example embodiment components may be fabricated, shaped, and placed to provide desired burnable poison effects in the reactor core in conventional locations and locations not conventionally used due to economic infeasibility. Example methods include use of example embodiment components, including determining locations benefiting from burnable poison effects, fabricating example embodiment components of a desired amount of example embodiment burnable poison materials, placing the example embodiment components, exposing example embodiment components to flux within the operating nuclear reactor, removing and harvesting example embodiment burnable poison components for desired daughter products produced from example embodiment burnable poison materials.

摘要翻译： 示例性实施方案涉及可用作核反应堆中的可燃毒物的材料，使用其的组分及其使用方法。 示例性实施例可燃毒物材料在燃烧时产生所需的女性产品，从而允许在通常被禁止作为不经济的位置的位置中放置和使用中和特性改进和/或中子通量屏蔽。 示例性的可燃烧毒物可包括天然铱和富集铱-193。 可以制造，成形和放置示例性实施例部件，以在由于经济不可行性而不常规使用的常规位置和位置的反应堆芯中提供所需的可燃毒物效应。 示例性方法包括使用示例实施例部件，包括确定受益于可燃毒性作用的位置，制造所需数量的示例性实施例的可燃毒物材料的示例性实施例部件，放置示例性实施例部件，将示例性实施例部件暴露于操作核反应堆 ，从示例性实施方案可燃毒物材料制备的期望的女性产品中去除和收获示例性实施例的可燃毒物成分。