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公开(公告)号：US20160111176A1
公开(公告)日：2016-04-21
申请号：US14949665
申请日：2015-11-23
IPC分类号： G21G1/00
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0084 , G21G2001/0089 , G21G2001/0094
摘要： The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope 225Ac is produced via the nuclear reaction (p,2p6n),whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a 232Th target nucleus. Another medically important isotope 213Bi is then available as a decay product. The production of highly purified 211At is also provided.
摘要翻译： 本发明提供了一种使用来自加速器的颗粒束来生产同位素的方法，由此将梁保持在约70至2000MeV之间; 并使含钍靶与颗粒接触。 通过核反应（p，2p6n）产生医学上重要的同位素225Ac，由此，高能质子使得从232Th靶核导致2个质子和6个中子的喷射。 另一种医学上重要的同位素213Bi则可以作为衰变产物。 还提供了高纯度的211At的生产。
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2.发明申请公开(公告)号：US20180047474A1
公开(公告)日：2018-02-15
申请号：US15675529
申请日：2017-08-11
发明人： Matthew J. O'Hara
CPC分类号： G21G4/08 , A61K51/00 , A61K51/1289 , B01J20/06 , C01B23/0073 , C01G21/00 , G21G1/0005 , G21G4/10 , G21G2001/0084 , G21G2001/0094
摘要： An isotope production system, emanation generator, and process are disclosed for production of high-purity radioisotopes. In one implementation example, high-purity Pb-212 and/or Bi-212 isotopes are produced suitable for therapeutic applications. In one embodiment the process includes transporting gaseous radon-220 from a radium-224 bearing generator which provides gas-phase separation of the Rn-220 from the Ra-224 in the generator. Subsequent decay of the captured Rn-220 accumulates high-purity Pb-212 and/or Bi-212 isotopes suitable for direct therapeutic applications. Other high-purity product isotopes may also be prepared.
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3.发明授权
公开(公告)号：US6126909A
公开(公告)日：2000-10-03
申请号：US230635
申请日：1999-01-28
CPC分类号： G21G1/001 , A61K51/1282 , G21G1/0005 , G21G2001/0084
摘要： A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carving out this process and a process for the therapeutic use thereof are also disclosed.
摘要翻译： PCT No.PCT / US97 / 14994 Sec。 371日期1999年1月28日 102（e）1999年1月28日PCT PCT 1997年8月26日PCT公布。 公开号WO98 / 08481 日期：1998年3月5日公开了一种生产基本上不含杂质的Bi-212的方法。 将含有Pb-212的酸性进料溶液与萃取介质接触以将Pb-212与其结合。 萃取介质用第二酸溶液冲洗以除去杂质，留下基本上无杂质的含Pb-212的萃取介质Pb-212在萃取介质上生长，通过放射性衰变形成Bi-212。 然后用酸溶液从萃取介质中洗脱Bi-212，以形成基本上不含杂质的Bi-212酸溶液。 还公开了一种用于雕刻该方法的设备及其治疗用途的方法。
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公开(公告)号：US09202602B2
公开(公告)日：2015-12-01
申请号：US13025079
申请日：2011-02-10
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0084 , G21G2001/0089 , G21G2001/0094
摘要： The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope 225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a 232Th target nucleus. Another medically important isotope 213Bi is then available as a decay product. The production of highly purified 211At is also provided.
摘要翻译： 本发明提供了一种使用来自加速器的颗粒束来生产同位素的方法，由此将梁保持在约70至2000MeV之间; 并使含钍靶与颗粒接触。 通过核反应（p，2p6n）产生医学上重要的同位素225Ac，由此，高能质子使得从232Th靶核导致2个质子和6个中子的喷射。 另一种医学上重要的同位素213Bi则可以作为衰变产物。 还提供了高纯度的211At的生产。
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公开(公告)号：US20130220928A1
公开(公告)日：2013-08-29
申请号：US13707824
申请日：2012-12-07
发明人： Steve OELSNER
CPC分类号： B01J20/3021 , B01D15/20 , B01D15/203 , B01J20/06 , B01J20/08 , B01J20/103 , B01J20/282 , B01J20/283 , B01J20/284 , B02C23/08 , G21G1/001 , G21G2001/0021 , G21G2001/0031 , G21G2001/0042 , G21G2001/0057 , G21G2001/0073 , G21G2001/0084
摘要： A method of treating an adsorbent for a chromatographic separation. The method involves sonicating particles of an inorganic metal oxide having fragile edges in the absence of any alkylating or acylating agent to form smoothened particles of the inorganic metal oxide and washing the smoothened particles of the inorganic metal oxide to remove fine particulate matter to produce a treated adsorbent. The treated adsorbent can be used in a method of isolating a daughter radioisotope from a daughter radioisotope that is produced from the parent radioisotope by radioactive decay.
摘要翻译： 一种处理吸附剂进行色谱分离的方法。 该方法包括在没有任何烷基化或酰化剂的情况下超声处理具有脆弱边缘的无机金属氧化物的颗粒以形成无机金属氧化物的平滑颗粒并洗涤无机金属氧化物的平滑颗粒以除去细颗粒物质以产生处理过的 吸附剂。 经处理的吸附剂可用于从母体放射性同位素通过放射性衰变产生的子放射性同位素分离子放射性同位素的方法。
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公开(公告)号：US20110200154A1
公开(公告)日：2011-08-18
申请号：US13025079
申请日：2011-02-10
IPC分类号： G21G1/10
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0084 , G21G2001/0089 , G21G2001/0094
摘要： The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope 225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a 232Th target nucleus. Another medically important isotope 213Bi is then available as a decay product. The production of highly purified 211At is also provided.
摘要翻译： 本发明提供了一种使用来自加速器的颗粒束来生产同位素的方法，由此将梁保持在约70至2000MeV之间; 并使含钍靶与颗粒接触。 通过核反应（p，2p6n）产生医学上重要的同位素225Ac，由此，高能质子使得从232Th靶核导致2个质子和6个中子的喷射。 另一种医学上重要的同位素213Bi则可以作为衰变产物。 还提供了高纯度的211At的生产。
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