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    METHOD AND SYSTEM FOR GENERATING TRAINING DATA FOR A MACHINE LEARNING MODEL FOR PREDICTING PERFORMANCE IN ELECTRONIC DESIGN
    101.
    发明申请
    METHOD AND SYSTEM FOR GENERATING TRAINING DATA FOR A MACHINE LEARNING MODEL FOR PREDICTING PERFORMANCE IN ELECTRONIC DESIGN 有权

    公开(公告)号：US20220027536A1

    公开(公告)日：2022-01-27

    申请号：US17296657

    申请日：2019-11-26

    Applicant: Agency for Science, Technology and Research

    Inventor： Rahul Dutta ,  Raju Salahuddin ,  Kevin Tshun Chuan Chai

    IPC: G06F30/27 ,  G06N20/00

    Abstract: There is provided a method of generating training data for a machine learning model for predicting performance in electronic design using at least one processor, the method including: generating a first set of training data based on a first set of input design parameters and an electronic design automation tool; generating a first covariance information associated with the first set of input design parameters based on the first set of training data; determining a second set of input design parameters based on the first covariance information; and generating a second set of training data based on the second set of input design parameters and the electronic design automation tool. There is also provided a corresponding system for generating training data for a machine learning model for predicting performance in electronic design.

    METHOD FOR IDENTIFYING AN UNKNOWN BIOLOGICAL SAMPLE FROM MULTIPLE ATTRIBUTES
    102.
    发明申请
    METHOD FOR IDENTIFYING AN UNKNOWN BIOLOGICAL SAMPLE FROM MULTIPLE ATTRIBUTES 有权

    公开(公告)号：US20220013197A1

    公开(公告)日：2022-01-13

    申请号：US17295418

    申请日：2019-11-20

    Applicant: Agency for Science, Technology and Research

    Inventor： Ian Walsh ,  Katherine Louisa Wongtrakulkish ,  Terry Nguyen-Khuong ,  Pauline Mary Rudd

    IPC: G16C20/70 ,  G16C20/20 ,  G06N20/20 ,  G06N3/08

    Abstract: A method for identifying an unknown biological sample (e.g. a glycan, an antibody, a metabolite) is disclosed. The method comprises: receiving more than two sample measurements for the unknown biological sample, calculating a sample point in a two-dimensional plot from the more than two sample measurements for the unknown biological sample and identifying the unknown biological sample by comparing the sample point against the plurality of reference points in the two-dimensional plot. The two-dimensional plot includes a plurality of stored reference points corresponding to respective known biological compounds. Each reference point is calculated from a plurality of reference measurements for more than two attributes of the corresponding known biological compound (e.g. by performing principal component analysis on the plurality of reference measurements), with each attribute being different from another attribute. Each reference measurement may be obtained experimentally (e.g. by liquid chromatography, mass spectrometry, tandem mass spectrometry, ion mobility spectrometry) or by a machine learning algorithm.

    METHODS FOR MANIPULATING CELL STATE TRANSITIONS IN CANCER
    103.
    发明申请
    METHODS FOR MANIPULATING CELL STATE TRANSITIONS IN CANCER 有权

    公开(公告)号：US20220008358A1

    公开(公告)日：2022-01-13

    申请号：US17293362

    申请日：2019-11-11

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Wai Leong TAM ,  Ser Yue LOO ,  Li Ping TOH

    IPC: A61K31/07 ,  A61K45/06 ,  A61P35/04

    Abstract: The present invention relates to a method of inducing mesenchymal-epithelial transition (MET) in a basal-like (or mesenchymal-like) cancer cell by contacting the cancer cell with an inducer of mesenchymal-epithelial transition for a time and under conditions sufficient to induce MET in the cell. Additionally, there is also provided a method of inhibiting epithelial-mesenchymal transition (EMT) of a cancer in a subject, the method comprising administering an inhibitor or regulator of lipid metabolism for a sufficient time and under conditions to inhibit epithelial mesenchymal transition (EMT) of the cancer in the subject.

    EPIGENOMIC PROFILING REVEALS THE SOMATIC PROMOTER LANDSCAPE OF PRIMARY GASTRIC ADENOCARCINOMA
    107.
    发明申请
    EPIGENOMIC PROFILING REVEALS THE SOMATIC PROMOTER LANDSCAPE OF PRIMARY GASTRIC ADENOCARCINOMA 有权

    公开(公告)号：US20210301348A1

    公开(公告)日：2021-09-30

    申请号：US15999597

    申请日：2017-02-16

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Patrick TAN ,  Aditi QAMRA ,  Manjie XING ,  Wen Fong OOI

    IPC: C12Q1/6886

    Abstract: The present invention relates to a method for determining the presence or absence of at least one promoter in a cancerous biological sample relative to a non-cancerous biological sample. The present invention also relates to a method for determining the prognosis of cancer in a subject, a method for modulating the activity of at least one cancer-associated promoter in a cell, a method for modulating the immune response of a subject to cancer, a method for determining the presence of at least one cancer-associated promoter in a cancerous biological sample relative to a non-cancerous biological sample and a biomarker for detecting cancer in a subject.

    Comparator circuit arrangement and method of forming the same
    108.
    发明授权
    Comparator circuit arrangement and method of forming the same 有权

    公开(公告)号：US11108386B2

    公开(公告)日：2021-08-31

    申请号：US16971226

    申请日：2019-03-11

    Applicant: Agency for Science, Technology and Research

    Inventor： Yoshio Nishida ,  Ravinder Pal Singh

    IPC: H03K5/22 ,  H03K5/24 ,  H03K5/05 ,  H03K5/00

    Abstract: Various embodiments may provide a comparator circuit arrangement. The comparator circuit arrangement may include a preamplifier having a first input configured to be coupled to a first input voltage, a second input configured to be coupled to a second input voltage, and an output configured to generate a preamplifier output signal based on the first input voltage and the second input voltage. The comparator circuit arrangement may also include a switch circuit arrangement coupled to the preamplifier, the switch circuit arrangement configured to deactivate the preamplifier upon the second input voltage exceeding the first input voltage and further configured to activate the preamplifier upon a fall of the second input voltage, and a pull-up circuit arrangement coupled to the output of the preamplifier, the pull-up circuit arrangement configured to provide a boost voltage to the preamplifier output signal for a predetermined duration upon the fall of the second input voltage.

    Optical assembly and method of forming the same
    109.
    发明授权
    Optical assembly and method of forming the same 有权

    公开(公告)号：US11105989B2

    公开(公告)日：2021-08-31

    申请号：US16498891

    申请日：2018-03-28

    Applicant: Agency for Science, Technology and Research

    Inventor： Teck Guan Lim

    IPC: G02B6/42

    Abstract: Various embodiments may provide an optical assembly. The optical assembly may include a substrate with a first and a second grooves, and a photonic integrated circuit chip with a coupling waveguide, a first and a second grooves. The optical assembly may further include a first and a second cylindrical rods held by the respective grooves of the substrate and the photonic integrated circuit chip. A portion of the first rod and a portion of the second rod define a vertical offset between the photonic integrated circuit chip and the substrate to align the coupling waveguide with an optical fiber.

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