公开(公告)号：US06686375B2

公开(公告)日：2004-02-03

申请号：US10107671

申请日：2002-03-26

Applicant: Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishnan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishnan Kapahi

Inventor： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishnan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishnan Kapahi

IPC: A61K3578

CPC classification number: A61K36/27 ,  Y10S514/885 ,  Y10S514/893 ,  Y10S514/894

Abstract: The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of producing said composition and also a method of treating a subject using said composition.

Abstract translation: 本发明涉及可用于肝保护的组合物，所述组合物包含植物Cryptolepis Buchanani的极性提取物和/或所述提取物的级分，以及任选的药学上可接受的添加剂以及制备所述组合物的方法，以及使用 所说的组合。

公开(公告)号：US06677485B2

公开(公告)日：2004-01-13

申请号：US10149624

申请日：2002-08-09

Applicant: Naresh Kumar ,  Bakthavathsalan Vijayaraghavan ,  Kinali Venkata Ramana ,  Swargam Sathyanarayana

Inventor： Naresh Kumar ,  Bakthavathsalan Vijayaraghavan ,  Kinali Venkata Ramana ,  Swargam Sathyanarayana

IPC: C07C21702

CPC classification number: C07C213/06 ,  C07C217/48

Abstract: An improved and industrially advantageous process for the preparation of the antidepressant fluoxetine and its pharmaceutically acceptable salts, preferably hydrochloride.

Abstract translation: 一种用于制备抗抑郁药氟西汀及其药学上可接受的盐，优选盐酸盐的改进和工业上有利的方法。

公开(公告)号：US06649745B2

公开(公告)日：2003-11-18

申请号：US10103644

申请日：2002-03-20

Applicant: Sukhdev Swami Handa ,  Om Prakash Suri ,  Vishwa Nath Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Vikram Bhardwaj ,  Kasturi Lal Bedi ,  Anamika Khajuria ,  Anpurna Kaul ,  Girish G. Parikh ,  Prabhakar Kulhar ,  Ulhas Salunkhe ,  Raman Krishnamurthy

Inventor： Sukhdev Swami Handa ,  Om Prakash Suri ,  Vishwa Nath Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Vikram Bhardwaj ,  Kasturi Lal Bedi ,  Anamika Khajuria ,  Anpurna Kaul ,  Girish G. Parikh ,  Prabhakar Kulhar ,  Ulhas Salunkhe ,  Raman Krishnamurthy

IPC: C07C1328

CPC classification number: A61K31/7048 ,  C07J17/00

Abstract: The present invention relates to a novel oligospirostanoside having the structure 3-0-[&agr;-L-rhamnopyranosyl-(1→2)-&agr;-L-rhamnopyranosyl-(1→4)-0-&bgr;-D-glucopyranosyl]-25(S)-5&bgr;-spirostan-3&bgr;-ol isolated from Asparagus racemosus and to a pharmaceutical composition containing the novel oligospirostanoside and to a method for immunomodulation using said oligospirostanoside by administering a pharmaceutically effective amount of said novel oligospirostanoside.

Abstract translation: 本发明涉及具有3-0- [α-L-鼠李糖吡喃糖基 - （1-> 2）-alpha-L-鼠李糖吡喃糖基 - （1-> 4）-β-D-吡喃葡萄糖基]结构的新型寡螺甾烷基苷， 从日本芦笋分离的-25（S）-5β-螺甾烷-3β-醇，以及含有该新型寡螺甾烷酸苷的药物组合物，以及使用所述寡螺甾烷基苷的免疫调节方法，通过施用药学上有效量的所述新型低聚螺旋状甙。

公开(公告)号：US5070195A

公开(公告)日：1991-12-03

申请号：US490151

申请日：1990-03-07

Applicant: Jag M. Khanna ,  Naresh Kumar ,  Kiran Bala ,  Yatendra Kumar

Inventor： Jag M. Khanna ,  Naresh Kumar ,  Kiran Bala ,  Yatendra Kumar

IPC: C07D205/095 ,  C07D501/00

CPC classification number: C07D501/00 ,  C07D205/095

Abstract: An improved method for preparing 2-chlorosulfinyl azetidine-4-one comprises heating a penicillin sulfoxide ester with an N-chlorohalogenating agent at a temperature of about 75.degree. C. to about 140.degree. in an inert organic solvent, and in the presence of an organic solvent insoluble, strongly basic ion exchange resin. Desirably, the ion exchange resin comprises a styrene-divinyl benzane copolymer which is about 2 to 16% cross-linked and incorporates a quaternary ammonium functionality. Such ion exchange resins are commercially available. The 2-chlorosulfinyl azetidine-4-one which is produced by this method can be cyclized in the presence of a Friedel-Crafts catalysts to afford the 3-exomethylene cepham sulfoxide ester in yields of 80-90%.

Abstract translation: 制备2-氯亚磺酰基氮杂环丁烷-4-酮的改进方法包括在惰性有机溶剂中，在约75℃至约140℃的温度下，用N-氯代卤化剂加热青霉素亚砜酯，并在 有机溶剂不溶，强碱性离子交换树脂。 期望地，离子交换树脂包含交联的约2至16％的苯乙烯 - 二乙烯基苯基共聚物并结合季铵官能团。 这样的离子交换树脂是可商购的。 通过该方法制备的2-氯亚磺酰基氮杂环丁烷-4-酮可以在Friedel-Crafts催化剂存在下环化，得到3-异亚甲基头孢烯亚砜酯，产率为80-90％。

公开(公告)号：US20190138337A1

公开(公告)日：2019-05-09

申请号：US15996522

申请日：2018-06-04

Applicant: SRINIVAS VEGESNA ,  JAYAPRAKASH KUMAR ,  PRAMOD VENKATESH ,  NARESH KUMAR THUKKANI

Inventor： SRINIVAS VEGESNA ,  JAYAPRAKASH KUMAR ,  PRAMOD VENKATESH ,  NARESH KUMAR THUKKANI

IPC: G06F9/455 ,  G06F9/445 ,  G06F16/25 ,  G06F8/61 ,  H04L12/24

Abstract: A computerized method comprising: providing a SaaS-based Platform that provides a DevOPS enabled framework to implement an end to end orchestration of a complex multi-vendor network solution on cloud-computing infrastructure, wherein the SaaS-based platform comprises an orchestrator engine and a deployer module, and wherein the deployer module provides a means to do a one touch deployment of a set of virtual test-beds in a computer network and the cloud-computing infrastructure; installing and configuring a database and queue in each of a plurality of nodes of the computer network; installing and configuring a backend server in each of another plurality of nodes of the computer network; installing and configuring a frontend server in each the other plurality of nodes of the computer network; and installing a service load balancer and configuring each of the set of frontend servers as a backend server.

公开(公告)号：US20140187554A1

公开(公告)日：2014-07-03

申请号：US14118116

申请日：2012-05-16

Applicant: Theodore Mark Kamenecka ,  Patrick R. Griffin ,  Youseung Shin ,  Yuanjun He ,  Anne-Laure Blayo ,  Brent R. Lyda ,  Marcel Koenig ,  Naresh Kumar ,  Thomas Burris

Inventor： Theodore Mark Kamenecka ,  Patrick R. Griffin ,  Youseung Shin ,  Yuanjun He ,  Anne-Laure Blayo ,  Brent R. Lyda ,  Marcel Koenig ,  Naresh Kumar ,  Thomas Burris

IPC: C07D317/50 ,  A61K31/496 ,  C07D295/096 ,  A61K45/06 ,  C07D295/185 ,  A61K31/5375 ,  A61K31/5377 ,  C07D213/36 ,  A61K31/495

CPC classification number: C07D317/50 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/5377 ,  A61K45/06 ,  C07D207/09 ,  C07D209/14 ,  C07D211/22 ,  C07D213/36 ,  C07D213/61 ,  C07D213/64 ,  C07D213/74 ,  C07D213/82 ,  C07D215/12 ,  C07D233/61 ,  C07D277/28 ,  C07D277/64 ,  C07D295/096 ,  C07D295/185 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/24 ,  C07D317/58 ,  C07D319/20 ,  C07D333/20 ,  C07D333/34 ,  C07D401/12

Abstract: The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as RORα, RORβ, or RORγ. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided.

Abstract translation: 本发明提供了视黄酸受体相关的孤儿受体如RORα，ROR和bgr或RORγ的小分子调节剂。 本发明的化合物可以是无效作用于LXR受体或其它核受体或其他生物靶标的有效调节剂。 还提供调节ROR的方法和治疗代谢紊乱，免疫疾病，癌症和中枢神经系统疾病的方法，其中医学指示ROR的调节。

公开(公告)号：US08589908B2

公开(公告)日：2013-11-19

申请号：US11606644

申请日：2006-11-29

Applicant: Sriharsha Mysore Subbakrishna ,  Naresh Kumar Gupta ,  Mohan Kashivasi

Inventor： Sriharsha Mysore Subbakrishna ,  Naresh Kumar Gupta ,  Mohan Kashivasi

IPC: G06F9/445

CPC classification number: G06F8/65

Abstract: An embodiment of the present invention provides a system and method for remotely upgrading the firmware of a target device using wireless technology from the Bluetooth-enabled PC or Laptop to another Bluetooth device e.g., mouse, Keyboard, headset, mobile phone etc. Existing solutions either may not have upgrade capabilities, or may require the use of proprietary cables. An embodiment of the solution proposed here extends the “Connecting without cables” concept of Bluetooth to firmware upgrades. The system comprises a host device for sending the firmware required for upgradation; and a target device containing a first code and a second code wherein said first code identifies details of the firmware; and said second code identifies the completion of the download operation when the firmware is successfully downloaded.

Abstract translation: 本发明的一个实施例提供一种用于使用无线技术将蓝牙功能的PC或笔记本电脑远程升级到另一蓝牙设备（例如鼠标，键盘，耳机，移动电话等）的目标设备的固件的系统和方法。现有的解决方案 可能没有升级功能，或可能需要使用专有电缆。 这里提出的解决方案的一个实施例将蓝牙的“无电缆连接”概念扩展到固件升级。 该系统包括用于发送升级所需的固件的主机设备; 以及包含第一代码和第二代码的目标设备，其中所述第一代码识别固件的细节; 并且所述第二代码在固件被成功下载时识别下载操作的完成。

公开(公告)号：US08586618B2

公开(公告)日：2013-11-19

申请号：US12311473

申请日：2007-10-08

Applicant: Naresh Kumar ,  George Iskander

Inventor： Naresh Kumar ,  George Iskander

IPC: A01N43/36 ,  A61K31/40

CPC classification number: C07D307/58 ,  C07D207/38 ,  C07D405/04 ,  C07D409/04 ,  C07D409/06

Abstract: The present invention provides a compound of formula I and a compound of formula II, methods of use and formulations thereof.

Abstract translation: 本发明提供式I化合物和式II化合物，其用途及其制剂。

公开(公告)号：US20100222393A1

公开(公告)日：2010-09-02

申请号：US12159505

申请日：2006-12-21

Applicant: Naresh Kumar ,  Jaskiran Kaur ,  Venkata P. Palle ,  Beenu Bhatt ,  Shelly Jindal ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

Inventor： Naresh Kumar ,  Jaskiran Kaur ,  Venkata P. Palle ,  Beenu Bhatt ,  Shelly Jindal ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC: A61K31/4439 ,  C07D233/54 ,  A61K31/4164 ,  C07D401/02 ,  A61P11/00 ,  A61P13/00 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10

CPC classification number: C07D233/54 ,  C07D233/14 ,  C07D233/56 ,  C07D233/64 ,  C07D401/12

Abstract: Compounds of Formula (I), wherein represents a single bond when G is —OH and double bond when G is —O; R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl or heteroarylalkyl; R3 is selected from the group selected from hydrogen, hydroxy, alkoxy, alkenyloxy or alkynyloxy; X is selected from oxygen, —NH, —NR (wherein R is alkyl, alkenyl, alkenyl, alkynyl or aryl), sulphur or no atom; Het is heterocyclyl or heteroaryl; n is an integer from 1 to 6; are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and 4 i gastrointestinal systems mediated through muscarinic receptors.

Abstract translation: 式（I）的化合物，当G为-OH时，当G为-O时，表示单键; R 1和R 2独立地选自氢，烷基，烯基，炔基，芳烷基，环烷基，芳基，杂芳基，杂环基，杂环基烷基或杂芳基烷基; R3选自氢，羟基，烷氧基，烯氧基或炔氧基; X选自氧，-NH，-NR（其中R是烷基，烯基，烯基，炔基或芳基），硫或无原子; Het是杂环基或杂芳基; n是1至6的整数; 是毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和4I胃肠系统的各种疾病，以及其它用途。

公开(公告)号：US20100056496A1

公开(公告)日：2010-03-04

申请号：US12439771

申请日：2007-09-04

Applicant: Naresh Kumar ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

Inventor： Naresh Kumar ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

IPC: A61K31/55 ,  C07D223/14 ,  A61P1/00 ,  A61P11/00 ,  A61P3/00

CPC classification number: C07D221/24 ,  C07D209/12 ,  C07D209/14

Abstract: The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The present invention also relates to processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors. Formula (I) or a pharmaceutically accepted salt, pharmaceutically acceptable solvate, enantiomers, diastereomer, polymorph or N-oxide thereof, wherein X is.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备本文所述化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 式（I）或其药学上可接受的盐，药学上可接受的溶剂合物，对映异构体，非对映体，多晶型物或N-氧化物，其中X为。