公开(公告)号：US10465004B2

公开(公告)日：2019-11-05

申请号：US15109173

申请日：2015-01-01

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Benjamin Dekel ,  Naomi Pode-Shakked ,  Orit Harai-Steinberg ,  Michal Mark-Danieli ,  Einav Vax

IPC: C07K16/30 ,  C07K16/28 ,  A61K39/00

Abstract: The invention provides antibodies or an antigen-binding portion thereof, which recognize the human Frizzled 7 receptor. Further, the invention provides methods of using these antibodies for the treatment cancer in a subject.

公开(公告)号：US20190269348A1

公开(公告)日：2019-09-05

申请号：US16290988

申请日：2019-03-04

Applicant: The Medical Research Infrastructure and Health Fund of the Tel aviv Medical Center ,  Ramot at Tel Aviv University Ltd.

Inventor： Mordekhay Medvedovsky ,  Tomer Gazit ,  Talma Hendler ,  Evgeny Tsizin-Goldman ,  Alex Bronstein

IPC: A61B5/06 ,  A61B5/053 ,  A61B5/0484 ,  A61B5/00

Abstract: A diagnostic system includes an array of electrodes, which are coupled to a body surface of a living subject at different, respective positions in proximity to a region of interest within the body. A switched impedance network applies varying loads to the electrodes. A processor is coupled to receive and measure electrical signals from the electrodes as a function of the varying loads, and to analyze the measured signals so as to compute a local electrical characteristic of one or more locations within the region of interest.

公开(公告)号：US20190249984A1

公开(公告)日：2019-08-15

申请号：US16275479

申请日：2019-02-14

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Omri BARLEV ,  Michael GOLUB

IPC: G01B11/25 ,  G02B27/09 ,  G06T7/55

Abstract: Devices and methods for 3D sensing are provided. The device comprising an optical device configured and operable to produce at least one structured light pattern, the optical device comprising a light source unit configured and operable to generate one or more light beams along predetermined one or more optical paths, and a diffractive optical unit accommodated in said one or more optical paths, at the output of said light source unit such that the diffractive optical unit faces the light source unit, the diffractive optical unit being non-periodic and two-dimensional and comprising at least one resonance-domain diffractive optical element configured to create 2D spatially variable pattern in a predetermined operative wavelength range, the diffractive optical unit being thereby configured and operable as a beam shaper for said one or more light beams to thereby create said at least one structured light pattern.

公开(公告)号：US20190200923A1

公开(公告)日：2019-07-04

申请号：US16060038

申请日：2016-12-08

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Vadim KRIVITSKY ,  Marina ZVERZHINETSKY

IPC: A61B5/00 ,  G01N27/414 ,  A61B5/1473 ,  H01L29/16 ,  H01L29/06

CPC classification number: A61B5/4866 ,  A61B5/1473 ,  A61B5/6833 ,  A61B5/6847 ,  B82Y15/00 ,  G01N27/4146 ,  G01N33/5005 ,  H01L23/532 ,  H01L29/06 ,  H01L29/0673 ,  H01L29/16 ,  H01L51/0049 ,  H01L51/0545 ,  H01L51/0558

Abstract: A sensing element comprises a transistor having a gate electrode, a source electrode, a gate electrode and a semiconductor nanostructure connecting between the source and the gate electrodes. The semiconductor nanostructure is modified by a functional moiety covalently attached thereto. A voltage source is connected to the gate electrode. A controller controls a gate voltage applied by the voltage source to the gate electrode such as to reverse a redox reaction occurring when the moiety contacts a redox reactive agent.

公开(公告)号：US20190185854A1

公开(公告)日：2019-06-20

申请号：US16312620

申请日：2017-06-23

Applicant: Massachusetts Institute of Technology ,  Ramot at Tel-Aviv University Ltd.

Inventor： Natalie Artzi ,  João Conde ,  Noam Shomron ,  Avital Gilam

IPC: C12N15/113 ,  A61K47/69 ,  A61K33/243 ,  A61K9/06 ,  A61P35/04 ,  A61K47/62 ,  A61K47/59 ,  A61K47/61 ,  A61M5/19

CPC classification number: C12N15/113 ,  A61K9/06 ,  A61K31/713 ,  A61K33/243 ,  A61K45/06 ,  A61K47/59 ,  A61K47/61 ,  A61K47/62 ,  A61K47/6923 ,  A61K47/6929 ,  A61K47/6931 ,  A61M5/19 ,  A61P35/04 ,  B82Y5/00 ,  C12N15/111 ,  C12N15/85 ,  C12N2310/141 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2320/32 ,  C12N2740/15043

Abstract: Provided herein are compositions that include a metal nanoparticle functionalized with a miRNA and a targeting molecule. The compositions may be used to prevent or reduce the rate of metastasis of cancer cells. The compositions also may include a drug, such as a chemotherapeutic agent. The compositions also may include a hydrogel in which the metal nanoparticles are dispersed. Methods of miRNA and/or drug delivery and kits also are provided.

公开(公告)号：US20190180139A1

公开(公告)日：2019-06-13

申请号：US16280089

申请日：2019-02-20

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Leor ZACH ,  David GUEZ ,  David LAST ,  Dianne DANIELS ELMAKIAS ,  Yael MARDOR

IPC: G06K9/62 ,  G06T7/00 ,  A61B5/00 ,  A61B5/055

Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.

公开(公告)号：US20190175044A1

公开(公告)日：2019-06-13

申请号：US16324557

申请日：2017-08-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Alex Bronstein ,  Evgeny Tsizin-Goldman

IPC: A61B5/0484 ,  A61B8/00

CPC classification number: A61B5/0484 ,  A61B5/0051 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/6814 ,  A61B5/7235 ,  A61B8/00

Abstract: A diagnostic method includes applying a vibration at a selected frequency to a location within a brain of a living subject (32). Electrical signals resulting from the vibration are measured at multiple positions on a scalp of the subject. The measured electrical signals are processed in order to compute an electrical gain matrix between the location within the brain and the positions on the scalp. Electroencephalogram (EEG) signals are measured at the multiple positions on the scalp. The EEG signals are filtered using the gain matrix in order to identify brain electrical activity originating from the location.

公开(公告)号：US10310287B2

公开(公告)日：2019-06-04

申请号：US15032418

申请日：2014-10-28

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tal Ellenbogen ,  Omri Eisenbach ,  Ori Avayu ,  Ran Ditcovski

IPC: G02B5/30 ,  G02B27/42 ,  G02B1/00 ,  G02B5/00 ,  B82Y20/00

Abstract: An array of optical resonators comprises at least a first type of optical resonators each having a resonant response to an optical field at a first wavelength, and a second type of optical resonators each having a resonant response to an optical field at a second wavelength, being different from the first wavelength. The resonant responses can be selected to reduce chromatic aberrations, or to shape a profile of a light beam, or to selectively switch a near field beam.

公开(公告)号：US20190162520A1

公开(公告)日：2019-05-30

申请号：US16204579

申请日：2018-11-29

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Natan Tzvi SHAKED ,  Nir TURKO

IPC: G01B9/02

Abstract: The present invention relates to a new interferometric module which may be implemented as holographic/interferometric portable optical setups that are based on the interferometry with multiple wavelengths acquired simultaneously, without changing the imaging parameters, such as the magnification and the resolution, and recording the quantitative complex wave front (i.e. amplitude and phase) imaging in several wavelengths simultaneously. This may be used for multiple-wavelength phase unwrapping, for recording higher or optically thicker samples or for spectroscopic holography, without loss of camera frame rate due to wavelength scanning.

公开(公告)号：US10296815B2

公开(公告)日：2019-05-21

申请号：US15749693

申请日：2017-04-20

Applicant: Ramot at Tel Aviv University Ltd.

Inventor： Lior Wolf ,  Assaf Mushinsky

IPC: G06K9/62 ,  G06K9/00 ,  G06K9/46 ,  G06K9/66 ,  G06N3/04 ,  G06N5/04 ,  G06T7/70

Abstract: A convolutional neural network system for detecting at least one object in at least one image. The system includes a plurality of object detectors, corresponding to a predetermined image window size in the at least one image. Each object detector is associated with a respective down-sampling ratio with respect to the at least one image. Each object detector includes a respective convolutional neural network and an object classifier coupled with the convolutional neural network. The respective convolutional neural network includes a plurality of convolution layers. The object classifier classifies objects in the image according to the results from the convolutional neural network. Object detectors associated with the same respective down-sampling ratio define at least one group of object detectors. Object detectors in a group of object detectors being associated with common convolution layers.