-
公开(公告)号：US20060024742A1
公开(公告)日：2006-02-02
申请号：US11240341
申请日：2005-09-30
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acid molecules, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a sdph3.10 and/or sdp3.5 gene product.
-
公开(公告)号：US06897288B1
公开(公告)日：2005-05-24
申请号：US09692401
申请日：2000-10-19
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5154
摘要： The invention provides antigenic peptides derived from MAGE-A12 polypeptides and presented by HLA molecules. Methods for diagnosis and treatment which involve the polypeptides also are provided.
摘要翻译： 本发明提供了衍生自MAGE-A12多肽并由HLA分子呈递的抗原肽。 还提供了涉及多肽的诊断和治疗方法。
-
公开(公告)号：US06710172B1
公开(公告)日：2004-03-23
申请号：US09806769
申请日：2001-07-30
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
IPC分类号： C07H2104
CPC分类号： C07K14/4748
摘要： The present invention relates to nucleic acid molecules encoding antigenic peptides from MAGE molecules that bind to HLA. An example of the nucleic acid molecules of the present invention is a nucleic acid molecule coding for the peptide GVYDGREHTV (SEQ ID NO: 44), which peptide binds to HLA-A2. The nucleic acid molecules and the encoded antigenic peptides are useful for diagnosing and treating various pathological conditions.
摘要翻译： 本发明涉及编码结合HLA的MAGE分子的抗原肽的核酸分子。 本发明的核酸分子的实例是编码肽GVYDGREHTV（SEQ ID NO：44）的核酸分子，该肽与HLA-A2结合。 核酸分子和编码的抗原肽可用于诊断和治疗各种病理状况。
-
公开(公告)号：US06426217B1
公开(公告)日：2002-07-30
申请号：US09697884
申请日：2000-10-27
申请人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号： C12N100
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
-
公开(公告)号：US06369211B1
公开(公告)日：2002-04-09
申请号：US09348933
申请日：1999-07-07
IPC分类号： C07H2102
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes the HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
-
106.发明授权公开(公告)号：US06339149B1
公开(公告)日：2002-01-15
申请号：US09131831
申请日：1998-08-11
IPC分类号： C07H504
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为DAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。
-
公开(公告)号：US06328971B1
公开(公告)日：2001-12-11
申请号：US08292492
申请日：1994-08-18
IPC分类号： A61K3803
CPC分类号： G01N33/5011 , A61K35/17 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/70539 , G01N2333/70539 , G01N2800/52
摘要： This invention relates to MAGE-1 derived nonapeptides. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及MAGE-1衍生的非肽。 该观察的治疗和诊断结果是本发明的主题。
-
公开(公告)号：US06297050B1
公开(公告)日：2001-10-02
申请号：US09322360
申请日：1999-05-28
IPC分类号： C12N508
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为DAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。
-
109.发明授权Method of identifying individuals suffering from a cellular abnormality some of whose abnormal cells present complexes of human leukocyte antigen/tyrosinase derived peptides, and methods for treating said individuals 失效识别患有细胞异常的个体的方法，其一些异常细胞呈现人白细胞抗原/酪氨酸酶衍生肽的复合物，以及用于治疗所述个体的方法公开(公告)号：US06284476B1
公开(公告)日：2001-09-04
申请号：US08540922
申请日：1995-10-11
申请人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wölfel , Bernard Lethé
发明人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wölfel , Bernard Lethé
IPC分类号： G01N3353
CPC分类号： G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/535 , C07K16/243 , C12N9/0071 , C12Y114/18001 , G01N33/505 , Y10S436/813 , Y10S514/885 , Y10S530/828
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的诊断结果是本发明的主题。
-
110.发明授权Method for diagnosing multiple myeloma by determining tumor rejection antigen precursors 失效通过确定肿瘤排斥抗原前体来诊断多发性骨髓瘤的方法公开(公告)号：US06210886B1
公开(公告)日：2001-04-03
申请号：US09183931
申请日：1998-10-30
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods for diagnosing multiple myeloma are disclosed. These methods are based upon the observation that tumor rejection antigen precursors are expressed in multiple myeloma. By assaying bone marrow samples, one can diagnose multiple myeloma, and also monitor the disease's progress. Therapeutic approaches to multiple myeloma are also disclosed.
摘要翻译： 公开了诊断多发性骨髓瘤的方法。 这些方法基于观察到肿瘤排斥抗原前体在多发性骨髓瘤中表达。 通过分析骨髓样本，可以诊断多发性骨髓瘤，并监测疾病的进展。 还公开了多发性骨髓瘤的治疗方法。
-
-
-
-
-
-
-
-
-
搜索结果
161 条记录 (耗时 0.04 秒)
